TP73 (Homo sapiens)
p53

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00870 (P53) IPR011615 ENSG00000078900 T311039_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
TP73
M08035_2.00
Homo sapiens
RCADGYHSDGRCWDG

CHWGYCHSDRCHTGY
ChIP-seq
Chen et al.(2011)
GSE15704_TP73_rapamycin
(Direct) (Direct)
TP73
M08036_2.00
Homo sapiens
DRRCAWGYHCWGRCWTGYH

DRCAWGYCWGDRCWTGYYH
ChIP-seq
Chen et al.(2011)
GSE15704_TP73_vehicle
(Direct) (Direct)
TP73
M08037_2.00
Homo sapiens
RCMDGYBCHNDCHKG

CMDGHNDGVRCHKGY
ChIP-seq
Chen et al.(2011)
GSE18650_TP73
(Direct) (Direct)
TP73
M09336_2.00
Homo sapiens
NDDCHWGYYCMRRCHTGYH

DRCADGYYKGRRCWDGHHN
Misc
Kulakovskiy et al.(2013)
P73_HUMAN.H11MO.0.A
(Direct) (Direct)
TP73
M11196_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P73_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Trp73
M03438_2.00
Mus musculus
DRCAWGTYNNRACAYGYH

DRCRTGTYNNRACWTGYH
SELEX
Jolma et al.(2013)
Tp73_1
0.980 0.980
Trp73
M09339_2.00
Mus musculus
NDDCHWGYYCMRRCHTGYH

DRCADGYYKGRRCWDGHHN
Misc
Kulakovskiy et al.(2013)
P73_MOUSE.H11MO.0.B
0.980 0.980
Trp63
M09338_2.00
Mus musculus
DRCAWGYHCHRRCHTGYHN

NDRCADGYYDGDRCWTGYH
Misc
Kulakovskiy et al.(2013)
P63_MOUSE.H11MO.0.B
0.857 0.857
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000340740 p53 113 309
ENSP00000346423 p53 113 309
ENSP00000350366 p53 113 309
ENSP00000367529 p53 64 260
ENSP00000367534 p53 64 260
ENSP00000367537 p53 64 260
ENSP00000367539 p53 42 238
ENSP00000367545 p53 113 309
ENSP00000474322 p53 113 309
ENSP00000474626 p53 113 309
ENSP00000475143 p53 113 309

