CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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TP63
(
Homo sapiens
)
p53
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00870 (P53)
IPR011615
ENSG00000073282
T311038_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
TP63
M03437_2.00
Homo sapiens
DACATGTYVYRACATGTY
RACATGTYRBRACATGTH
SELEX
Jolma et al.(2013)
TP63_1
(Direct)
(Direct)
TP63
M09335_2.00
Homo sapiens
DRCAWGYHCHRRCHTGYHN
NDRCADGYYDGDRCWTGYH
Misc
Kulakovskiy et al.(2013)
P63_HUMAN.H11MO.0.A
(Direct)
(Direct)
TP63
M11195_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P63_01
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Trp63
M09338_2.00
Mus musculus
DRCAWGYHCHRRCHTGYHN
NDRCADGYYDGDRCWTGYH
Misc
Kulakovskiy et al.(2013)
P63_MOUSE.H11MO.0.B
1.000
1.000
Trp73
M03438_2.00
Mus musculus
DRCAWGTYNNRACAYGYH
DRCRTGTYNNRACWTGYH
SELEX
Jolma et al.(2013)
Tp73_1
0.857
0.857
TP73
M08035_2.00
Homo sapiens
RCADGYHSDGRCWDG
CHWGYCHSDRCHTGY
ChIP-seq
Chen et al.(2011)
GSE15704_TP73_rapamycin
0.857
0.857
TP73
M08036_2.00
Homo sapiens
DRRCAWGYHCWGRCWTGYH
DRCAWGYCWGDRCWTGYYH
ChIP-seq
Chen et al.(2011)
GSE15704_TP73_vehicle
0.857
0.857
TP73
M08037_2.00
Homo sapiens
RCMDGYBCHNDCHKG
CMDGHNDGVRCHKGY
ChIP-seq
Chen et al.(2011)
GSE18650_TP73
0.857
0.857
TP73
M09336_2.00
Homo sapiens
NDDCHWGYYCMRRCHTGYH
DRCADGYYKGRRCWDGHHN
Misc
Kulakovskiy et al.(2013)
P73_HUMAN.H11MO.0.A
0.857
0.857
Trp73
M09339_2.00
Mus musculus
NDDCHWGYYCMRRCHTGYH
DRCADGYYKGRRCWDGHHN
Misc
Kulakovskiy et al.(2013)
P73_MOUSE.H11MO.0.B
0.857
0.857
TP73
M11196_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P73_Q6
0.857
0.857
For this family, TFs with SR scores >
0.700
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000264731
p53
163
359
PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSP00000317510
p53
163
359
PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSP00000346614
p53
69
265
PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSP00000376253
p53
163
359
PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSP00000376254
p53
69
265
PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSP00000376256
p53
69
265
PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSP00000387839
p53
3
180
YLENNAQTQFSEYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSP00000389485
p53
69
265
PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSP00000392488
p53
69
265
PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSP00000394337
p53
163
359
PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSP00000401661
p53
69
141
PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTSLALSPRLECNGMISAHCNLHLLGSSGSPFSASQVGGITGTR
ENSP00000401661
p53
148
183
FGTTSAHCNLRLLDSSDSPFSASQYSTELKKLYCQI
ENSP00000407144
p53
163
359
PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
Links
Other
p53
family TFs
Other
Homo sapiens
TFs
125 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy