Prox1 (Mus musculus)
Prospero

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF05044 (HPD) IPR007738 ENSMUSG00000010175 T316501_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; circulatory system development; and positive regulation of cell differentiation. Acts upstream of or within several processes, including animal organ development; epithelial cell differentiation; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and eye. Used to study dilated cardiomyopathy and obesity. Orthologous to human PROX1 (prospero homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
PROX1
M03445_2.00 		Homo sapiens
BAAGRCGTCTTV
BAAGACGYCTTV		 SELEX
Jolma et al.(2013)
PROX1_1 		1.000 1.000
PROX1
M05691_2.00 		Homo sapiens
BAMGRCGTCDTV
BAHGACGYCKTV		 SELEX
Yin et al.(2017)
PROX1_eDBD_HT-SELEX 		1.000 1.000
PROX1
M05692_2.00 		Homo sapiens
BAAGRYGTCTTV
BAAGACRYCTTV		 SELEX
Yin et al.(2017)
PROX1_eDBD_Methyl-HT-SELEX 		1.000 1.000
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000010319 Prospero 579 732
ENSMUSP00000135066 Prospero 579 732
ENSMUSP00000135703 Prospero 579 732

Links

Other Prospero family TFs
Other Mus musculus TFs

Invalid Input OrderBy

152 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action