CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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NFKB2
(
Homo sapiens
)
Rel
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00554 (RHD_DNA_bind)
IPR011539
ENSG00000077150
T317167_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
NFKB2
M03446_2.00
Homo sapiens
NGGGGAWTCCCCB
VGGGGAWTCCCCN
SELEX
Jolma et al.(2013)
NFKB2_1
(Direct)
(Direct)
NFKB2
M05699_2.00
Homo sapiens
HGGKRNWTCCCCN
NGGGGAWNYMCCD
SELEX
Yin et al.(2017)
NFKB2_eDBD_HT-SELEX
(Direct)
(Direct)
NFKB2
M05700_2.00
Homo sapiens
HGGKRNWTYCCCN
NGGGRAWNYMCCD
SELEX
Yin et al.(2017)
NFKB2_eDBD_Methyl-HT-SELEX
(Direct)
(Direct)
NFKB2
M09344_2.00
Homo sapiens
GGGRHTTYCCC
GGGRAADYCCC
Misc
Kulakovskiy et al.(2013)
NFKB2_HUMAN.H11MO.0.B
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Nfkb2
M09356_2.00
Mus musculus
GGGRHTTYCCC
GGGRAADYCCC
Misc
Kulakovskiy et al.(2013)
NFKB2_MOUSE.H11MO.0.C
1.000
1.000
NFKB1
M03448_2.00
Homo sapiens
MGGGGAWTCCCCT
AGGGGAWTCCCCK
SELEX
Jolma et al.(2013)
NFKB1_1
0.897
0.897
NFKB1
M05887_2.00
Homo sapiens
NGGKRNTYYCCCN
NGGGRRANYMCCN
SMiLE-seq
Isakova et al.(2017)
NFKB1
0.897
0.897
NFKB1
M09348_2.00
Homo sapiens
HYTTCCCY
RGGGAARD
Misc
Kulakovskiy et al.(2013)
NFKB1_HUMAN.H11MO.0.A
0.897
0.897
Nfkb1
M09358_2.00
Mus musculus
GGGRNTTYCCC
GGGRAANYCCC
Misc
Kulakovskiy et al.(2013)
NFKB1_MOUSE.H11MO.0.A
0.897
0.897
NFKB1
M11228_2.00
Homo sapiens
GGGGATYCCC
GGGRATCCCC
Transfac
Matys et al.(2006)
V$NFKAPPAB50_01
0.897
0.897
NFKB1
M11229_2.00
Homo sapiens
NGGGAHTYYCCM
KGGRRADTCCCN
Transfac
Matys et al.(2006)
V$NFKB_C
0.897
0.897
NFKB1
M11230_2.00
Homo sapiens
DKGGGAMTTYCCNN
NNGGRAAKTCCCMH
Transfac
Matys et al.(2006)
V$NFKB_Q6
0.897
0.897
NFKB1
M11231_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P50_Q6
0.897
0.897
For this family, TFs with SR scores >
0.700
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000189444
Rel
40
220
LVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGICAVSVGPKDMTAQFNNLGVLHVTKKNMMGTMIQKLQRQRLRSRPQGLTEAEQRELEQEAKELKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDS
ENSP00000358983
Rel
40
220
LVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGICAVSVGPKDMTAQFNNLGVLHVTKKNMMGTMIQKLQRQRLRSRPQGLTEAEQRELEQEAKELKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDS
ENSP00000410256
Rel
40
220
LVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGICAVSVGPKDMTAQFNNLGVLHVTKKNMMGTMIQKLQRQRLRSRPQGLTEAEQRELEQEAKELKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDS
ENSP00000471586
Rel
40
68
LVIVEQPKQRGFRFRYGCEGPSHGGLPGA
ENSP00000480211
Rel
40
220
LVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGICAVSVGPKDMTAQFNNLGVLHVTKKNMMGTMIQKLQRQRLRSRPQGLTEAEQRELEQEAKELKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDS
Links
Other
Rel
family TFs
Other
Homo sapiens
TFs
101 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy