|
|
Trp73
(Mus musculus)
p53
|
TF Information |
|---|
| Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
Animal TF db |
| PF00870 (P53) |
IPR011615 |
ENSMUSG00000029026 |
T311092_2.00 |
Ensembl (2018-Dec-8) |
Link out |
| NCBI Gene Info:This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq, Jul 2008] |
Directly determined binding motifs |
|---|
| Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR
Score |
DBD
Identity |
Trp73
M03438_2.00 |
Mus musculus |
DRCAWGTYNNRACAYGYH |
DRCRTGTYNNRACWTGYH |
SELEX
Jolma et al.(2013)
Tp73_1 |
(Direct) |
(Direct) |
Trp73
M09339_2.00 |
Mus musculus |
NDDCHWGYYCMRRCHTGYH |
DRCADGYYKGRRCWDGHHN |
Misc
Kulakovskiy et al.(2013)
P73_MOUSE.H11MO.0.B |
(Direct) |
(Direct) |
Motifs from related TFs |
|---|
| Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR
Score |
DBD
Identity |
TP73
M08035_2.00 |
Homo sapiens |
RCADGYHSDGRCWDG |
CHWGYCHSDRCHTGY |
ChIP-seq
Chen et al.(2011)
GSE15704_TP73_rapamycin
|
1.000
|
1.000
|
TP73
M08036_2.00 |
Homo sapiens |
DRRCAWGYHCWGRCWTGYH |
DRCAWGYCWGDRCWTGYYH |
ChIP-seq
Chen et al.(2011)
GSE15704_TP73_vehicle
|
1.000
|
1.000
|
TP73
M08037_2.00 |
Homo sapiens |
RCMDGYBCHNDCHKG |
CMDGHNDGVRCHKGY |
ChIP-seq
Chen et al.(2011)
GSE18650_TP73
|
1.000
|
1.000
|
TP73
M09336_2.00 |
Homo sapiens |
NDDCHWGYYCMRRCHTGYH |
DRCADGYYKGRRCWDGHHN |
Misc
Kulakovskiy et al.(2013)
P73_HUMAN.H11MO.0.A
|
1.000
|
1.000
|
TP73
M11196_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$P73_Q6
|
0.977
|
0.977
|
Trp63
M09338_2.00 |
Mus musculus |
DRCAWGYHCHRRCHTGYHN |
NDRCADGYYDGDRCWTGYH |
Misc
Kulakovskiy et al.(2013)
P63_MOUSE.H11MO.0.B
|
0.860
|
0.860
|
| For this family, TFs with SR scores > 0.700 will likely have a similar motif |