HHAL008774-PA (Halyomorpha halys)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00105 (zf-C4) IPR001628 HHAL008774-PA T307109_2.00 Misc (2018-Jan-19)
NCBI Gene Info:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Hr38
M03939_2.00
Drosophila melanogaster
NAAAGGTCA

TGACCTTTN
SELEX
Nitta et al.(2015)
Hr38_1
0.992 0.957
Nr4a2
M00818_2.00
Mus musculus
AAAGGTCA

TGACCTTT
PBM
Weirauch et al.(2013)
pTH3467
0.982 0.886
NR4A2
M03383_2.00
Homo sapiens
AGGTCAHNNNDTGACCT

AGGTCAHNNNDTGACCT
SELEX
Jolma et al.(2013)
NR4A2_1
0.982 0.886
NR4A2
M03384_2.00
Homo sapiens
TGACCTTTAAAGGTCA

TGACCTTTAAAGGTCA
SELEX
Jolma et al.(2013)
NR4A2_2
0.982 0.886
NR4A2
M03385_2.00
Homo sapiens
NBTAAAGGTCA

TGACCTTTAVN
SELEX
Jolma et al.(2013)
NR4A2_3
0.982 0.886
NR4A2
M05639_2.00
Homo sapiens
NWAAKGTCAN

NTGACMTTWN
SELEX
Yin et al.(2017)
NR4A2_eDBD_HT-SELEX
0.982 0.886
NR4A2
M05881_2.00
Homo sapiens
NAAAKGTYA

TRACMTTTN
SMiLE-seq
Isakova et al.(2017)
NR4A2
0.982 0.886
NR4A2
M09286_2.00
Homo sapiens
RAAGGTCAV

BTGACCTTY
Misc
Kulakovskiy et al.(2013)
NR4A2_HUMAN.H11MO.0.C
0.982 0.886
Nr4a2
M09323_2.00
Mus musculus
RAAGGTCAV

BTGACCTTY
Misc
Kulakovskiy et al.(2013)
NR4A2_MOUSE.H11MO.0.C
0.982 0.886
NR4A2
M11151_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NURR1_Q3_01
0.982 0.886
NR4A2
M11152_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NURR1_Q3
0.982 0.886
NR4A2
M08461_2.00
Homo sapiens
RAGGTCAM

KTGACCTY
COMPILED
Mathelier et al.(2014)
MA0160.1
0.982 0.886
NR4A2
M05640_2.00
Homo sapiens
NAAAGGTCRN

NYGACCTTTN
SELEX
Yin et al.(2017)
NR4A2_eDBD_Methyl-HT-SELEX
0.982 0.886
NR4A1
M05601_2.00
Homo sapiens
NAAAGGTCAN

NTGACCTTTN
SELEX
Yin et al.(2017)
NR4A1_eDBD_HT-SELEX_1
0.976 0.857
NR4A1
M05602_2.00
Homo sapiens
NAAAGGTCAN

NTGACCTTTN
SELEX
Yin et al.(2017)
NR4A1_eDBD_HT-SELEX_2
0.976 0.857
NR4A1
M08153_2.00
Homo sapiens
NAAAGGTCAN

NTGACCTTTN
ChIP-seq
Mathelier et al.(2014)
MA1112.1
0.976 0.857
NR4A1
M09274_2.00
Homo sapiens
AAAKGBCAN

NTGVCMTTT
Misc
Kulakovskiy et al.(2013)
NR4A1_HUMAN.H11MO.0.A
0.976 0.857
Nr4a1
M09317_2.00
Mus musculus
NRAADGKCA

TGMCHTTYN
Misc
Kulakovskiy et al.(2013)
NR4A1_MOUSE.H11MO.0.B
0.976 0.857
NR4A1
M09608_2.00
Homo sapiens
NNDNAAAGGTCA

