TF Information

HHAL004926-PA *(Halyomorpha halys)* Nuclear receptor
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source
PF00105 (zf-C4)	IPR001628	HHAL004926-PA	T307105_2.00	Misc (2018-Jan-19)
NCBI Gene Info: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
No direct experiments
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
EcR M06414_2.00	Drosophila melanogaster	RAGGTCAW	WTGACCTY	B1H Zhu et al.(2011) EcR_SANGER_5_FBgn0000546	0.920	0.862
nr1h5.S M11194_2.00	Xenopus laevis	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$FXRIR1_Q6	0.863	0.845
NR1H4 M00368_2.00	Homo sapiens	NVRGGTCANN	NNTGACCYBN	PBM Barrera et al.(2016) NR1H4_REF	0.852	0.810
NR1H4 M05876_2.00	Homo sapiens	DRGKTCAHHKD	HMDDTGAMCYH	SMiLE-seq Isakova et al.(2017) NR1H4	0.852	0.810
NR1H4 M08152_2.00	Homo sapiens	NNGGTCATTNN	NNAATGACCNN	ChIP-seq Mathelier et al.(2014) MA1110.1	0.852	0.810
NR1H4 M09263_2.00	Homo sapiens	CCBVNVGGYCRBTGMCCYB	VRGGKCAVYGRCCBNBVGG	Misc Kulakovskiy et al.(2013) NR1H4_HUMAN.H11MO.0.B	0.852	0.810
Nr1h4 M09332_2.00	Mus musculus	CCBVNVGGYCRBTGMCCYB	VRGGKCAVYGRCCBNBVGG	Misc Kulakovskiy et al.(2013) NR1H4_MOUSE.H11MO.0.A	0.852	0.810
Nr1h4 M09618_2.00	Mus musculus	NRGGBCANTGVCCY	RGGBCANTGVCCYN	Misc Heinz et al.(2010) Liver-FXR_Chong_et_al.	0.852	0.810
NR1H4 M11086_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$FXR_Q2	0.852	0.810
NR1H4 M11087_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$FXR_Q3	0.852	0.810
NR1H4 M11088_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$FXR_Q5	0.852	0.810
NR1H4 M11089_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$FXRRXR_Q5	0.852	0.810
NR1H4 M00367_2.00	Homo sapiens	NNNTWTTATDHNN	NNDHATAAWANNN	PBM Barrera et al.(2016) NR1H4_C144R	0.852	0.793
NR1H3 M09264_2.00	Homo sapiens	NHRRGGBHABHNNRGGNCA	TGNCCYNNDVTDVCCYYDN	Misc Kulakovskiy et al.(2013) NR1H3_HUMAN.H11MO.0.B	0.793	0.655
Nr1h3 M09301_2.00	Mus musculus	VDGDNCARAGKBCAN	NTGVMCTYTGNHCHB	Misc Kulakovskiy et al.(2013) NR1H3_MOUSE.H11MO.0.A	0.793	0.655
For this family, TFs with SR scores > 0.745* will likely have a similar motif*