Trp73 (Mus musculus)
p53

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00870 (P53) IPR011615 ENSMUSG00000029026 T311092_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Trp73
M03438_2.00		 Mus musculus
DRCAWGTYNNRACAYGYH
DRCRTGTYNNRACWTGYH		 SELEX
Jolma et al.(2013)
Tp73_1		 (Direct) (Direct)
Trp73
M09339_2.00		 Mus musculus
NDDCHWGYYCMRRCHTGYH
DRCADGYYKGRRCWDGHHN		 Misc
Kulakovskiy et al.(2013)
P73_MOUSE.H11MO.0.B		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
TP73
M08035_2.00 		Homo sapiens
RCADGYHSDGRCWDG
CHWGYCHSDRCHTGY		 ChIP-seq
Chen et al.(2011)
GSE15704_TP73_rapamycin 		1.000 1.000
TP73
M08036_2.00 		Homo sapiens
DRRCAWGYHCWGRCWTGYH
DRCAWGYCWGDRCWTGYYH		 ChIP-seq
Chen et al.(2011)
GSE15704_TP73_vehicle 		1.000 1.000
TP73
M08037_2.00 		Homo sapiens
RCMDGYBCHNDCHKG
CMDGHNDGVRCHKGY		 ChIP-seq
Chen et al.(2011)
GSE18650_TP73 		1.000 1.000
TP73
M09336_2.00 		Homo sapiens
NDDCHWGYYCMRRCHTGYH
DRCADGYYKGRRCWDGHHN		 Misc
Kulakovskiy et al.(2013)
P73_HUMAN.H11MO.0.A 		1.000 1.000
TP73
M11196_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$P73_Q6 		0.980 0.980
Trp63
M09338_2.00 		Mus musculus
DRCAWGYHCHRRCHTGYHN
NDRCADGYYDGDRCWTGYH		 Misc
Kulakovskiy et al.(2013)
P63_MOUSE.H11MO.0.B 		0.887 0.887
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000095368 p53 64 260
ENSMUSP00000101268 p53 64 260
ENSMUSP00000101269 p53 112 308
ENSMUSP00000114418 p53 64 260
ENSMUSP00000114736 p53 152 204
ENSMUSP00000134196 p53 64 260
ENSMUSP00000135281 p53 42 213

Links

Other p53 family TFs
Other Mus musculus TFs

126 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
TP73 Erinaceus europaeus ENSEEUG00000013128 I 1.000
TP73 Callithrix jacchus ENSCJAG00000002773 I 1.000
Tp73 Rattus norvegicus ENSRNOG00000024707 I 0.995
TP73 Macaca mulatta ENSMMUG00000016569 I 0.990
TP73 Otolemur garnettii ENSOGAG00000006041 I 0.990
ENSP00000367545 Macaca fascicularis ENSP00000367545 I 0.990
ENSPANG00000010294 Papio anubis ENSPANG00000010294 I 0.985
TP73 Gorilla gorilla ENSGGOG00000015559 I 0.985
ENSCSAG00000000724 Chlorocebus sabaeus ENSCSAG00000000724 I 0.985
TP73 Homo sapiens ENSG00000078900 D 0.980
ENSSTOG00000029194 Ictidomys tridecemlineatus ENSSTOG00000029194 I 0.980
TP73 Cavia porcellus ENSCPOG00000010908 I 0.969
ENSP00000367545-D1 Bos grunniens ENSP00000367545-D1 I 0.969
TP73 Bos taurus ENSBTAG00000005812 I 0.969
Alligator_sinensis_CCG011609.1 Alligator sinensis Alligator_sinensis_CCG011609.1 I 0.964
Afo_R003301 Aptenodytes forsteri Afo_R003301 I 0.964
TP73 Equus caballus ENSECAG00000000771 I 0.964
Aan_R005960 Calypte anna Aan_R005960 I 0.964
ENSAPLG00000003880 Anas platyrhynchos ENSAPLG00000003880 I 0.959
Cmyd_10015921 Chelonia mydas Cmyd_10015921 I 0.959
ENSOARG00000015833 Ovis aries ENSOARG00000015833 I 0.959
TP73 Tursiops truncatus ENSTTRG00000003435 I 0.959
TP73 Canis familiaris ENSCAFG00000019489 I 0.959
