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|
ENSBTAP00000048604-D1
(Bos grunniens)
Nuclear receptor
|
TF Information |
|---|
| Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
| PF00105 (zf-C4) |
IPR001628 |
ENSBTAP00000048604-D1 |
T306669_2.00 |
GigaDB (2015-Oct-22) |
| NCBI Gene Info:This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016] |
Directly determined binding motifs |
|---|
| Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR
Score |
DBD
Identity |
| No direct experiments |
|
|
|
|
|
Motifs from related TFs |
|---|
| Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR
Score |
DBD
Identity |
NR2E3
M00373_2.00 |
Homo sapiens |
NRAGATCAMN |
NKTGATCTYN |
PBM
Barrera et al.(2016)
NR2E3_REF
|
0.987
|
1.000
|
Nr2e3
M02708_2.00 |
Mus musculus |
AAGCTTD |
HAAGCTT |
SELEX
Mathelier et al.(2014)
MA0164.1
|
0.987
|
1.000
|
Nr2e3
M09328_2.00 |
Mus musculus |
NAAGTCAAAARKCA |
TGMYTTTTGACTTN |
Misc
Kulakovskiy et al.(2013)
NR2E3_MOUSE.H11MO.0.C
|
0.987
|
1.000
|
NR2E3
M00372_2.00 |
Homo sapiens |
AAAGATCA |
TGATCTTT |
PBM
Barrera et al.(2016)
NR2E3_R77Q
|
0.987
|
0.986
|
NR2E3
M00370_2.00 |
Homo sapiens |
NNNWRABATCANN |
NNTGATVTYWNNN |
PBM
Barrera et al.(2016)
NR2E3_R76Q
|
0.985
|
0.986
|
NR2E3
M00371_2.00 |
Homo sapiens |
NNNHAATWTRTNN |
NNAYAWATTDNNN |
PBM
Barrera et al.(2016)
NR2E3_R76W
|
0.983
|
0.986
|
NR2E3
M00369_2.00 |
Homo sapiens |
NGGGRTCAHN |
NDTGAYCCCN |
PBM
Barrera et al.(2016)
NR2E3_G56R
|
0.980
|
0.986
|
GA30480
M02409_2.00 |
Drosophila pseudoobscura |
RAGATCAM |
KTGATCTY |
PBM
Weirauch et al.(2014)
pTH5877
|
0.977
|
0.843
|
Hr51
M06432_2.00 |
Drosophila melanogaster |
AMRDATCARARGW |
WCYTYTGATHYKT |
B1H
Zhu et al.(2011)
Hr51_SANGER_5_FBgn0034012
|
0.977
|
0.843
|
| For this family, TFs with SR scores > 0.745 will likely have a similar motif |