NFKB1 (Homo sapiens)
Rel

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00554 (RHD_DNA_bind) IPR011539 ENSG00000109320 T317172_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Aug 2020]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
NFKB1
M03448_2.00		 Homo sapiens
MGGGGAWTCCCCT
AGGGGAWTCCCCK		 SELEX
Jolma et al.(2013)
NFKB1_1		 (Direct) (Direct)
NFKB1
M05887_2.00		 Homo sapiens
NGGKRNTYYCCCN
NGGGRRANYMCCN		 SMiLE-seq
Isakova et al.(2017)
NFKB1		 (Direct) (Direct)
NFKB1
M09348_2.00		 Homo sapiens
HYTTCCCY
RGGGAARD		 Misc
Kulakovskiy et al.(2013)
NFKB1_HUMAN.H11MO.0.A		 (Direct) (Direct)
NFKB1
M11228_2.00		 Homo sapiens
GGGGATYCCC
GGGRATCCCC		 Transfac
Matys et al.(2006)
V$NFKAPPAB50_01		 (Direct) (Direct)
NFKB1
M11229_2.00		 Homo sapiens
NGGGAHTYYCCM
KGGRRADTCCCN		 Transfac
Matys et al.(2006)
V$NFKB_C		 (Direct) (Direct)
NFKB1
M11230_2.00		 Homo sapiens
DKGGGAMTTYCCNN
NNGGRAAKTCCCMH		 Transfac
Matys et al.(2006)
V$NFKB_Q6		 (Direct) (Direct)
NFKB1
M11231_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$P50_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Nfkb1
M09358_2.00 		Mus musculus
GGGRNTTYCCC
GGGRAANYCCC		 Misc
Kulakovskiy et al.(2013)
NFKB1_MOUSE.H11MO.0.A 		1.000 1.000
NFKB2
M03446_2.00 		Homo sapiens
NGGGGAWTCCCCB
VGGGGAWTCCCCN		 SELEX
Jolma et al.(2013)
NFKB2_1 		0.870 0.870
NFKB2
M05699_2.00 		Homo sapiens
HGGKRNWTCCCCN
NGGGGAWNYMCCD		 SELEX
Yin et al.(2017)
NFKB2_eDBD_HT-SELEX 		0.870 0.870
NFKB2
M09344_2.00 		Homo sapiens
GGGRHTTYCCC
GGGRAADYCCC		 Misc
Kulakovskiy et al.(2013)
NFKB2_HUMAN.H11MO.0.B 		0.870 0.870
Nfkb2
M09356_2.00 		Mus musculus
GGGRHTTYCCC
GGGRAADYCCC		 Misc
Kulakovskiy et al.(2013)
NFKB2_MOUSE.H11MO.0.C 		0.870 0.870
NFKB2
M05700_2.00 		Homo sapiens
HGGKRNWTYCCCN
NGGGRAWNYMCCD		 SELEX
Yin et al.(2017)
NFKB2_eDBD_Methyl-HT-SELEX 		0.700 0.700
RELB
M08161_2.00 		Homo sapiens
NNATTCCCCNN
NNGGGGAATNN		 ChIP-seq
Mathelier et al.(2014)
MA1117.1 		0.739 0.739
RELB
M09347_2.00 		Homo sapiens
VGGGRMTTTSMH
DKSAAAKYCCCB		 Misc
Kulakovskiy et al.(2013)
RELB_HUMAN.H11MO.0.C 		0.739 0.739
Relb
M09352_2.00 		Mus musculus
VGGGRMTTTSMH
DKSAAAKYCCCB		 Misc
Kulakovskiy et al.(2013)
RELB_MOUSE.H11MO.0.C 		0.739 0.739
RELB
M11227_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RELBP50_Q3 		0.739 0.739
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000226574 Rel 45 243
ENSP00000378297 Rel 44 242
ENSP00000420904 Rel 52 74
ENSP00000423877 Rel 45 144
ENSP00000424790 Rel 44 242
ENSP00000424815 Rel 1 36
ENSP00000426147 Rel 53 186
ENSP00000469340 Rel 6 62

Links

Other Rel family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

79 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action