nhr-86 (Caenorhabditis elegans)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 WBGene00003676 T306199_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in hypodermis and pharynx. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PPARD (peroxisome proliferator activated receptor delta). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
nhr-86
M02415_2.00		 Caenorhabditis elegans
KTGTAGTC
GACTACAM		 PBM
Weirauch et al.(2014)
pTH8598		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
nhr-70
M00695_2.00 		Caenorhabditis elegans
NYTGTAGYYD
HRRCTACARN		 PBM
Narasimhan et al.(2015)
pTH9174 		0.849 0.686
For this family, TFs with SR scores > 0.745 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M02415_2.00 Nuclear receptor 22 91

DNA Binding Domains

Protein ID Domain From To Sequence
Y40B10A.8.1 Nuclear receptor 22 91
Y40B10A.8.2 Nuclear receptor 22 91

Links

Other Nuclear receptor family TFs
Other Caenorhabditis elegans TFs

59 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CRE18529 Caenorhabditis remanei CRE18529 I 0.976
CBG12152 Caenorhabditis briggsae CBG12152 I 0.976
CBG03687 Caenorhabditis briggsae CBG03687 I 0.976
CRE17310 Caenorhabditis remanei CRE17310 I 0.971
nhr-273 Caenorhabditis elegans WBGene00020460 I 0.971
CBN03769 Caenorhabditis brenneri CBN03769 I 0.968
nhr-109 Caenorhabditis elegans WBGene00003699 I 0.968
CBN04619 Caenorhabditis brenneri CBN04619 I 0.954
CJA04414 Caenorhabditis japonica CJA04414 I 0.953
CBN24070 Caenorhabditis brenneri CBN24070 I 0.953
CRE17354 Caenorhabditis remanei CRE17354 I 0.953
CJA07390 Caenorhabditis japonica CJA07390 I 0.953
CBG03688 Caenorhabditis briggsae CBG03688 I 0.932
CRE27659 Caenorhabditis remanei CRE27659 I 0.929
CJA10576 Caenorhabditis japonica CJA10576 I 0.925
CRE17355 Caenorhabditis remanei CRE17355 I 0.924
CBN03440 Caenorhabditis brenneri CBN03440 I 0.923
nhr-16 Caenorhabditis elegans WBGene00003615 I 0.923
CBG16375 Caenorhabditis briggsae CBG16375 I 0.917
nhr-28 Caenorhabditis elegans WBGene00003624 I 0.915
CBN16902 Caenorhabditis brenneri CBN16902 I 0.899
nhr-12 Caenorhabditis elegans WBGene00003611 I 0.895
PPA29361 Pristionchus pacificus PPA29361 I 0.892
CRE27174 Caenorhabditis remanei CRE27174 I 0.885
L889_g9698 Steinernema feltiae L889_g9698 I 0.883
L889_g987 Steinernema feltiae L889_g987 I 0.883
L892_g8140 Steinernema scapterisci L892_g8140 I 0.882
SMUV_0000801801 Syphacia muris SMUV_0000801801 I 0.870
L892_g10708 Steinernema scapterisci L892_g10708 I 0.865
L596_g9106 Steinernema carpocapsae L596_g9106 I 0.865
L893_g2090 Steinernema glaseri L893_g2090 I 0.864
L893_g9517 Steinernema glaseri L893_g9517 I 0.859
L898_g10723 Steinernema monticolum L898_g10723 I 0.858
L893_g4569 Steinernema glaseri L893_g4569 I 0.857
L892_g8145 Steinernema scapterisci L892_g8145 I 0.857
scaffold1235-EXSNAP2012.2 Pristionchus exspectatus scaffold1235-EXSNAP2012.2 I 0.857
scaffold183-EXSNAP2012.18 Pristionchus exspectatus scaffold183-EXSNAP2012.18 I 0.856
PPA08785 Pristionchus pacificus PPA08785 I 0.856
PPA10478 Pristionchus pacificus PPA10478 I 0.855
scaffold260-EXSNAP2012.15 Pristionchus exspectatus scaffold260-EXSNAP2012.15 I 0.855
L596_g27786 Steinernema carpocapsae L596_g27786 I 0.852
SMUV_0000886001 Syphacia muris SMUV_0000886001 I 0.850
nhr-70 Caenorhabditis elegans WBGene00003660 D 0.849
EVEC_0001266201 Enterobius vermicularis EVEC_0001266201 I 0.844
SMUV_0000909301 Syphacia muris SMUV_0000909301 I 0.843
CBG20699 Caenorhabditis briggsae CBG20699 I 0.841
L898_g28806 Steinernema monticolum L898_g28806 I 0.840
L892_g8144 Steinernema scapterisci L892_g8144 I 0.838
CRE07801 Caenorhabditis remanei CRE07801 I 0.829
EVEC_0001095701 Enterobius vermicularis EVEC_0001095701 I 0.824
L889_g10781 Steinernema feltiae L889_g10781 I 0.824
NECAME_01500 Necator americanus NECAME_01500 I 0.822
BXY_0973100 Bursaphelenchus xylophilus BXY_0973100 I 0.820
L889_g17146 Steinernema feltiae L889_g17146 I 0.776
CBG04789 Caenorhabditis briggsae CBG04789 I 0.771
CBN18264 Caenorhabditis brenneri CBN18264 I 0.765
L898_g9580 Steinernema monticolum L898_g9580 I 0.762
L898_g18539 Steinernema monticolum L898_g18539 I 0.759