TGACCTTTNHNN
Misc
Heinz et al.(2010)
K562-NR4A1_GSE31363
0.976 0.857
NR4A1
M11132_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NUR77_Q5_01
0.976 0.857
NR4A1
M11133_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NUR77_Q5_02
0.976 0.857
NR4A1
M11134_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NUR77_Q5
0.976 0.857
NR4A1
M05603_2.00
Homo sapiens
NAAAGGTCRN

NYGACCTTTN
SELEX
Yin et al.(2017)
NR4A1_eDBD_Methyl-HT-SELEX_1
0.976 0.857
NR4A1
M05604_2.00
Homo sapiens
NAAAGGTCRN

NYGACCTTTN
SELEX
Yin et al.(2017)
NR4A1_eDBD_Methyl-HT-SELEX_2
0.976 0.857
nhr-6
M01298_2.00
Caenorhabditis elegans
AAAKGTCA

TGACMTTT
PBM
Lambert et al.(2019)
pTH9944
0.943 0.729
Hr4
M06435_2.00
Drosophila melanogaster
AAGGTCA

TGACCTT
B1H
Zhu et al.(2011)
Hr4_SANGER_5_FBgn0023546
0.834 0.557
Q95WG3_ACRMI
M02424_2.00
Acropora millepora
NRAGGTCAN

NTGACCTYN
PBM
Weirauch et al.(2014)
pTH6144
0.803 0.600
Rxrb
M02402_2.00
Mus musculus
VRGGTCAH

DTGACCYB
PBM
Weirauch et al.(2014)
pTH2861
0.802 0.614
RXRB
M03415_2.00
Homo sapiens
RRGGTCAAAGGTCA

TGACCTTTGACCYY
SELEX
Jolma et al.(2013)
RXRB_1
0.802 0.614
Rxrb
M03435_2.00
Mus musculus
GRGGTCAAAGGTCA

TGACCTTTGACCYC
SELEX
Jolma et al.(2013)
Rxrb_1
0.802 0.614
RXRB
M05681_2.00
Homo sapiens
RRGGTCAAAGGTCAN

NTGACCTTTGACCYY
SELEX
Yin et al.(2017)
RXRB_eDBD_HT-SELEX_1
0.802 0.614
RXRB
M05682_2.00
Homo sapiens
RRGGTCAYGACCYY

RRGGTCRTGACCYY
SELEX
Yin et al.(2017)
RXRB_eDBD_HT-SELEX_2
0.802 0.614
RXRB
M09297_2.00
Homo sapiens
DSAGGTCASD

HSTGACCTSH
Misc
Kulakovskiy et al.(2013)
RXRB_HUMAN.H11MO.0.C
0.802 0.614
Rxrb
M09330_2.00
Mus musculus
DSAGGTCASD

HSTGACCTSH
Misc
Kulakovskiy et al.(2013)
RXRB_MOUSE.H11MO.0.C
0.802 0.614
RXRB
M05683_2.00
Homo sapiens
RRGGTCAAAGGTCRN

NYGACCTTTGACCYY
SELEX
Yin et al.(2017)
RXRB_eDBD_Methyl-HT-SELEX_1
0.802 0.614
RXRB
M05684_2.00
Homo sapiens
RRGGTCRYGACCYY

RRGGTCRYGACCYY
SELEX
Yin et al.(2017)
RXRB_eDBD_Methyl-HT-SELEX_2
0.802 0.614
usp
M03934_2.00
Drosophila melanogaster
ARRGGTCAAAGGTCA

TGACCTTTGACCYYT
SELEX
Nitta et al.(2015)
usp_1
0.801 0.600
usp
M06426_2.00
Drosophila melanogaster
HRRGGTCAH

DTGACCYYD
B1H
Zhu et al.(2011)
usp_SANGER_5_FBgn0003964
0.801 0.600
usp
M02709_2.00
Drosophila melanogaster
GGGGTCACSN

NSGTGACCCC
SELEX
Mathelier et al.(2014)
MA0016.1
0.801 0.600
usp
M09689_2.00
Drosophila melanogaster
KRGGTCACG

