TP63 (Homo sapiens)
p53

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00870 (P53) IPR011615 ENSG00000073282 T311038_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
TP63
M03437_2.00
Homo sapiens
DACATGTYVYRACATGTY

RACATGTYRBRACATGTH
SELEX
Jolma et al.(2013)
TP63_1
(Direct) (Direct)
TP63
M09335_2.00
Homo sapiens
DRCAWGYHCHRRCHTGYHN

NDRCADGYYDGDRCWTGYH
Misc
Kulakovskiy et al.(2013)
P63_HUMAN.H11MO.0.A
(Direct) (Direct)
TP63
M11195_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P63_01
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Trp63
M09338_2.00
Mus musculus
DRCAWGYHCHRRCHTGYHN

NDRCADGYYDGDRCWTGYH
Misc
Kulakovskiy et al.(2013)
P63_MOUSE.H11MO.0.B
1.000 1.000
Trp73
M03438_2.00
Mus musculus
DRCAWGTYNNRACAYGYH

DRCRTGTYNNRACWTGYH
SELEX
Jolma et al.(2013)
Tp73_1
0.857 0.857
TP73
M08035_2.00
Homo sapiens
RCADGYHSDGRCWDG

CHWGYCHSDRCHTGY
ChIP-seq
Chen et al.(2011)
GSE15704_TP73_rapamycin
0.857 0.857
TP73
M08036_2.00
Homo sapiens
DRRCAWGYHCWGRCWTGYH

DRCAWGYCWGDRCWTGYYH
ChIP-seq
Chen et al.(2011)
GSE15704_TP73_vehicle
0.857 0.857
TP73
M08037_2.00
Homo sapiens
RCMDGYBCHNDCHKG

CMDGHNDGVRCHKGY
ChIP-seq
Chen et al.(2011)
GSE18650_TP73
0.857 0.857
TP73
M09336_2.00
Homo sapiens
NDDCHWGYYCMRRCHTGYH

DRCADGYYKGRRCWDGHHN
Misc
Kulakovskiy et al.(2013)
P73_HUMAN.H11MO.0.A
0.857 0.857
Trp73
M09339_2.00
Mus musculus
NDDCHWGYYCMRRCHTGYH

DRCADGYYKGRRCWDGHHN
Misc
Kulakovskiy et al.(2013)
P73_MOUSE.H11MO.0.B
0.857 0.857
TP73
M11196_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P73_Q6
0.857 0.857
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000264731 p53 163 359
ENSP00000317510 p53 163 359
ENSP00000346614 p53 69 265
ENSP00000376253 p53 163 359
ENSP00000376254 p53 69 265
ENSP00000376256 p53 69 265
ENSP00000387839 p53 3 180
ENSP00000389485 p53 69 265
ENSP00000392488 p53 69 265
ENSP00000394337 p53 163 359
ENSP00000401661 p53 69 141
ENSP00000401661 p53 148 183
ENSP00000407144 p53 163 359

Links

Other p53 family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

125 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action