Tp53 (Rattus norvegicus)
p53

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00870 (P53) IPR011615 ENSRNOG00000010756 T311141_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it is believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Alternatively spliced transcript variants have been found for this gene, but the biological validity of the variants has not been determined. p53 pseudogenes have been found on chromosomes 9 and 18. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Trp53
M03439_2.00 		Mus musculus
ACWTGYYNHHDSACWTGT
ACAWGTSHDDNRRCAWGT		 SELEX
Jolma et al.(2013)
Tp53_1 		0.938 0.938
Trp53
M03440_2.00 		Mus musculus
ACWTGTYHNNGACWTGT
ACAWGTCNNDRACAWGT		 SELEX
Jolma et al.(2013)
Tp53_2 		0.938 0.938
Trp53
M03441_2.00 		Mus musculus
RACATGYCYRGRCATGTY
RACATGYCYRGRCATGTY		 SELEX
Jolma et al.(2013)
Tp53_3 		0.871 0.871
Trp53
M09340_2.00 		Mus musculus
RRRCAWGYCCRGRCADGYMH
DKRCHTGYCYGGRCWTGYYY		 Misc
Kulakovskiy et al.(2013)
P53_MOUSE.H11MO.0.A 		0.871 0.871
TP53
M09337_2.00 		Homo sapiens
DRRCWTGYYCAGRCATGYYY
RRRCATGYCTGRRCAWGYYH		 Misc
Kulakovskiy et al.(2013)
P53_HUMAN.H11MO.0.A 		0.848 0.848
TP53
M09621_2.00 		Homo sapiens
NNDRCAWGYHNNDRCWWGYH
DRCWWGYHNNDRCWTGYHNN		 Misc
Heinz et al.(2010)
Saos-p53 		0.848 0.848
TP53
M11197_2.00 		Homo sapiens
RGACATGCCCGGGCATGTYC
GRACATGCCCGGGCATGTCY		 Transfac
Matys et al.(2006)
V$P53_01 		0.848 0.848
TP53
M11198_2.00 		Homo sapiens
NGRCWTGYYY
RRRCAWGYCN		 Transfac
Matys et al.(2006)
V$P53_02 		0.908 0.908
TP53
M11199_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$P53_03 		0.908 0.908
TP53
M11200_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$P53_04 		0.908 0.908
TP53
M11201_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$P53_05 		0.848 0.848
TP53
M11202_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$P53_Q3_01 		0.848 0.848
TP53
M11203_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$P53_Q3 		0.848 0.848
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSRNOP00000047840 p53 93 287
ENSRNOP00000068796 p53 93 271
ENSRNOP00000074031 p53 93 287

Links

Other p53 family TFs
Other Rattus norvegicus TFs

50 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
Trp53 Mus musculus ENSMUSG00000059552 D 0.938
TP53 Homo sapiens ENSG00000141510 D 0.924
ENSOCUG00000001138 Oryctolagus cuniculus ENSOCUG00000001138 I 0.923
ENSSTOG00000022774 Ictidomys tridecemlineatus ENSSTOG00000022774 I 0.913
ENSPPYG00000007934 Pongo abelii ENSPPYG00000007934 I 0.913
TP53 Pan troglodytes ENSPTRG00000008703 I 0.908
TP53 Gorilla gorilla ENSGGOG00000009786 I 0.908
ENSPANG00000024061 Papio anubis ENSPANG00000024061 I 0.897
TP53 Macaca mulatta ENSMMUG00000008639 I 0.897
TP53 Callithrix jacchus ENSCJAG00000014978 I 0.897
ENSCSAG00000011345 Chlorocebus sabaeus ENSCSAG00000011345 I 0.897
ENSP00000269305 Macaca fascicularis ENSP00000269305 I 0.897
TP53 Ochotona princeps ENSOPRG00000006441 I 0.892
LOC100910954 Rattus norvegicus ENSRNOG00000046657 I 0.888
TP53 Tursiops truncatus ENSTTRG00000010250 I 0.883
ENSNLEG00000009730 Nomascus leucogenys ENSNLEG00000009730 I 0.882
TP53 Cavia porcellus ENSCPOG00000014252 I 0.882
TP53 Sus scrofa ENSSSCG00000017950 I 0.882
ENSAMEG00000016851 Ailuropoda melanoleuca ENSAMEG00000016851 I 0.877
ENSOARG00000015571 Ovis aries ENSOARG00000015571 I 0.872
TP53 Bos taurus ENSBTAG00000001069 I 0.872
ENSBTAP00000001420-D1 Bos grunniens ENSBTAP00000001420-D1 I 0.872
TP53 Microcebus murinus ENSMICG00000014853 I 0.872
TP53 Canis familiaris ENSCAFG00000016714 I 0.872
TP53 Felis catus ENSFCAG00000009623 I 0.872
TP53 Otolemur garnettii ENSOGAG00000016871 I 0.867
TP53 Procavia capensis ENSPCAG00000012725 I 0.862
ENSMPUG00000009017 Mustela putorius furo ENSMPUG00000009017 I 0.862
TP53 Dasypus novemcinctus ENSDNOG00000005252 I 0.857
ENSMLUG00000006411 Myotis lucifugus ENSMLUG00000006411 I 0.856
Myotis_brandtii_TP53_10021059 Myotis brandtii Myotis_brandtii_TP53_10021059 I 0.856
TP53 Sorex araneus ENSSARG00000006206 I 0.846
ENSSHAG00000015510 Sarcophilus harrisii ENSSHAG00000015510 I 0.841
ENSOCUG00000022109 Oryctolagus cuniculus ENSOCUG00000022109 I 0.836
ENSLAFG00000007483 Loxodonta africana ENSLAFG00000007483 I 0.832
TP53 Erinaceus europaeus ENSEEUG00000014573 I 0.831
ENSMEUG00000013135 Macropus eugenii ENSMEUG00000013135 I 0.831
ENSETEG00000008987 Echinops telfairi ENSETEG00000008987 I 0.823
ENSMLUG00000025140 Myotis lucifugus ENSMLUG00000025140 I 0.768
TP53 Equus caballus ENSECAG00000008126 I 0.764
ENSLAFG00000030880 Loxodonta africana ENSLAFG00000030880 I 0.730
ENSLAFG00000032042 Loxodonta africana ENSLAFG00000032042 I 0.724
ENSACAG00000022533 Anolis carolinensis ENSACAG00000022533 I 0.723
Cmyd_10000491 Chelonia mydas Cmyd_10000491 I 0.718
ENSOANG00000011981 Ornithorhynchus anatinus ENSOANG00000011981 N 0.718
ENSLAFG00000028299 Loxodonta africana ENSLAFG00000028299 I 0.713
ENSPSIG00000013302 Pelodiscus sinensis ENSPSIG00000013302 I 0.708
tp53 Danio rerio ENSDARG00000035559 I 0.708
Pvit_02042 Pogona vitticeps Pvit_02042 N 0.702