ENSP00000356959 (Macaca fascicularis)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00105 (zf-C4) IPR001628 ENSP00000356959 T306714_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
NR1I3
M03924_2.00
Homo sapiens
RGKDYRNNNNRGKKYR

YRMMCYNNNNYRHMCY
SELEX
Nitta et al.(2015)
NR1I3_1
0.992 0.986
NR1I3
M05619_2.00
Homo sapiens
WDAGTTCAH

DTGAACTHW
SELEX
Yin et al.(2017)
NR1I3_FL_HT-SELEX
0.992 0.986
NR1I3
M09281_2.00
Homo sapiens
DRGGTCANNNRAGTTYAN

NTRAACTYNNNTGACCYH
Misc
Kulakovskiy et al.(2013)
NR1I3_HUMAN.H11MO.0.C
0.992 0.986
NR1I3
M05620_2.00
Homo sapiens
WDAGTTCRN

NYGAACTHW
SELEX
Yin et al.(2017)
NR1I3_FL_Methyl-HT-SELEX
0.992 0.986
Nr1i3
M09302_2.00
Mus musculus
DRGGTCANNNRAGTTYAN

NTRAACTYNNNTGACCYH
Misc
Kulakovskiy et al.(2013)
NR1I3_MOUSE.H11MO.0.C
0.985 0.886
ENSPMAG00000000180
M02403_2.00
Petromyzon marinus
RGKWCRN

NYGWMCY
PBM
Weirauch et al.(2014)
pTH5509
0.826 0.643
VDR
M03363_2.00
Homo sapiens
GRGTTCAYHGRGTTCA

TGAACYCDRTGAACYC
SELEX
Jolma et al.(2013)
VDR_1
0.816 0.629
Vdr
M03429_2.00
Mus musculus
RRGTTCAYHGRGTTCA

TGAACYCDRTGAACYY
SELEX
Jolma et al.(2013)
Vdr_1
0.816 0.629
VDR
M05877_2.00
Homo sapiens
HRRGTTCA

TGAACYYD
SMiLE-seq
Isakova et al.(2017)
VDR
0.816 0.629
VDR
M09269_2.00
Homo sapiens
NRGGKCANNGRGKKCR

YGMMCYCNNTGMCCYN
Misc
Kulakovskiy et al.(2013)
VDR_HUMAN.H11MO.0.A
0.816 0.629
Vdr
M09315_2.00
Mus musculus
NRGGKCANNGRGKKCR

YGMMCYCNNTGMCCYN
Misc
Kulakovskiy et al.(2013)
VDR_MOUSE.H11MO.0.A
0.816 0.629
VDR
M09606_2.00
Homo sapiens
NRRGGTCANNRRGKKCANNN

NNNTGMMCYYNNTGACCYYN
Misc
Heinz et al.(2010)
GM10855-VDR+vitD_GSE22484
0.816 0.629
VDR
M11116_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$VDR_Q3
0.816 0.629
VDR
M11117_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$VDR_Q6_01
0.816 0.629
VDR
M11118_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$VDR_Q6
0.816 0.629
NR1I2
M03925_2.00
Homo sapiens
RGKKCRNNVRGKKCR

YGMMCYBNNYGMMCY
SELEX
Nitta et al.(2015)
NR1I2_1
0.751 0.586
NR1I2
M05625_2.00
Homo sapiens
VRGTTCRNNSRGKTCRH

DYGAMCYSNNYGAACYB
SELEX
Yin et al.(2017)
NR1I2_eDBD_HT-SELEX
0.751 0.586
NR1I2
M09283_2.00
Homo sapiens
DDRRBTYMDNNRAGKTCAN

NTGAMCTYNNHKRAVYYHH
Misc
Kulakovskiy et al.(2013)
NR1I2_HUMAN.H11MO.0.C
0.751 0.586
NR1I2
M05626_2.00
Homo sapiens
VRGKKCRNNVRGKKCRN

NYGMMCYBNNYGMMCYB
SELEX
Yin et al.(2017)
NR1I2_eDBD_Methyl-HT-SELEX
0.751 0.586
For this family, TFs with SR scores > 0.745 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000356959 Nuclear receptor 9 78

Links

Other Nuclear receptor family TFs
Other Macaca fascicularis TFs

139 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
NR1I3 Macaca mulatta ENSMMUG00000018128 I 0.993
ENSCSAG00000002676 Chlorocebus sabaeus ENSCSAG00000002676 I 0.993
ENSPANG00000014194 Papio anubis ENSPANG00000014194 I 0.993
ENSNLEG00000014287 Nomascus leucogenys ENSNLEG00000014287 I 0.992
NR1I3 Homo sapiens ENSG00000143257 D 0.992
NR1I3 Callithrix jacchus ENSCJAG00000004783 I 0.992
NR1I3 Pan troglodytes ENSPTRG00000001582 I 0.992
NR1I3 Gorilla gorilla ENSGGOG00000005724 I 0.991
Nr1i3 Mus musculus ENSMUSG00000005677 D 0.985
Nr1i3 Rattus norvegicus ENSRNOG00000003260 I 0.985
NR1I3 Otolemur garnettii ENSOGAG00000013738 I 0.982
ENSDORG00000001701 Dipodomys ordii ENSDORG00000001701 I 0.980
NR1I3 Procavia capensis ENSPCAG00000013933 I 0.973
NR1I3 Loxodonta africana ENSLAFG00000001180 I 0.973
NR1I3 Canis familiaris ENSCAFG00000012921 I 0.971
ENSOARG00000009965 Ovis aries ENSOARG00000009965 I 0.969
NR1I3 Erinaceus europaeus ENSEEUG00000004981 I 0.967
ENSSHAG00000016687 Sarcophilus harrisii ENSSHAG00000016687 I 0.967
NR1I3 Equus caballus ENSECAG00000020930 I 0.967
NR1I3 Dasypus novemcinctus ENSDNOG00000045179 I 0.967
NR1I3 Oryctolagus cuniculus ENSOCUG00000013537 I 0.967
ENSMEUG00000001987 Macropus eugenii ENSMEUG00000001987 I 0.966
ENSMPUG00000014388 Mustela putorius furo ENSMPUG00000014388 I 0.966
NR1I3 Monodelphis domestica ENSMODG00000005089 I 0.964
NR1I3 Felis catus ENSFCAG00000000497 I 0.964
NR1I3 Ochotona princeps ENSOPRG00000003455 I 0.964
NR1I3 Pteropus vampyrus ENSPVAG00000005540 I 0.961
ENSP00000356959-D1 Bos grunniens ENSP00000356959-D1 I 0.960
NR1I3 Sus scrofa ENSSSCG00000006353 I 0.960
NR1I3 Bos taurus ENSBTAG00000009215 I 0.960
NR1I3 Cavia porcellus ENSCPOG00000015331 I 0.950
NR1I3 Sorex araneus ENSSARG00000002684 I 0.950
ENSSTOG00000003818 Ictidomys tridecemlineatus ENSSTOG00000003818 I 0.948
ENSTSYG00000003712 Tarsius syrichta ENSTSYG00000003712 I 0.944
ENSAMEG00000015383 Ailuropoda melanoleuca ENSAMEG00000015383 I 0.933
Alligator_sinensis_CCG006068.1 Alligator sinensis Alligator_sinensis_CCG006068.1 I 0.879
NR1I2 Otolemur garnettii ENSOGAG00000006017 I 0.853
NR1I3 Tursiops truncatus ENSTTRG00000009227 I 0.851
Ogr03312 Ophisaurus gracilis Ogr03312 I 0.848
nr1i2.L Xenopus laevis XB-GENE-17336519 I 0.846
nr1i2.S Xenopus laevis XB-GENE-865343 I 0.844
NR1I2 Bos taurus ENSBTAG00000019557 I 0.834
NR1I2 Sus scrofa ENSSSCG00000011890 I 0.834
ENSP00000336528-D1 Bos grunniens ENSP00000336528-D1 I 0.834
ENSPFOG00000001655 Poecilia formosa ENSPFOG00000001655 I 0.829
ENSONIG00000009200 Oreochromis niloticus ENSONIG00000009200 I 0.829