Links

Other p53 family TFs
Other Homo sapiens TFs

124 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
TP73 Gorilla gorilla ENSGGOG00000015559 I 0.995
TP73 Macaca mulatta ENSMMUG00000016569 I 0.990
ENSP00000367545 Macaca fascicularis ENSP00000367545 I 0.990
TP73 Otolemur garnettii ENSOGAG00000006041 I 0.990
ENSPANG00000010294 Papio anubis ENSPANG00000010294 I 0.990
ENSCSAG00000000724 Chlorocebus sabaeus ENSCSAG00000000724 I 0.985
Tp73 Rattus norvegicus ENSRNOG00000024707 I 0.985
TP73 Erinaceus europaeus ENSEEUG00000013128 I 0.980
ENSP00000367545-D1 Bos grunniens ENSP00000367545-D1 I 0.980
TP73 Cavia porcellus ENSCPOG00000010908 I 0.980
ENSSTOG00000029194 Ictidomys tridecemlineatus ENSSTOG00000029194 I 0.980
ENSAPLG00000003880 Anas platyrhynchos ENSAPLG00000003880 I 0.980
Trp73 Mus musculus ENSMUSG00000029026 D 0.980
TP73 Bos taurus ENSBTAG00000005812 I 0.980
TP73 Equus caballus ENSECAG00000000771 I 0.976
Afo_R003301 Aptenodytes forsteri Afo_R003301 I 0.974
Alligator_sinensis_CCG011609.1 Alligator sinensis Alligator_sinensis_CCG011609.1 I 0.974
Aan_R005960 Calypte anna Aan_R005960 I 0.974
ENSSHAG00000005668 Sarcophilus harrisii ENSSHAG00000005668 I 0.970
TP73 Canis familiaris ENSCAFG00000019489 I 0.969
TP73 Procavia capensis ENSPCAG00000000703 I 0.969
TP73 Tursiops truncatus ENSTTRG00000003435 I 0.969
TP73 Anolis carolinensis ENSACAG00000001622 I 0.969
ENSOARG00000015833 Ovis aries ENSOARG00000015833 I 0.969
Cmyd_10015921 Chelonia mydas Cmyd_10015921 I 0.969
Gfo_R009749 Geospiza fortis Gfo_R009749 I 0.964
TP73 Taeniopygia guttata ENSTGUG00000002743 I 0.964
TP73 Felis catus ENSFCAG00000011627 I 0.964
Pvit_15794 Pogona vitticeps Pvit_15794 I 0.964
TP73 Loxodonta africana ENSLAFG00000007013 I 0.964
TP73 Gallus gallus ENSGALG00000001006 I 0.959
ENSPSIG00000004164 Pelodiscus sinensis ENSPSIG00000004164 I 0.959
ENSFALG00000009625 Ficedula albicollis ENSFALG00000009625 I 0.959
ENSMPUG00000007407 Mustela putorius furo ENSMPUG00000007407 I 0.954
Ogr15303 Ophisaurus gracilis Ogr15303 I 0.944
TP73 Meleagris gallopavo ENSMGAG00000001562 I 0.941
ENSPPYG00000001963 Pongo abelii ENSPPYG00000001963 I 0.938
tp73 Xenopus tropicalis XB-GENE-482857 I 0.934
ENSLOCG00000005255 Lepisosteus oculatus ENSLOCG00000005255 I 0.929
ENSLACG00000019068 Latimeria chalumnae ENSLACG00000019068 I 0.929
Brh_R004866 Buceros rhinoceros Brh_R004866 I 0.928
TP73 Pteropus vampyrus ENSPVAG00000008937 I 0.916
ENSXMAG00000017360 Xiphophorus maculatus ENSXMAG00000017360 I 0.909
ENSONIG00000002106 Oreochromis niloticus ENSONIG00000002106 I 0.908
tp73 Danio rerio ENSDARG00000017953 I 0.908
ENSAMXG00000013958 Astyanax mexicanus ENSAMXG00000013958 I 0.903
ENSPFOG00000010828 Poecilia formosa ENSPFOG00000010828 I 0.903
tp73 Takifugu rubripes ENSTRUG00000014931 I 0.893
tp73 Oryzias latipes ENSORLG00000004402 I 0.893
tp73 Gasterosteus aculeatus ENSGACG00000006547 I 0.893
tp73 Tetraodon nigroviridis ENSTNIG00000011978 I 0.892
TP73 Sus scrofa ENSSSCG00000025685 I 0.889
ENSLACG00000014214 Latimeria chalumnae ENSLACG00000014214 I 0.862
TP63 Pan troglodytes ENSPTRG00000015733 I 0.857
TP63 Pteropus vampyrus ENSPVAG00000009056 I 0.857
ENSPPYG00000014401 Pongo abelii ENSPPYG00000014401 I 0.857
TP63 Tursiops truncatus ENSTTRG00000011638 I 0.857
Gfo_R004420 Geospiza fortis Gfo_R004420 I 0.857
ENSP00000264731 Macaca fascicularis ENSP00000264731 I 0.857
Myotis_brandtii_Tp63_10011644 Myotis brandtii Myotis_brandtii_Tp63_10011644 I 0.857
