nhr-64 (Caenorhabditis elegans)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 WBGene00003654 T306178_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in anatomical structure development; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in hypodermis; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha) and HNF4G (hepatocyte nuclear factor 4 gamma). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Hnf4a
M00182_2.00 		Mus musculus
NNRGKYMRNN
NNYKRMCYNN		 PBM
Badis et al.(2009)
Hnf4a_2640 		0.962 0.686
HNF4A
M03357_2.00 		Homo sapiens
RWTGRACTTTGSACYB
VRGTSCAAAGTYCAWY		 SELEX
Jolma et al.(2013)
HNF4A_1 		0.962 0.686
HNF4A
M03358_2.00 		Homo sapiens
RRGGKCAAAGTCCRBN
NVYGGACTTTGMCCYY		 SELEX
Jolma et al.(2013)
HNF4A_2 		0.962 0.686
HNF4A
M03359_2.00 		Homo sapiens
NDTGGACTTTGDACYB
VRGTHCAAAGTCCAHN		 SELEX
Jolma et al.(2013)
HNF4A_3 		0.962 0.686
HNF4A
M03360_2.00 		Homo sapiens
RRGGTCAAAGKTCA
TGAMCTTTGACCYY		 SELEX
Jolma et al.(2013)
HNF4A_4 		0.962 0.686
HNF4A
M03361_2.00 		Homo sapiens
VRGGTCAAAGTCCANN
NNTGGACTTTGACCYB		 SELEX
Jolma et al.(2013)
HNF4A_5 		0.962 0.686
HNF4A
M03362_2.00 		Homo sapiens
RRGTYCAAAGKTCAH
DTGAMCTTTGRACYY		 SELEX
Jolma et al.(2013)
HNF4A_6 		0.962 0.686
Hnf4a
M03426_2.00 		Mus musculus
RRGGTCAAAGTCCANN
NNTGGACTTTGACCYY		 SELEX
Jolma et al.(2013)
Hnf4a_1 		0.962 0.686
HNF4A
M05573_2.00 		Homo sapiens
RRGGTCAAAGGTCRN
NYGACCTTTGACCYY		 SELEX
Yin et al.(2017)
HNF4A_eDBD_HT-SELEX_1 		0.962 0.686
HNF4A
M05574_2.00 		Homo sapiens
RRGGTCAAAGTCCAH
DTGGACTTTGACCYY		 SELEX
Yin et al.(2017)
HNF4A_eDBD_HT-SELEX_2 		0.962 0.686
HNF4A
M05575_2.00 		Homo sapiens
RRGTCCAAAGGTCRN
NYGACCTTTGGACYY		 SELEX
Yin et al.(2017)
HNF4A_eDBD_HT-SELEX_3 		0.962 0.686
HNF4A
M05576_2.00 		Homo sapiens
DTGGACTTTGGACYY
RRGTCCAAAGTCCAH		 SELEX
Yin et al.(2017)
HNF4A_eDBD_HT-SELEX_4 		0.962 0.686
HNF4A
M08219_2.00 		Homo sapiens
VRGDBCAAAGKYCAN
NTGRMCTTTGVHCYB		 ChIP-seq
Contrino et al.(2012)
Mv81 		0.962 0.686
HNF4A
M08220_2.00 		Homo sapiens
AGTCCA
TGGACT		 ChIP-seq
Contrino et al.(2012)
Mv82 		0.962 0.686
HNF4A
M09268_2.00 		Homo sapiens
VRGKNCAAAGTYCA
TGRACTTTGNMCYB		 Misc
Kulakovskiy et al.(2013)
HNF4A_HUMAN.H11MO.0.A 		0.962 0.686
Hnf4a
M09308_2.00 		Mus musculus
NRGKBCAAAGTYCA
TGRACTTTGVMCYN		 Misc
Kulakovskiy et al.(2013)
HNF4A_MOUSE.H11MO.0.A 		0.962 0.686
HNF4A
M09605_2.00 		Homo sapiens
NNVRGDNCAAAGKYCA
TGRMCTTTGNHCYBNN		 Misc
Heinz et al.(2010)
HepG2-HNF4a_GSE25021 		0.962 0.686
HNF4A
M11105_2.00 		Homo sapiens
VRGGNCAAAGKYCRB
VYGRMCTTTGNCCYB		 Transfac
Matys et al.(2006)
V$HNF4_01_B 		0.962 0.686
HNF4A
M11106_2.00 		Homo sapiens
NNNRGDBYAAAGKBCANND
HNNTGVMCTTTRVHCYNNN		 Transfac
Matys et al.(2006)
V$HNF4_01 		0.962 0.686
HNF4A
M11107_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HNF4A_09 		0.962 0.686
HNF4A
M11108_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HNF4A_10 		0.962 0.686
HNF4A
