CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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ENSP00000367545
(
Macaca fascicularis
)
p53
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
PF00870 (P53)
IPR011615
ENSP00000367545
T311236_2.00
GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Trp73
M03438_2.00
Mus musculus
DRCAWGTYNNRACAYGYH
DRCRTGTYNNRACWTGYH
SELEX
Jolma et al.(2013)
Tp73_1
0.990
0.990
TP73
M08035_2.00
Homo sapiens
RCADGYHSDGRCWDG
CHWGYCHSDRCHTGY
ChIP-seq
Chen et al.(2011)
GSE15704_TP73_rapamycin
0.990
0.990
TP73
M08036_2.00
Homo sapiens
DRRCAWGYHCWGRCWTGYH
DRCAWGYCWGDRCWTGYYH
ChIP-seq
Chen et al.(2011)
GSE15704_TP73_vehicle
0.990
0.990
TP73
M08037_2.00
Homo sapiens
RCMDGYBCHNDCHKG
CMDGHNDGVRCHKGY
ChIP-seq
Chen et al.(2011)
GSE18650_TP73
0.990
0.990
TP73
M09336_2.00
Homo sapiens
NDDCHWGYYCMRRCHTGYH
DRCADGYYKGRRCWDGHHN
Misc
Kulakovskiy et al.(2013)
P73_HUMAN.H11MO.0.A
0.990
0.990
Trp73
M09339_2.00
Mus musculus
NDDCHWGYYCMRRCHTGYH
DRCADGYYKGRRCWDGHHN
Misc
Kulakovskiy et al.(2013)
P73_MOUSE.H11MO.0.B
0.990
0.990
TP73
M11196_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P73_Q6
0.990
0.990
Trp63
M09338_2.00
Mus musculus
DRCAWGYHCHRRCHTGYHN
NDRCADGYYDGDRCWTGYH
Misc
Kulakovskiy et al.(2013)
P63_MOUSE.H11MO.0.B
0.857
0.857
For this family, TFs with SR scores >
0.700
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000367545
p53
113
309
PVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDIVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLETRDGQVLGRRSFEGRICACPGRDRKADEDHY
Links
Other
p53
family TFs
Other
Macaca fascicularis
TFs
124 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy