nhr-154 (Caenorhabditis elegans)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 WBGene00007547 T306257_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in response to starvation. Predicted to be located in nucleus. Is expressed in alimentary muscle; head neurons; intestine; pharynx; and rectal valve cell. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha) and HNF4G (hepatocyte nuclear factor 4 gamma). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
nhr-154
M00698_2.00		 Caenorhabditis elegans
NRBRYCAHWD
HWDTGRYVYN		 PBM
Narasimhan et al.(2015)
pTH10650		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
CBG23380
M01296_2.00 		Caenorhabditis briggsae
NDBDHHANWN
NWNTDDHVHN		 PBM
Lambert et al.(2019)
pTH11449 		0.990 0.928
For this family, TFs with SR scores > 0.745 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00698_2.00 Nuclear receptor 51 124

DNA Binding Domains

Protein ID Domain From To Sequence
C13C4.2 Nuclear receptor 81 154

Links

Other Nuclear receptor family TFs
Other Caenorhabditis elegans TFs

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70 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action