nhr-37 (Caenorhabditis elegans)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 WBGene00018412 T306346_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in neurons and seam cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
nhr-145
M02417_2.00 		Caenorhabditis elegans
NDWVYRNN
NNYRBWHN		 PBM
Weirauch et al.(2014)
pTH6486 		0.844 0.643
For this family, TFs with SR scores > 0.745 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
F44C4.2 Nuclear receptor 5 75

Links

Other Nuclear receptor family TFs
Other Caenorhabditis elegans TFs

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7 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action