nhr-123 (Caenorhabditis elegans)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 WBGene00003713 T306235_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in dorsal nerve cord; head neurons; intestine; pharynx; and ventral nerve cord. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
nhr-182
M00701_2.00 		Caenorhabditis elegans
DWBYGTGWCH
DGWCACRVWH		 PBM
Narasimhan et al.(2015)
pTH10779 		0.868 0.529
nhr-182
M00702_2.00 		Caenorhabditis elegans
NNNHRTRNHN
NDNYAYDNNN		 PBM
Narasimhan et al.(2015)
pTH6106 		0.868 0.529
For this family, TFs with SR scores > 0.745 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
M02H5.7 Nuclear receptor 23 92

Links

Other Nuclear receptor family TFs
Other Caenorhabditis elegans TFs

Invalid Input OrderBy

31 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action