CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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ENSP00000336528
(
Macaca fascicularis
)
Nuclear receptor
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
PF00105 (zf-C4)
IPR001628
ENSP00000336528
T306699_2.00
GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
NR1I2
M03925_2.00
Homo sapiens
RGKKCRNNVRGKKCR
YGMMCYBNNYGMMCY
SELEX
Nitta et al.(2015)
NR1I2_1
0.988
1.000
NR1I2
M05625_2.00
Homo sapiens
VRGTTCRNNSRGKTCRH
DYGAMCYSNNYGAACYB
SELEX
Yin et al.(2017)
NR1I2_eDBD_HT-SELEX
0.988
1.000
NR1I2
M09283_2.00
Homo sapiens
DDRRBTYMDNNRAGKTCAN
NTGAMCTYNNHKRAVYYHH
Misc
Kulakovskiy et al.(2013)
NR1I2_HUMAN.H11MO.0.C
0.988
1.000
NR1I2
M05626_2.00
Homo sapiens
VRGKKCRNNVRGKKCRN
NYGMMCYBNNYGMMCYB
SELEX
Yin et al.(2017)
NR1I2_eDBD_Methyl-HT-SELEX
0.988
1.000
Nr1i2
M09316_2.00
Mus musculus
DDRRBTYMDNNRAGKTCAN
NTGAMCTYNNHKRAVYYHH
Misc
Kulakovskiy et al.(2013)
NR1I2_MOUSE.H11MO.0.C
0.968
0.971
ENSPMAG00000000180
M02403_2.00
Petromyzon marinus
RGKWCRN
NYGWMCY
PBM
Weirauch et al.(2014)
pTH5509
0.953
0.671
VDR
M03363_2.00
Homo sapiens
GRGTTCAYHGRGTTCA
TGAACYCDRTGAACYC
SELEX
Jolma et al.(2013)
VDR_1
0.935
0.657
Vdr
M03429_2.00
Mus musculus
RRGTTCAYHGRGTTCA
TGAACYCDRTGAACYY
SELEX
Jolma et al.(2013)
Vdr_1
0.935
0.657
VDR
M05877_2.00
Homo sapiens
HRRGTTCA
TGAACYYD
SMiLE-seq
Isakova et al.(2017)
VDR
0.935
0.657
VDR
M09269_2.00
Homo sapiens
NRGGKCANNGRGKKCR
YGMMCYCNNTGMCCYN
Misc
Kulakovskiy et al.(2013)
VDR_HUMAN.H11MO.0.A
0.935
0.657
Vdr
M09315_2.00
Mus musculus
NRGGKCANNGRGKKCR
YGMMCYCNNTGMCCYN
Misc
Kulakovskiy et al.(2013)
VDR_MOUSE.H11MO.0.A
0.935
0.657
VDR
M09606_2.00
Homo sapiens
NRRGGTCANNRRGKKCANNN
NNNTGMMCYYNNTGACCYYN
Misc
Heinz et al.(2010)
GM10855-VDR+vitD_GSE22484
0.935
0.657
VDR
M11116_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$VDR_Q3
0.935
0.657
VDR
M11117_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$VDR_Q6_01
0.935
0.657
VDR
M11118_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$VDR_Q6
0.935
0.657
ENSGALG00000028624
M02398_2.00
Gallus gallus
GRGKTCAH
DTGAMCYC
PBM
Weirauch et al.(2014)
pTH6492
0.890
0.629
NR1I3
M03924_2.00
Homo sapiens
RGKDYRNNNNRGKKYR
YRMMCYNNNNYRHMCY
SELEX
Nitta et al.(2015)
NR1I3_1
0.759
0.586
NR1I3
M05619_2.00
Homo sapiens
WDAGTTCAH
DTGAACTHW
SELEX
Yin et al.(2017)
NR1I3_FL_HT-SELEX
0.759
0.586
NR1I3
M09281_2.00
Homo sapiens
DRGGTCANNNRAGTTYAN
NTRAACTYNNNTGACCYH
Misc
Kulakovskiy et al.(2013)
NR1I3_HUMAN.H11MO.0.C
0.759
0.586
NR1I3
M05620_2.00
Homo sapiens
WDAGTTCRN
NYGAACTHW
SELEX
Yin et al.(2017)
NR1I3_FL_Methyl-HT-SELEX
0.759
0.586
For this family, TFs with SR scores >
0.745
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000336528
Nuclear receptor
78
148
QICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKK
Links
Other
Nuclear receptor
family TFs
Other
Macaca fascicularis
TFs
200 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy