PAX1 (Homo sapiens)
Paired box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00292 (PAX) IPR001523 ENSG00000125813 T311643_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. This gene plays a role in pattern formation during embryogenesis and may be essential for development of the vertebral column. This gene is silenced by methylation in ovarian and cervical cancers and may be a tumor suppressor gene. Mutations in this gene are also associated with vertebral malformations. [provided by RefSeq, Mar 2012]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
PAX1
M03442_2.00
Homo sapiens
DBCANTSAWGCGTGACS

SGTCACGCWTSANTGVH
SELEX
Jolma et al.(2013)
PAX1_1
(Direct) (Direct)
PAX1
M05687_2.00
Homo sapiens
BCRNTSRWGCGTGACSN

NSGTCACGCWYSANYGV
SELEX
Yin et al.(2017)
PAX1_eDBD_HT-SELEX
(Direct) (Direct)
PAX1
M05688_2.00
Homo sapiens
BCRNTSAWGCGTGACSN

NSGTCACGCWTSANYGV
SELEX
Yin et al.(2017)
PAX1_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
PAX1
M11207_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PAX1_B
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
PAX9
M03444_2.00
Homo sapiens
NKCANTSAWGCGTGACS

SGTCACGCWTSANTGMN
SELEX
Jolma et al.(2013)
PAX9_1
0.960 0.960
PAX9
M05689_2.00
Homo sapiens
BHRNYSRDSCGTRACSN

NSGTYACGSHYSRNYDV
SELEX
Yin et al.(2017)
PAX9_eDBD_HT-SELEX
0.960 0.960
PAX9
M05690_2.00
Homo sapiens
BCRNTSAWSCGYGACNN

NNGTCRCGSWTSANYGV
SELEX
Yin et al.(2017)
PAX9_eDBD_Methyl-HT-SELEX
0.960 0.960
pax9
M11204_2.00
Danio rerio Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PAX9_B
0.952 0.952
Poxm
M03944_2.00
Drosophila melanogaster
CAVTCAWGCGTGACR

YGTCACGCWTGABTG
SELEX
Nitta et al.(2015)
Poxm_1
0.880 0.880
Poxm
M03945_2.00
Drosophila melanogaster
NYSAWGCRTRACS

SGTYAYGCWTSRN
SELEX
Nitta et al.(2015)
Poxm_2
0.880 0.880
Poxm
M06436_2.00
Drosophila melanogaster
NNNNNNMVNHNRNSCRTGA

TCAYGSNYNDNBKNNNNNN
B1H
Zhu et al.(2011)
Poxm_SOLEXA_5_FBgn0003129
0.880 0.880
PAX7
M00346_2.00
Homo sapiens
NGTYAYGSHN

NDSCRTRACN
PBM
Barrera et al.(2016)
PAX7_REF
0.752 0.752
pax2b
M02425_2.00
Danio rerio
HVNYSRNSCR

YGSNYSRNBD
PBM
Weirauch et al.(2014)
pTH8679
0.744 0.744
PAX7
M00345_2.00
Homo sapiens
NSGTCACGSN

NSCGTGACSN
PBM
Barrera et al.(2016)
PAX7_P112L
0.744 0.744
Pax5B
M01301_2.00
Gallus gallus
NSNDTNNNN

NNNNAHNSN
PBM
Lambert et al.(2019)
pTH9781
0.736 0.736
pax2
M02428_2.00
Xenopus tropicalis
NNNRNBCRNN

NNYGVNYNNN
PBM
Weirauch et al.(2014)
pTH8556
0.736 0.736
PAX5
M03443_2.00
Homo sapiens
RNBYANYSAWSCGTRACN

NGTYACGSWTSRNTRVNY
SELEX
Jolma et al.(2013)
PAX5_1
0.736 0.736
PAX5
M08160_2.00
Homo sapiens
RDGCGTGACCNN

NNGGTCACGCHY
ChIP-seq
Mathelier et al.(2014)
MA0014.3
0.736 0.736
PAX5
M07995_2.00
Homo sapiens
BCAVYSRDSCRKRRC

GYYMYGSHYSRBTGV
ChIP-seq
Gerstein et al.(2012)
GM12878_PAX5C20_HudsonAlpha
0.736 0.736
PAX5
M07996_2.00
Homo sapiens
BCASYSRDSCRTRAC

GTYAYGSHYSRSTGV
ChIP-seq
Gerstein et al.(2012)
GM12878_PAX5N19_HudsonAlpha
0.736 0.736
PAX5
M07997_2.00
Homo sapiens
CASYSRDSCRKRACN

