nhr-180 (Caenorhabditis elegans)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 WBGene00017961 T306341_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in intestine. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
nhr-177
M02419_2.00 		Caenorhabditis elegans
TCGRGANY
RNTCYCGA		 PBM
Weirauch et al.(2014)
pTH9044 		0.779 0.522
For this family, TFs with SR scores > 0.745 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
F31F4.12 Nuclear receptor 14 81

Links

Other Nuclear receptor family TFs
Other Caenorhabditis elegans TFs

19 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CRE27865 Caenorhabditis remanei CRE27865 N 0.967
CRE09175 Caenorhabditis remanei CRE09175 N 0.961
CBN21664 Caenorhabditis brenneri CBN21664 N 0.957
nhr-95 Caenorhabditis elegans WBGene00003685 N 0.954
CBN07208 Caenorhabditis brenneri CBN07208 N 0.946
nhr-228 Caenorhabditis elegans WBGene00020852 N 0.936
CBG10448 Caenorhabditis briggsae CBG10448 N 0.905
CBG01229 Caenorhabditis briggsae CBG01229 N 0.875
CRE09174 Caenorhabditis remanei CRE09174 N 0.867
CRE19030 Caenorhabditis remanei CRE19030 N 0.861
nhr-115 Caenorhabditis elegans WBGene00003705 N 0.857
nhr-125 Caenorhabditis elegans WBGene00003715 I 0.855
nhr-225 Caenorhabditis elegans WBGene00020849 N 0.835
WBGene00020591 Caenorhabditis elegans WBGene00020591 N 0.812
CBG17906 Caenorhabditis briggsae CBG17906 I 0.796
CRE18696 Caenorhabditis remanei CRE18696 N 0.790
CRE09173 Caenorhabditis remanei CRE09173 N 0.783
nhr-177 Caenorhabditis elegans WBGene00017503 D 0.779
nhr-226 Caenorhabditis elegans WBGene00020850 N 0.753