Pvit_07832 Pogona vitticeps Pvit_07832 I 0.857
tp63.L Xenopus laevis XB-GENE-865317 I 0.857
ENSP00000264731-D1 Bos grunniens ENSP00000264731-D1 I 0.857
Afo_R010233 Aptenodytes forsteri Afo_R010233 I 0.857
ENSSTOG00000013771 Ictidomys tridecemlineatus ENSSTOG00000013771 I 0.857
TP63 Sus scrofa ENSSSCG00000025592 I 0.857
TP63 Taeniopygia guttata ENSTGUG00000009377 I 0.857
ENSTSYG00000003709 Tarsius syrichta ENSTSYG00000003709 I 0.857
Aan_R013385 Calypte anna Aan_R013385 I 0.857
Tp63 Rattus norvegicus ENSRNOG00000001924 I 0.857
TP63 Oryctolagus cuniculus ENSOCUG00000016465 I 0.857
TP63 Felis catus ENSFCAG00000000790 I 0.857
ENSFALG00000007393 Ficedula albicollis ENSFALG00000007393 I 0.857
TP63 Equus caballus ENSECAG00000018546 I 0.857
TP63 Homo sapiens ENSG00000073282 D 0.857
TP63 Gallus gallus ENSGALG00000007324 I 0.857
TP63 Meleagris gallopavo ENSMGAG00000007535 I 0.857
TP63 Loxodonta africana ENSLAFG00000031461 I 0.857
Trp63 Dipodomys ordii ENSDORG00000002061 I 0.857
TP63 Dasypus novemcinctus ENSDNOG00000016582 I 0.857
ENSAPLG00000012917 Anas platyrhynchos ENSAPLG00000012917 I 0.857
ENSAMEG00000000763 Ailuropoda melanoleuca ENSAMEG00000000763 I 0.857
TP63 Bos taurus ENSBTAG00000015460 I 0.857
TP63 Canis familiaris ENSCAFG00000013961 I 0.857
TP63 Cavia porcellus ENSCPOG00000014770 I 0.857
TP63 Callithrix jacchus ENSCJAG00000014256 I 0.857
TP63 Microcebus murinus ENSMICG00000005240 I 0.857
TP63 Gorilla gorilla ENSGGOG00000005113 I 0.857
TP63 Ornithorhynchus anatinus ENSOANG00000013795 I 0.857
ENSNLEG00000006723 Nomascus leucogenys ENSNLEG00000006723 I 0.857
Trp63 Mus musculus ENSMUSG00000022510 D 0.857
ENSOARG00000020478 Ovis aries ENSOARG00000020478 I 0.857
TP63 Myotis lucifugus ENSMLUG00000015597 I 0.857
TP63 Procavia capensis ENSPCAG00000005011 I 0.857
ENSPANG00000006656 Papio anubis ENSPANG00000006656 I 0.857
ENSMPUG00000003438 Mustela putorius furo ENSMPUG00000003438 I 0.857
TP63 Otolemur garnettii ENSOGAG00000003838 I 0.857
TP63 Monodelphis domestica ENSMODG00000015060 I 0.857
TP63 Macaca mulatta ENSMMUG00000016466 I 0.857
Brh_R005208 Buceros rhinoceros Brh_R005208 I 0.855
Tal_R007660 Tyto alba Tal_R007660 I 0.855
ENSLOCG00000005148 Lepisosteus oculatus ENSLOCG00000005148 I 0.852
ENSPSIG00000016009 Pelodiscus sinensis ENSPSIG00000016009 I 0.852
TP63 Sorex araneus ENSSARG00000012752 I 0.852
ENSACAG00000002961 Anolis carolinensis ENSACAG00000002961 I 0.848
tp63 Oryzias latipes ENSORLG00000015665 I 0.847
tp63 Xenopus tropicalis XB-GENE-479868 I 0.842
tp63 Takifugu rubripes ENSTRUG00000003420 I 0.842
ENSONIG00000019325 Oreochromis niloticus ENSONIG00000019325 I 0.842
ENSGACG00000013629 Gasterosteus aculeatus ENSGACG00000013629 I 0.842
ENSXMAG00000016425 Xiphophorus maculatus ENSXMAG00000016425 I 0.842
tp63 Tetraodon nigroviridis ENSTNIG00000013774 I 0.842
tp63 Danio rerio ENSDARG00000044356 I 0.842
ENSAMXG00000004843 Astyanax mexicanus ENSAMXG00000004843 I 0.842
ENSPFOG00000000910 Poecilia formosa ENSPFOG00000000910 I 0.842
TP63 Choloepus hoffmanni ENSCHOG00000010497 I 0.839
ENSGMOG00000000413 Gadus morhua ENSGMOG00000000413 I 0.837
ENSAMEG00000009237 Ailuropoda melanoleuca ENSAMEG00000009237 I 0.836
Ogr07265 Ophisaurus gracilis Ogr07265 I 0.820
ENSCSAG00000009062 Chlorocebus sabaeus ENSCSAG00000009062 I 0.815
ENSMEUG00000000762 Macropus eugenii ENSMEUG00000000762 I 0.752
ENSPMAG00000009535 Petromyzon marinus ENSPMAG00000009535 I 0.714
TP73 Callithrix jacchus ENSCJAG00000002773 I 0.714