NGTYMYGSHYSRSTG
ChIP-seq
Gerstein et al.(2012)
GM12891_PAX5C20_HudsonAlpha
0.736 0.736
PAX5
M07998_2.00
Homo sapiens
BCASYSRDSCGKRRC

GYYMCGSHYSRSTGV
ChIP-seq
Gerstein et al.(2012)
GM12892_PAX5C20_HudsonAlpha
0.736 0.736
PAX5
M08227_2.00
Homo sapiens
BCANYSRDGCGTRAM

KTYACGCHYSRNTGV
ChIP-seq
Contrino et al.(2012)
Mv108
0.736 0.736
PAX5
M08228_2.00
Homo sapiens
AGCGTGRCYG

CRGYCACGCT
ChIP-seq
Contrino et al.(2012)
Mv109
0.736 0.736
PAX5
M09341_2.00
Homo sapiens
SNVDGNKCARCVRAGCRDGAC

GTCHYGCTYBGYTGMNCHBNS
Misc
Kulakovskiy et al.(2013)
PAX5_HUMAN.H11MO.0.A
0.736 0.736
Pax5
M09342_2.00
Mus musculus
VDRNBCAVYVRDSCRKRRM

KYYMYGSHYBRBTGVNYHB
Misc
Kulakovskiy et al.(2013)
PAX5_MOUSE.H11MO.0.A
0.736 0.736
PAX5
M09622_2.00
Homo sapiens
BCASYSRDSCRTGRMN

NKYCAYGSHYSRSTGV
Misc
Heinz et al.(2010)
GM12878-PAX5_GSE32465_1
0.736 0.736
PAX5
M09623_2.00
Homo sapiens
BCABNVRSCGTGAC

GTCACGSYBNVTGV
Misc
Heinz et al.(2010)
GM12878-PAX5_GSE32465_2
0.736 0.736
PAX5
M11208_2.00
Homo sapiens
BCNNNRNKCANBGNWGNRKRGMSRSHNB

VNDSYSKCYMYNCWNCVNTGMNYNNNGV
Transfac
Matys et al.(2006)
V$PAX5_01
0.736 0.736
PAX5
M11209_2.00
Homo sapiens
VRHVDGDNDBBTNRAGCGKRACVRYNVH

DBNRYBGTYMCGCTYNAVVHNHCHBDYB
Transfac
Matys et al.(2006)
V$PAX5_02
0.736 0.736
PAX5
M11210_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PAX5_06
0.736 0.736
PAX5
M11211_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PAX5_07
0.736 0.736
PAX5
M11212_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PAX5_Q6
0.736 0.736
PAX8
M05685_2.00
Homo sapiens
NRNBYRNYSRWGCGTGACSN

NSGTCACGCWYSRNYRVNYN
SELEX
Yin et al.(2017)
PAX8_FL_HT-SELEX
0.728 0.728
Pax8
M09624_2.00
Rattus norvegicus
BCAGBCADSCRKGVM

KBCMYGSHTGVCTGV
Misc
Heinz et al.(2010)
Thyroid-Pax8_GSE26938
0.728 0.728
PAX8
M11205_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PAX8_01
0.728 0.728
PAX8
M11206_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PAX8_B
0.728 0.728
PAX8
M05686_2.00
Homo sapiens
NRNBCRNTSAWSCGYGACNN

NNGTCRCGSWTSANYGVNYN
SELEX
Yin et al.(2017)
PAX8_FL_Methyl-HT-SELEX
0.728 0.728
sv
M01302_2.00
Drosophila melanogaster
NNNSCRBRDM

KHYVYGSNNN
PBM
Lambert et al.(2019)
pTH9773
0.712 0.712
sv
M03949_2.00
Drosophila melanogaster
NBCRNYSAWGCGTGACS

SGTCACGCWTSRNYGVN
SELEX
Nitta et al.(2015)
sv_1
0.712 0.712
sv
M06438_2.00
Drosophila melanogaster
RNYSRDSCGTRACNN

NNGTYACGSHYSRNY
B1H
Zhu et al.(2011)
sv_SOLEXA_5_FBgn0005561
0.712 0.712
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000381499 Paired box 98 222
ENSP00000410355 Paired box 74 198
ENSP00000481334 Paired box 98 222