ENSAMXG00000019854 Astyanax mexicanus ENSAMXG00000019854 I 0.829
vdrb Danio rerio ENSDARG00000070721 I 0.829
vdralpha Oryzias latipes ENSORLG00000001063 I 0.829
vdr Oryzias latipes ENSORLG00000016402 I 0.829
ENSPSIG00000004437 Pelodiscus sinensis ENSPSIG00000004437 I 0.829
vdra Gasterosteus aculeatus ENSGACG00000004763 I 0.829
vdrb Gasterosteus aculeatus ENSGACG00000007975 I 0.829
vdrb Tetraodon nigroviridis ENSTNIG00000007031 I 0.829
vdrb Takifugu rubripes ENSTRUG00000011576 I 0.829
vdra Takifugu rubripes ENSTRUG00000011907 I 0.829
ENSPFOG00000014233 Poecilia formosa ENSPFOG00000014233 I 0.829
ENSXMAG00000004608 Xiphophorus maculatus ENSXMAG00000004608 I 0.829
ENSGMOG00000019451 Gadus morhua ENSGMOG00000019451 I 0.829
ENSXMAG00000018707 Xiphophorus maculatus ENSXMAG00000018707 I 0.829
Cmyd_10001928 Chelonia mydas Cmyd_10001928 I 0.827
ENSGMOG00000012720 Gadus morhua ENSGMOG00000012720 I 0.827
ENSAMXG00000012991 Astyanax mexicanus ENSAMXG00000012991 I 0.827
ENSPMAG00000000180 Petromyzon marinus ENSPMAG00000000180 D 0.826
ENSONIG00000019378 Oreochromis niloticus ENSONIG00000019378 I 0.824
ENSLOCG00000005194 Lepisosteus oculatus ENSLOCG00000005194 I 0.824
HelroG108893 Helobdella robusta HelroG108893 I 0.821
ENSLACG00000019104 Latimeria chalumnae ENSLACG00000019104 I 0.819
ENSGALG00000026166 Gallus gallus ENSGALG00000026166 I 0.818
Aan_R009572 Calypte anna Aan_R009572 I 0.818
VDR Meleagris gallopavo ENSMGAG00000004846 I 0.818
Gfo_R005027 Geospiza fortis Gfo_R005027 I 0.818
Pvit_07440 Pogona vitticeps Pvit_07440 I 0.818
VDR Anolis carolinensis ENSACAG00000013485 I 0.818
VDR Taeniopygia guttata ENSTGUG00000017093 I 0.818
ENSSTOG00000026741 Ictidomys tridecemlineatus ENSSTOG00000026741 I 0.816
VDR Tupaia belangeri ENSTBEG00000005717 I 0.816
Vdr Mus musculus ENSMUSG00000022479 D 0.816
Vdr Rattus norvegicus ENSRNOG00000054420 I 0.816
VDR Gorilla gorilla ENSGGOG00000016473 I 0.816
VDR Sus scrofa ENSSSCG00000020864 I 0.816
VDR Tursiops truncatus ENSTTRG00000012578 I 0.816
VDR Dasypus novemcinctus ENSDNOG00000039161 I 0.816
ENSCHOG00000008514 Choloepus hoffmanni ENSCHOG00000008514 I 0.816
Myotis_brandtii_VDR_10022134 Myotis brandtii Myotis_brandtii_VDR_10022134 I 0.816
ENSCSAG00000006576 Chlorocebus sabaeus ENSCSAG00000006576 I 0.816
ENSCPOG00000006025 Cavia porcellus ENSCPOG00000006025 I 0.816
ENSP00000229022-D1 Bos grunniens ENSP00000229022-D1 I 0.816
ENSMMUP00000008847 Macaca fascicularis ENSMMUP00000008847 I 0.816
VDR Felis catus ENSFCAG00000024594 I 0.816
VDR Pteropus vampyrus ENSPVAG00000011085 I 0.816
VDR Erinaceus europaeus ENSEEUG00000011116 I 0.816
