TF Information

Tp63 *(Rattus norvegicus)* p53
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00870 (P53)	IPR011615	ENSRNOG00000001924	T311140_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.[provided by RefSeq, Dec 2009]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
No direct experiments
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Trp63 M09338_2.00	Mus musculus	DRCAWGYHCHRRCHTGYHN	NDRCADGYYDGDRCWTGYH	Misc Kulakovskiy et al.(2013) P63_MOUSE.H11MO.0.B	1.000	1.000
Trp73 M03438_2.00	Mus musculus	DRCAWGTYNNRACAYGYH	DRCRTGTYNNRACWTGYH	SELEX Jolma et al.(2013) Tp73_1	0.857	0.857
TP73 M08035_2.00	Homo sapiens	RCADGYHSDGRCWDG	CHWGYCHSDRCHTGY	ChIP-seq Chen et al.(2011) GSE15704_TP73_rapamycin	0.857	0.857
TP73 M08036_2.00	Homo sapiens	DRRCAWGYHCWGRCWTGYH	DRCAWGYCWGDRCWTGYYH	ChIP-seq Chen et al.(2011) GSE15704_TP73_vehicle	0.857	0.857
TP73 M08037_2.00	Homo sapiens	RCMDGYBCHNDCHKG	CMDGHNDGVRCHKGY	ChIP-seq Chen et al.(2011) GSE18650_TP73	0.857	0.857
TP73 M09336_2.00	Homo sapiens	NDDCHWGYYCMRRCHTGYH	DRCADGYYKGRRCWDGHHN	Misc Kulakovskiy et al.(2013) P73_HUMAN.H11MO.0.A	0.857	0.857
Trp73 M09339_2.00	Mus musculus	NDDCHWGYYCMRRCHTGYH	DRCADGYYKGRRCWDGHHN	Misc Kulakovskiy et al.(2013) P73_MOUSE.H11MO.0.B	0.857	0.857
TP73 M11196_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$P73_Q6	0.857	0.857
For this family, TFs with SR scores > 0.700* will likely have a similar motif*

DNA Binding Domains

Protein ID	Domain	From	To	Sequence
ENSRNOP00000002636	p53	69	265	PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSRNOP00000032308	p53	163	359	PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSRNOP00000033463	p53	163	359	PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSRNOP00000059178	p53	163	359	PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSRNOP00000061884	p53	69	265	PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI

Links
Other p53 family TFs
Other *Rattus norvegicus* TFs

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123 Related TFs

Name	Species	Gene ID	Motif Evidence	SR Score	Action