Links

Other Paired box family TFs
Other Homo sapiens TFs

514 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
MDP0000183865 Malus domestica MDP0000183865 I 0.000
chr5.CM0571.20.nd Lotus japonicus chr5.CM0571.20.nd N 0.000
Lus10013592.g Linum usitatissimum Lus10013592.g N 0.000
Gorai.007G363800 Gossypium raimondii Gorai.007G363800 N 0.000
Gorai.002G234400 Gossypium raimondii Gorai.002G234400 N 0.000
gene18295-v1.0-hybrid Fragaria vesca gene18295-v1.0-hybrid N 0.000
evm.TU.supercontig_104.9 Carica papaya evm.TU.supercontig_104.9 N 0.000
Eucgr.A02570 Eucalyptus grandis Eucgr.A02570 N 0.000
Ciclev10012232m.g Citrus clementina Ciclev10012232m.g N 0.000
Carubv10014086m.g Capsella rubella Carubv10014086m.g N 0.000
Carubv10001713m.g Capsella rubella Carubv10001713m.g N 0.000
Cagra.2117s0012 Capsella grandiflora Cagra.2117s0012 N 0.000
Cagra.2108s0005 Capsella grandiflora Cagra.2108s0005 N 0.000
Lus10021259.g Linum usitatissimum Lus10021259.g N 0.000
MDP0000129029 Malus domestica MDP0000129029 N 0.000
chr1.CM0361.430.nc Lotus japonicus chr1.CM0361.430.nc N 0.000
PK26326.1 Cannabis sativa PK26326.1 N 0.000
Thhalv10014346m.g Eutrema salsugineum Thhalv10014346m.g N 0.000
SapurV1A.1209s0040 Salix purpurea SapurV1A.1209s0040 N 0.000
SapurV1A.0980s0030 Salix purpurea SapurV1A.0980s0030 N 0.000
SapurV1A.0258s0010 Salix purpurea SapurV1A.0258s0010 N 0.000
orange1.1g021081m.g Citrus sinensis orange1.1g021081m.g N 0.000
MDP0000948645 Malus domestica MDP0000948645 N 0.000
MDP0000785523 Malus domestica MDP0000785523 N 0.000
MDP0000588222 Malus domestica MDP0000588222 N 0.000
MDP0000375005 Malus domestica MDP0000375005 N 0.000
Bostr.13129s0320 Boechera stricta Bostr.13129s0320 N 0.000
Aquca_009_00676 Aquilegia coerulea Aquca_009_00676 N 0.000
POPTR_0006s21640 Populus trichocarpa POPTR_0006s21640 N 0.000
PGSC0003DMG400021365 Solanum tuberosum PGSC0003DMG400021365 N 0.000
MTR_7g106450 Medicago truncatula MTR_7g106450 N 0.000
MTR_1g056530 Medicago truncatula MTR_1g056530 N 0.000
GSMUA_Achr3G29730_001 Musa acuminata GSMUA_Achr3G29730_001 N 0.000
GLYMA19G38800 Glycine max GLYMA19G38800 N 0.000
GLYMA10G10240 Glycine max GLYMA10G10240 N 0.000
GLYMA03G36140 Glycine max GLYMA03G36140 N 0.000
GLYMA02G35190 Glycine max GLYMA02G35190 N 0.000
Bo9g176100 Brassica oleracea Bo9g176100 N 0.000
Bo3g060160 Brassica oleracea Bo3g060160 N 0.000
POPTR_0016s06860 Populus trichocarpa POPTR_0016s06860 N 0.000
PRUPE_ppa017366mg Prunus persica PRUPE_ppa017366mg N 0.000
NF-YA10 Arabidopsis lyrata scaffold_600636.1 N 0.000
mgf025421m Mimulus guttatus mgf025421m N 0.000
Cucsa.241980 Cucumis sativus Cucsa.241980 N 0.000
cassava24247.valid.m1 Manihot esculenta cassava24247.valid.m1 N 0.000
29333.m001059 Ricinus communis 29333.m001059 N 0.000
Pm026038 Prunus mume Pm026038 N 0.000
Cla017884 Citrullus lanatus Cla017884 N 0.000
Ca_14455 Cicer arietinum Ca_14455 N 0.000
Ca_00866 Cicer arietinum Ca_00866 N 0.000
VIT_08s0032g01190 Vitis vinifera VIT_08s0032g01190 N 0.000
TCM_022984 Theobroma cacao TCM_022984 N 0.000
Solyc01g006930.2 Solanum lycopersicum Solyc01g006930.2 N 0.000
NFYA10 Arabidopsis thaliana AT5G06510 N 0.000