VDR Equus caballus ENSECAG00000015822 I 0.816
VDR Homo sapiens ENSG00000111424 D 0.816
VDR Canis familiaris ENSCAFG00000009103 I 0.816
VDR Bos taurus ENSBTAG00000016414 I 0.816
VDR Macaca mulatta ENSMMUG00000006727 I 0.816
VDR Myotis lucifugus ENSMLUG00000000912 I 0.816
VDR Microcebus murinus ENSMICG00000009017 I 0.816
VDR Otolemur garnettii ENSOGAG00000005480 I 0.816
VDR Oryctolagus cuniculus ENSOCUG00000027507 I 0.816
ENSMPUG00000000419 Mustela putorius furo ENSMPUG00000000419 I 0.816
ENSNLEG00000017900 Nomascus leucogenys ENSNLEG00000017900 I 0.816
ENSOARG00000019372 Ovis aries ENSOARG00000019372 I 0.816
ENSMODG00000028774 Monodelphis domestica ENSMODG00000028774 I 0.816
ENSPANG00000011327 Papio anubis ENSPANG00000011327 I 0.816
VDR Callithrix jacchus ENSCJAG00000015018 I 0.816
ENSPPYG00000004448 Pongo abelii ENSPPYG00000004448 I 0.816
VDR Loxodonta africana ENSLAFG00000006418 I 0.816
ENSMEUG00000014791 Macropus eugenii ENSMEUG00000014791 I 0.816
ENSAMEG00000013706 Ailuropoda melanoleuca ENSAMEG00000013706 I 0.816
Pvit_09406 Pogona vitticeps Pvit_09406 I 0.811
Pvit_09404 Pogona vitticeps Pvit_09404 I 0.811
ENSPSIG00000018108 Pelodiscus sinensis ENSPSIG00000018108 I 0.805
Afo_R013462 Aptenodytes forsteri Afo_R013462 I 0.805
Cmyd_10006875 Chelonia mydas Cmyd_10006875 I 0.805
NR1I2 Canis familiaris ENSCAFG00000011094 I 0.805
ENSPMAG00000003695 Petromyzon marinus ENSPMAG00000003695 I 0.795
ENSSHAG00000004437 Sarcophilus harrisii ENSSHAG00000004437 I 0.787
vdr Xenopus tropicalis XB-GENE-486505 I 0.786
vdr.S Xenopus laevis XB-GENE-864847 I 0.786
ENSACAG00000001535 Anolis carolinensis ENSACAG00000001535 I 0.780
ENSLACG00000010334 Latimeria chalumnae ENSLACG00000010334 I 0.778
NEMVEDRAFT_v1g165424 Nematostella vectensis NEMVEDRAFT_v1g165424 I 0.776
NR1I2 Myotis lucifugus ENSMLUG00000002877 I 0.769
Myotis_brandtii_NR1I2_10031787 Myotis brandtii Myotis_brandtii_NR1I2_10031787 I 0.769
ENSMEUG00000000113 Macropus eugenii ENSMEUG00000000113 I 0.760
NR1I2 Callithrix jacchus ENSCJAG00000008854 I 0.751
ENSNLEG00000005060 Nomascus leucogenys ENSNLEG00000005060 I 0.751
ENSTSYG00000010757 Tarsius syrichta ENSTSYG00000010757 I 0.751
ENSAMEG00000007006 Ailuropoda melanoleuca ENSAMEG00000007006 I 0.751
NR1I2 Felis catus ENSFCAG00000006092 I 0.751
NR1I2 Equus caballus ENSECAG00000008728 I 0.751
NR1I2 Macaca mulatta ENSMMUG00000001976 I 0.751
NR1I2 Homo sapiens ENSG00000144852 D 0.751
NR1I2 Echinops telfairi ENSETEG00000018117 I 0.751
ENSP00000336528 Macaca fascicularis ENSP00000336528 I 0.751
NR1I2 Gorilla gorilla ENSGGOG00000007361 I 0.751
NR1I2 Pan troglodytes ENSPTRG00000015263 I 0.751