TP73 Anolis carolinensis ENSACAG00000001622 I 0.959
TP73 Procavia capensis ENSPCAG00000000703 I 0.959
ENSSHAG00000005668 Sarcophilus harrisii ENSSHAG00000005668 I 0.958
TP73 Loxodonta africana ENSLAFG00000007013 I 0.954
TP73 Taeniopygia guttata ENSTGUG00000002743 I 0.954
TP73 Felis catus ENSFCAG00000011627 I 0.954
Pvit_15794 Pogona vitticeps Pvit_15794 I 0.954
Gfo_R009749 Geospiza fortis Gfo_R009749 I 0.954
ENSPSIG00000004164 Pelodiscus sinensis ENSPSIG00000004164 I 0.949
ENSFALG00000009625 Ficedula albicollis ENSFALG00000009625 I 0.949
TP73 Gallus gallus ENSGALG00000001006 I 0.949
ENSMPUG00000007407 Mustela putorius furo ENSMPUG00000007407 I 0.944
Ogr15303 Ophisaurus gracilis Ogr15303 I 0.935
ENSAMEG00000009237 Ailuropoda melanoleuca ENSAMEG00000009237 I 0.930
TP73 Meleagris gallopavo ENSMGAG00000001562 I 0.929
ENSLACG00000019068 Latimeria chalumnae ENSLACG00000019068 I 0.929
ENSPFOG00000010828 Poecilia formosa ENSPFOG00000010828 I 0.925
ENSPPYG00000001963 Pongo abelii ENSPPYG00000001963 I 0.924
tp73 Xenopus tropicalis XB-GENE-482857 I 0.923
Brh_R004866 Buceros rhinoceros Brh_R004866 I 0.918
ENSLOCG00000005255 Lepisosteus oculatus ENSLOCG00000005255 I 0.918
ENSONIG00000002106 Oreochromis niloticus ENSONIG00000002106 I 0.906
TP73 Pteropus vampyrus ENSPVAG00000008937 I 0.905
ENSXMAG00000017360 Xiphophorus maculatus ENSXMAG00000017360 I 0.903
tp73 Danio rerio ENSDARG00000017953 I 0.903
ENSAMXG00000013958 Astyanax mexicanus ENSAMXG00000013958 I 0.893
TP73 Sus scrofa ENSSSCG00000025685 I 0.889
tp73 Oryzias latipes ENSORLG00000004402 I 0.888
tp73 Takifugu rubripes ENSTRUG00000014931 I 0.888
tp73 Tetraodon nigroviridis ENSTNIG00000011978 I 0.887
Myotis_brandtii_Ccdc27_10023983 Myotis brandtii Myotis_brandtii_Ccdc27_10023983 I 0.886
tp73 Gasterosteus aculeatus ENSGACG00000006547 I 0.883
tp63 Xenopus tropicalis XB-GENE-479868 I 0.868
tp63 Danio rerio ENSDARG00000044356 I 0.868
TP63 Pan troglodytes ENSPTRG00000015733 I 0.860
ENSPPYG00000014401 Pongo abelii ENSPPYG00000014401 I 0.860
TP63 Pteropus vampyrus ENSPVAG00000009056 I 0.860
Tp63 Rattus norvegicus ENSRNOG00000001924 I 0.860
Aan_R013385 Calypte anna Aan_R013385 I 0.860
Gfo_R004420 Geospiza fortis Gfo_R004420 I 0.860
ENSP00000264731 Macaca fascicularis ENSP00000264731 I 0.860
Myotis_brandtii_Tp63_10011644 Myotis brandtii Myotis_brandtii_Tp63_10011644 I 0.860
Pvit_07832 Pogona vitticeps Pvit_07832 I 0.860
tp63.L Xenopus laevis XB-GENE-865317 I 0.860
ENSP00000264731-D1 Bos grunniens ENSP00000264731-D1 I 0.860
Afo_R010233 Aptenodytes forsteri Afo_R010233 I 0.860
ENSSTOG00000013771 Ictidomys tridecemlineatus ENSSTOG00000013771 I 0.860
TP63 Taeniopygia guttata ENSTGUG00000009377 I 0.860
ENSTSYG00000003709 Tarsius syrichta ENSTSYG00000003709 I 0.860
TP63 Tursiops truncatus ENSTTRG00000011638 I 0.860
TP63 Sus scrofa ENSSSCG00000025592 I 0.860