CGTGACCYM
Misc
Kulakovskiy et al.(2009)
usp
0.801 0.600
usp
M11191_2.00
Drosophila melanogaster
GRGGTCAYS

SRTGACCYC
Transfac
Matys et al.(2006)
I$CF1_01
0.801 0.600
usp
M11192_2.00
Drosophila melanogaster
GGGGTCAYS

SRTGACCCC
Transfac
Matys et al.(2006)
I$CF1_02
0.801 0.600
Rxra
M00181_2.00
Mus musculus
NRRGGTCANN

NNTGACCYYN
PBM
Badis et al.(2009)
Rxra_1035
0.798 0.600
RXRA
M03408_2.00
Homo sapiens
RRGGTCAAAGGTCA

TGACCTTTGACCYY
SELEX
Jolma et al.(2013)
RXRA_1
0.798 0.600
RXRA
M03409_2.00
Homo sapiens
RRGGTCATGACCYY

RRGGTCATGACCYY
SELEX
Jolma et al.(2013)
RXRA_2
0.798 0.600
RXRA
M03410_2.00
Homo sapiens
RRGGTCAAAGGTCA

TGACCTTTGACCYY
SELEX
Jolma et al.(2013)
RXRA_3
0.798 0.600
RXRA
M03411_2.00
Homo sapiens
RRGGTCATGACCYY

RRGGTCATGACCYY
SELEX
Jolma et al.(2013)
RXRA_4
0.798 0.600
Rxra
M03421_2.00
Mus musculus
RRGGTCAAAGGTCA

TGACCTTTGACCYY
SELEX
Jolma et al.(2013)
Rxra_1
0.798 0.600
Rxra
M03422_2.00
Mus musculus
RGGTCATGACCY

RGGTCATGACCY
SELEX
Jolma et al.(2013)
Rxra_2
0.798 0.600
RXRA
M05671_2.00
Homo sapiens
RRGGTCAAAGGTCAN

NTGACCTTTGACCYY
SELEX
Yin et al.(2017)
RXRA_eDBD_HT-SELEX
0.798 0.600
RXRA
M05882_2.00
Homo sapiens
VRGKTBAAAGGTYRH

DYRACCTTTVAMCYB
SMiLE-seq
Isakova et al.(2017)
RXRa
0.798 0.600
RXRA
M07993_2.00
Homo sapiens
NRRGGTCA

TGACCYYN
ChIP-seq
Gerstein et al.(2012)
H1-hESC_RXRA_HudsonAlpha
0.798 0.600
RXRA
M07994_2.00
Homo sapiens
DDNNMRRGGTCANDN

NHNTGACCYYKNNHH
ChIP-seq
Gerstein et al.(2012)
HepG2_RXRA_HudsonAlpha
0.798 0.600
RXRA
M09294_2.00
Homo sapiens
VDDDNDNNVRRRGGKCAVDV

BHBTGMCCYYYBNNHNHHHB
Misc
Kulakovskiy et al.(2013)
RXRA_HUMAN.H11MO.0.A
0.798 0.600
Rxra
M09306_2.00
Mus musculus
DDVNNNNNRAGKTCAAGGYCA

TGRCCTTGAMCTYNNNNNBHH
Misc
Kulakovskiy et al.(2013)
RXRA_MOUSE.H11MO.0.A
0.798 0.600
RXRA
M11182_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$RXRA_07
0.798 0.600
RXRA
M05672_2.00
Homo sapiens
RRGGTCAAAGGTCAH

DTGACCTTTGACCYY
SELEX
Yin et al.(2017)
RXRA_eDBD_Methyl-HT-SELEX
0.798 0.600
Rxrg
M02400_2.00
Mus musculus
VRGGTCAN

NTGACCYB
PBM
Weirauch et al.(2014)
pTH2880
0.792 0.586
RXRG
M03375_2.00
Homo sapiens
RRGGTCAAAGGTCA

TGACCTTTGACCYY
SELEX
Jolma et al.(2013)
RXRG_1
0.792 0.586
RXRG
M03376_2.00
Homo sapiens
RRGGTCATGACCYY

RRGGTCATGACCYY
SELEX
Jolma et al.(2013)
RXRG_2
0.792 0.586
RXRG
M03377_2.00
Homo sapiens
GRGGTCAAAGGTCA

TGACCTTTGACCYC
SELEX
Jolma et al.(2013)
RXRG_3
0.792 0.586
RXRG
M03378_2.00
Homo sapiens
NRGGTCATGACCYC

GRGGTCATGACCYN
SELEX
Jolma et al.(2013)
RXRG_4
0.792 0.586
RXRG
M02746_2.00
Homo sapiens
GGTCAAAGGTCA

TGACCTTTGACC
SELEX
Jolma et al.(2010)
RXRG_dimer
0.792 0.586
RXRG
M05615_2.00
Homo sapiens
VRGGTCAAAGGTCAN

NTGACCTTTGACCYB
SELEX
Yin et al.(2017)
RXRG_FL_HT-SELEX_1
0.792 0.586
RXRG
M05616_2.00
Homo sapiens
RRGGTCAYGACCYY

RRGGTCRTGACCYY
SELEX
Yin et al.(2017)
RXRG_FL_HT-SELEX_2
0.792 0.586
RXRG
M05879_2.00
Homo sapiens
RGGTBAARGGTBRND

HNYVACCYTTVACCY
SMiLE-seq
Isakova et al.(2017)
RXRg
0.792 0.586
RXRG
M09280_2.00
Homo sapiens
NGTCAAAGGTCAH

DTGACCTTTGACN
Misc
Kulakovskiy et al.(2013)
RXRG_HUMAN.H11MO.0.B
0.792 0.586
Rxrg
M09305_2.00
Mus musculus
VDDVDNSVNRAGKTCAAGGYCA

TGRCCTTGAMCTYNBSNHBHHB
Misc
Kulakovskiy et al.(2013)
RXRG_MOUSE.H11MO.0.B
0.792 0.586
RXRG
M05617_2.00
Homo sapiens
DRGGTBAARGGTBRN

NYVACCYTTVACCYH
SELEX
Yin et al.(2017)
RXRG_FL_Methyl-HT-SELEX_1
0.792 0.586
RXRG
M05618_2.00
Homo sapiens
VRGGTCAYGACCYB

VRGGTCRTGACCYB
SELEX
Yin et al.(2017)
RXRG_FL_Methyl-HT-SELEX_2
0.792 0.586
Nr2f6
M00811_2.00
Mus musculus
NRRGGTCANN

NNTGACCYYN
PBM
Weirauch et al.(2013)
pTH2193
0.785 0.514
Nr2f6
M03419_2.00
Mus musculus
RAGGTCAADAGGTCA

TGACCTHTTGACCTY
SELEX
Jolma et al.(2013)
Nr2f6_1
0.785 0.514
Nr2f6
M03420_2.00
Mus musculus
RRGGTCAAAGGTCA

TGACCTTTGACCYY
SELEX
Jolma et al.(2013)
Nr2f6_2
0.785 0.514
For this family, TFs with SR scores > 0.745 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
HHAL008774-PA Nuclear receptor 47 116