M11109_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HNF4ALPHA_Q6 		0.962 0.686
HNF4A
M11110_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HNF4A_Q3 		0.962 0.686
HNF4A
M11111_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HNF4A_Q6_01 		0.962 0.686
HNF4A
M11112_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HNF4_Q6_01 		0.962 0.686
HNF4A
M11113_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HNF4_Q6_02 		0.962 0.686
HNF4A
M11114_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HNF4_Q6_03 		0.962 0.686
HNF4A
M11115_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HNF4_Q6_04 		0.962 0.686
HNF4A
M05577_2.00 		Homo sapiens
RRGGTCAAAGGTCRN
NYGACCTTTGACCYY		 SELEX
Yin et al.(2017)
HNF4A_eDBD_Methyl-HT-SELEX_1 		0.962 0.686
HNF4A
M05578_2.00 		Homo sapiens
RRGGTCAAAGTCCRN
NYGGACTTTGACCYY		 SELEX
Yin et al.(2017)
HNF4A_eDBD_Methyl-HT-SELEX_2 		0.962 0.686
HNF4A
M05579_2.00 		Homo sapiens
RRGTCCAAAGGTCRN
NYGACCTTTGGACYY		 SELEX
Yin et al.(2017)
HNF4A_eDBD_Methyl-HT-SELEX_3 		0.962 0.686
HNF4A
M05580_2.00 		Homo sapiens
DTGGACTTTGGACYY
RRGTCCAAAGTCCAH		 SELEX
Yin et al.(2017)
HNF4A_eDBD_Methyl-HT-SELEX_4 		0.962 0.686
Hnf4
M03935_2.00 		Drosophila melanogaster
RGGKCAAAGGTCA
TGACCTTTGMCCY		 SELEX
Nitta et al.(2015)
Hnf4_1 		0.961 0.671
Hnf4
M03936_2.00 		Drosophila melanogaster
RGGKCAAAGTYCA
TGRACTTTGMCCY		 SELEX
Nitta et al.(2015)
Hnf4_2 		0.961 0.671
Hnf4
M03937_2.00 		Drosophila melanogaster
RGTVCAAAGKTCR
YGAMCTTTGBACY		 SELEX
Nitta et al.(2015)
Hnf4_3 		0.961 0.671
Hnf4
M03938_2.00 		Drosophila melanogaster
RTGRACTTTGGACY
RGTCCAAAGTYCAY		 SELEX
Nitta et al.(2015)
Hnf4_4 		0.961 0.671
Hnf4
M06428_2.00 		Drosophila melanogaster
DKNKWSSNGGGGTCA
TGACCCCNSSWMNMH		 B1H
Zhu et al.(2011)
Hnf4_SANGER_10_FBgn0004914 		0.961 0.671
Hnf4
M06429_2.00 		Drosophila melanogaster
GGGGTCAH
DTGACCCC		 B1H
Zhu et al.(2011)
Hnf4_SANGER_5_FBgn0004914 		0.961 0.671
HNF4G
M08155_2.00 		Homo sapiens
NVRGDNCAAAGKYCA
TGRMCTTTGNHCYBN		 ChIP-seq
Mathelier et al.(2014)
MA0484.1 		0.960 0.700
HNF4G
M09287_2.00 		Homo sapiens
VRGDNCAAAGKYCA
TGRMCTTTGNHCYB		 Misc
Kulakovskiy et al.(2013)
HNF4G_HUMAN.H11MO.0.B 		0.960 0.700
Hnf4g
M09307_2.00 		Mus musculus
VRGDNCAAAGKYCA
TGRMCTTTGNHCYB		 Misc
Kulakovskiy et al.(2013)
HNF4G_MOUSE.H11MO.0.C 		0.960 0.700
HNF4G
M11155_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HNF4G_01 		0.960 0.700
HNF4G
M11156_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HNF4G_02 		0.960 0.700
nhr-49
M02413_2.00 		Caenorhabditis elegans
NNNNWNHAN
NTDNWNNNN		 PBM
Weirauch et al.(2014)
pTH5891 		0.828 0.529
For this family, TFs with SR scores > 0.745 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
C45E1.1a Nuclear receptor 25 94
C45E1.1b Nuclear receptor 25 50
C45E1.1b Nuclear receptor 48 69

Links

Other Nuclear receptor family TFs
Other Caenorhabditis elegans TFs

Invalid Input OrderBy

393 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action