TP63 Oryctolagus cuniculus ENSOCUG00000016465 I 0.860
TP63 Meleagris gallopavo ENSMGAG00000007535 I 0.860
ENSAPLG00000012917 Anas platyrhynchos ENSAPLG00000012917 I 0.860
TP63 Cavia porcellus ENSCPOG00000014770 I 0.860
TP63 Microcebus murinus ENSMICG00000005240 I 0.860
TP63 Macaca mulatta ENSMMUG00000016466 I 0.860
TP63 Myotis lucifugus ENSMLUG00000015597 I 0.860
TP63 Felis catus ENSFCAG00000000790 I 0.860
TP63 Loxodonta africana ENSLAFG00000031461 I 0.860
TP63 Gorilla gorilla ENSGGOG00000005113 I 0.860
TP63 Gallus gallus ENSGALG00000007324 I 0.860
TP63 Canis familiaris ENSCAFG00000013961 I 0.860
TP63 Homo sapiens ENSG00000073282 D 0.860
TP63 Bos taurus ENSBTAG00000015460 I 0.860
TP63 Callithrix jacchus ENSCJAG00000014256 I 0.860
TP63 Monodelphis domestica ENSMODG00000015060 I 0.860
TP63 Equus caballus ENSECAG00000018546 I 0.860
ENSAMEG00000000763 Ailuropoda melanoleuca ENSAMEG00000000763 I 0.860
ENSPANG00000006656 Papio anubis ENSPANG00000006656 I 0.860
Trp63 Dipodomys ordii ENSDORG00000002061 I 0.860
TP63 Dasypus novemcinctus ENSDNOG00000016582 I 0.860
TP63 Procavia capensis ENSPCAG00000005011 I 0.860
TP63 Otolemur garnettii ENSOGAG00000003838 I 0.860
ENSOARG00000020478 Ovis aries ENSOARG00000020478 I 0.860
ENSNLEG00000006723 Nomascus leucogenys ENSNLEG00000006723 I 0.860
TP63 Ornithorhynchus anatinus ENSOANG00000013795 I 0.860
ENSMPUG00000003438 Mustela putorius furo ENSMPUG00000003438 I 0.860
ENSFALG00000007393 Ficedula albicollis ENSFALG00000007393 I 0.860
Trp63 Mus musculus ENSMUSG00000022510 D 0.860
Brh_R005208 Buceros rhinoceros Brh_R005208 I 0.855
Tal_R007660 Tyto alba Tal_R007660 I 0.855
ENSPSIG00000016009 Pelodiscus sinensis ENSPSIG00000016009 I 0.854
TP63 Sorex araneus ENSSARG00000012752 I 0.854
ENSLOCG00000005148 Lepisosteus oculatus ENSLOCG00000005148 I 0.854
ENSACAG00000002961 Anolis carolinensis ENSACAG00000002961 I 0.848
tp63 Oryzias latipes ENSORLG00000015665 I 0.848
ENSLACG00000014214 Latimeria chalumnae ENSLACG00000014214 I 0.848
ENSAMXG00000004843 Astyanax mexicanus ENSAMXG00000004843 I 0.842
ENSXMAG00000016425 Xiphophorus maculatus ENSXMAG00000016425 I 0.842
ENSPFOG00000000910 Poecilia formosa ENSPFOG00000000910 I 0.842
tp63 Takifugu rubripes ENSTRUG00000003420 I 0.842
tp63 Tetraodon nigroviridis ENSTNIG00000013774 I 0.842
ENSGACG00000013629 Gasterosteus aculeatus ENSGACG00000013629 I 0.842
ENSONIG00000019325 Oreochromis niloticus ENSONIG00000019325 I 0.842
TP63 Choloepus hoffmanni ENSCHOG00000010497 I 0.839
ENSGMOG00000000413 Gadus morhua ENSGMOG00000000413 I 0.837
Ogr07265 Ophisaurus gracilis Ogr07265 I 0.820
ENSCSAG00000009062 Chlorocebus sabaeus ENSCSAG00000009062 I 0.815
ENSMEUG00000000762 Macropus eugenii ENSMEUG00000000762 I 0.744
ENSPMAG00000009535 Petromyzon marinus ENSPMAG00000009535 I 0.719
ENSACAG00000022533 Anolis carolinensis ENSACAG00000022533 I 0.708