Links

Other Nuclear receptor family TFs
Other Halyomorpha halys TFs

758 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ZBTB7C Homo sapiens ENSG00000184828 D 0.000
ZBTB7C Pan troglodytes ENSPTRG00000010006 I 0.000
ENSPSIG00000006571 Pelodiscus sinensis ENSPSIG00000006571 I 0.000
ENSPPYG00000009145 Pongo abelii ENSPPYG00000009145 I 0.000
ENSPFOG00000009365 Poecilia formosa ENSPFOG00000009365 I 0.000
ENSPANG00000016942 Papio anubis ENSPANG00000016942 I 0.000
zbtb7c Oryzias latipes ENSORLG00000005778 I 0.000
ZBTB7C Ochotona princeps ENSOPRG00000006181 I 0.000
ENSONIG00000007754 Oreochromis niloticus ENSONIG00000007754 I 0.000
ZBTB7C Otolemur garnettii ENSOGAG00000000444 I 0.000
ZBTB7C Oryctolagus cuniculus ENSOCUG00000022348 I 0.000
ENSOARG00000003681 Ovis aries ENSOARG00000003681 I 0.000
Zbtb7c Rattus norvegicus ENSRNOG00000047924 I 0.000
XP_002936550 Xenopus tropicalis XP_002936550 I 0.000
ZBTB7C Sorex araneus ENSSARG00000009541 I 0.000
Pvit_17431 Pogona vitticeps Pvit_17431 I 0.000
Myotis_brandtii_ZBTB7C_10020629 Myotis brandtii Myotis_brandtii_ZBTB7C_10020629 I 0.000
Cmyd_10012256 Chelonia mydas Cmyd_10012256 I 0.000
Brh_R000624 Buceros rhinoceros Brh_R000624 I 0.000
Alligator_sinensis_CCG005049.1 Alligator sinensis Alligator_sinensis_CCG005049.1 I 0.000
ZBTB7C Tursiops truncatus ENSTTRG00000011636 I 0.000
zbtb7c Takifugu rubripes ENSTRUG00000010287 I 0.000
zbtb7c Tetraodon nigroviridis ENSTNIG00000018762 I 0.000
ZBTB7C Taeniopygia guttata ENSTGUG00000000028 I 0.000
ENSSTOG00000011681 Ictidomys tridecemlineatus ENSSTOG00000011681 I 0.000
ENSSHAG00000013931 Sarcophilus harrisii ENSSHAG00000013931 I 0.000
ENSNLEG00000011492 Nomascus leucogenys ENSNLEG00000011492 I 0.000
Zbtb7c Mus musculus ENSMUSG00000044646 I 0.000
ENSFALG00000008940 Ficedula albicollis ENSFALG00000008940 I 0.000
ZBTB7C Equus caballus ENSECAG00000020456 I 0.000
Zbtb7c Dipodomys ordii ENSDORG00000002188 I 0.000
ZBTB7C Dasypus novemcinctus ENSDNOG00000045505 I 0.000
zbtb7c Danio rerio ENSDARG00000100985 I 0.000
ENSCSAG00000018018 Chlorocebus sabaeus ENSCSAG00000018018 I 0.000
ENSCPOG00000008882 Cavia porcellus ENSCPOG00000008882 I 0.000
ZBTB7C Callithrix jacchus ENSCJAG00000004704 I 0.000
ENSCAFG00000019080 Canis familiaris ENSCAFG00000019080 I 0.000
ZBTB7C Bos taurus ENSBTAG00000013306 I 0.000
ENSAMXG00000015988 Astyanax mexicanus ENSAMXG00000015988 I 0.000
ZBTB7C Felis catus ENSFCAG00000030658 I 0.000
zbtb7c Gasterosteus aculeatus ENSGACG00000016516 I 0.000
ENSMPUG00000000848 Mustela putorius furo ENSMPUG00000000848 I 0.000
ZBTB7C Monodelphis domestica ENSMODG00000003412 I 0.000
ENSMMUG00000015704 Macaca mulatta ENSMMUG00000015704 I 0.000
ZBTB7C Myotis lucifugus ENSMLUG00000030000 I 0.000
ENSMICG00000017920 Microcebus murinus ENSMICG00000017920 I 0.000
ENSLOCG00000011712 Lepisosteus oculatus ENSLOCG00000011712 I 0.000
ZBTB7C Loxodonta africana ENSLAFG00000003436 I 0.000
ENSLACG00000005229 Latimeria chalumnae ENSLACG00000005229 I 0.000
ENSGMOG00000003470 Gadus morhua ENSGMOG00000003470 I 0.000
ZBTB7C Gorilla gorilla ENSGGOG00000008438 I 0.000
ENSGALG00000014696 Gallus gallus ENSGALG00000014696 I 0.000
ZBTB7C Anolis carolinensis ENSACAG00000018007 I 0.000