RELA (Homo sapiens)
Rel

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00554 (RHD_DNA_bind) IPR011539 ENSG00000173039 T317175_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
RELA
M02711_2.00
Homo sapiens
SGGRVTTTCC

GGAAABYCCS
SELEX
Mathelier et al.(2014)
MA0107.1
(Direct) (Direct)
RELA
M07999_2.00
Homo sapiens
DGGGRMTTTCCMVN

NBKGGAAAKYCCCH
ChIP-seq
Gerstein et al.(2012)
GM10847_NFKB_Stanford
(Direct) (Direct)
RELA
M08000_2.00
Homo sapiens
NDGGGRMWTTCCHN

NDGGAAWKYCCCHN
ChIP-seq
Gerstein et al.(2012)
GM12878_NFKB_Stanford
(Direct) (Direct)
RELA
M08001_2.00
Homo sapiens
NDGGGRMTTTCCMVN

NBKGGAAAKYCCCHN
ChIP-seq
Gerstein et al.(2012)
GM12891_NFKB_Stanford
(Direct) (Direct)
RELA
M08002_2.00
Homo sapiens
DGGGRHTTTCCMVNN

NNBKGGAAADYCCCH
ChIP-seq
Gerstein et al.(2012)
GM12892_NFKB_Stanford
(Direct) (Direct)
RELA
M08003_2.00
Homo sapiens
DGGGRVTTTCCHVN

NBDGGAAABYCCCH
ChIP-seq
Gerstein et al.(2012)
GM15510_NFKB_Stanford
(Direct) (Direct)
RELA
M08004_2.00
Homo sapiens
NDGGGRMTTTCCMNN

NNKGGAAAKYCCCHN
ChIP-seq
Gerstein et al.(2012)
GM18505_NFKB_Stanford
(Direct) (Direct)
RELA
M08005_2.00
Homo sapiens
NDGGGRHTTTCCMVN

NBKGGAAADYCCCHN
ChIP-seq
Gerstein et al.(2012)
GM18526_NFKB_Stanford
(Direct) (Direct)
RELA
M08006_2.00
Homo sapiens
GGGRVTTTCCM

KGGAAABYCCC
ChIP-seq
Gerstein et al.(2012)
GM18951_NFKB_Stanford
(Direct) (Direct)
RELA
M08007_2.00
Homo sapiens
DGGGRMTTTCCMV

BKGGAAAKYCCCH
ChIP-seq
Gerstein et al.(2012)
GM19099_NFKB_Stanford
(Direct) (Direct)
RELA
M08008_2.00
Homo sapiens
DGGGRMTTTCCMNNN

NNNKGGAAAKYCCCH
ChIP-seq
Gerstein et al.(2012)
GM19193_NFKB_Stanford
(Direct) (Direct)
RELA
M09351_2.00
Homo sapiens
NWGGGRHWTTCCMV

BKGGAAWDYCCCWN
Misc
Kulakovskiy et al.(2013)
TF65_HUMAN.H11MO.0.A
(Direct) (Direct)
RELA
M09626_2.00
Homo sapiens
DGGGRVWTTCCM

KGGAAWBYCCCH
Misc
Heinz et al.(2010)
GM12787-p65_GSE19485
(Direct) (Direct)
RELA
M11237_2.00
Homo sapiens
BGGRVTTTCC

GGAAABYCCV
Transfac
Matys et al.(2006)
V$NFKAPPAB65_01
(Direct) (Direct)
RELA
M11238_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$RELA_02
(Direct) (Direct)
RELA
M11239_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$RELA_03
(Direct) (Direct)
RELA
M11240_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$RELA_04
(Direct) (Direct)
RELA
M11241_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$RELA_05
(Direct) (Direct)
RELA
M11242_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$RELA_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Rela
M08039_2.00
Mus musculus
DGGRVTTTCCM

KGGAAABYCCH
ChIP-seq
Chen et al.(2011)
SRP001843_p65_Input_LPSstim
0.952 0.952
Rela
M08038_2.00
Mus musculus
HHYYYCYYNYHYYYNHYYYYCYWNNSYTBY

RVARSNNWRGRRRRDNRRRDRNRRGRRRDD
ChIP-seq
Chen et al.(2011)
SRP001843_p65_Input
0.952 0.952
Rela
M09355_2.00
Mus musculus
KGGRVTTYCCM

KGGRAABYCCM
Misc
Kulakovskiy et al.(2013)
TF65_MOUSE.H11MO.0.A
0.952 0.952
Rel
M09353_2.00
Mus musculus
TGKVMTTYCCCHDBH

DVHDGGGRAAKBMCA
Misc
Kulakovskiy et al.(2013)
REL_MOUSE.H11MO.0.A
0.828 0.828
REL
M02710_2.00
Homo sapiens
BGGRNWTTCC

GGAAWNYCCV
SELEX
Mathelier et al.(2014)
MA0101.1
0.793 0.793
REL
M09350_2.00
Homo sapiens
TGKVMTTYCCCHDBH

DVHDGGGRAAKBMCA
Misc
Kulakovskiy et al.(2013)
REL_HUMAN.H11MO.0.B
0.793 0.793
REL
M11235_2.00
Homo sapiens
BGGRNWTTCC

GGAAWNYCCV
Transfac
Matys et al.(2006)
V$CREL_01
0.702 0.702
REL
M11236_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CREL_Q6
0.750 0.750
Dif
M03953_2.00
Drosophila melanogaster
BGGGWTTTYCCCN

NGGGRAAAWCCCV
SELEX
Nitta et al.(2015)
Dif_1
0.724 0.724
Dif
M03954_2.00
Drosophila melanogaster
NGGGDWTTHCCCN

NGGGDAAWHCCCN
SELEX
Nitta et al.(2015)
Dif_2
0.724 0.724
Dif
M03955_2.00
Drosophila melanogaster
BGGGAWWTCCCV

BGGGAWWTCCCV
SELEX
Nitta et al.(2015)
Dif_3
0.724 0.724
Dif
M03956_2.00
Drosophila melanogaster
GGRAAWNNNNNNNWTTYCC

GGRAAWNNNNNNNWTTYCC
SELEX
Nitta et al.(2015)
Dif_4
0.724 0.724
dl
M02712_2.00
Drosophila melanogaster
SGGGKTTTTYCV

BGRAAAAMCCCS
SELEX
Mathelier et al.(2014)
MA0022.1
0.724 0.724
dl
M02713_2.00
Drosophila melanogaster
GGGGWWTTCC

GGAAWWCCCC
SELEX
Mathelier et al.(2014)
MA0023.1
0.724 0.724
RELB
M08161_2.00
Homo sapiens
NNATTCCCCNN

NNGGGGAATNN
ChIP-seq
Mathelier et al.(2014)
MA1117.1
0.724 0.724
RELB
M09347_2.00
Homo sapiens
VGGGRMTTTSMH

DKSAAAKYCCCB
Misc
Kulakovskiy et al.(2013)
RELB_HUMAN.H11MO.0.C
0.724 0.724
Relb
M09352_2.00
Mus musculus
VGGGRMTTTSMH

DKSAAAKYCCCB
Misc
Kulakovskiy et al.(2013)
RELB_MOUSE.H11MO.0.C
0.724 0.724
dl
M09691_2.00
Drosophila melanogaster
BRGRWTTYCCM

KGGRAAWYCYV
Misc
Kulakovskiy et al.(2009)
dl
0.724 0.724
dl
M11243_2.00
Drosophila melanogaster
GGGTTTTTCCV

BGGAAAAACCC
Transfac
Matys et al.(2006)
I$DL_01
0.724 0.724
dl
M11244_2.00
Drosophila melanogaster
BRDTTTTCYSD

HSRGAAAAHYV
Transfac
Matys et al.(2006)
I$DL_02
0.724 0.724
RELB
M11227_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$RELBP50_Q3
0.724 0.724
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000311508 Rel 21 183
ENSP00000384273 Rel 21 186
ENSP00000431153 Rel 21 151
ENSP00000432537 Rel 21 186
ENSP00000432922 Rel 21 69
ENSP00000433144 Rel 21 64
ENSP00000433526 Rel 21 197
ENSP00000433616 Rel 1 29
ENSP00000434098 Rel 1 95
ENSP00000434372 Rel 12 177
ENSP00000434745 Rel 21 67
ENSP00000435290 Rel 21 186
ENSP00000435531 Rel 1 89
ENSP00000436545 Rel 1 155
ENSP00000437137 Rel 21 115
ENSP00000479572 Rel 21 186
ENSP00000483705 Rel 21 186

Links

Other Rel family TFs
Other Homo sapiens TFs

114 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
RELA Loxodonta africana ENSLAFG00000021967 I 1.000
RELA Macaca mulatta ENSMMUG00000007418 I 1.000
RELA Gorilla gorilla ENSGGOG00000011810 I 1.000
rela Xenopus tropicalis XB-GENE-946506 I 1.000
RELA Felis catus ENSFCAG00000005696 I 1.000
ENSNLEG00000005769 Nomascus leucogenys ENSNLEG00000005769 I 1.000
ENSOPRG00000010827 Ochotona princeps ENSOPRG00000010827 I 1.000
RELA Tupaia belangeri ENSTBEG00000004751 I 1.000
RELA Tursiops truncatus ENSTTRG00000002311 I 1.000
RELA Sorex araneus ENSSARG00000003535 I 1.000
ENSPPYG00000003053 Pongo abelii ENSPPYG00000003053 I 1.000
ENSP00000384273 Macaca fascicularis ENSP00000384273 I 1.000
ENSPANG00000013650 Papio anubis ENSPANG00000013650 I 1.000
ENSCSAG00000007981 Chlorocebus sabaeus ENSCSAG00000007981 I 1.000
ENSMPUG00000011637 Mustela putorius furo ENSMPUG00000011637 I 1.000
ENSCHOG00000004207 Choloepus hoffmanni ENSCHOG00000004207 I 1.000
RELA Cavia porcellus ENSCPOG00000020593 I 1.000
RELA Microcebus murinus ENSMICG00000008872 I 0.994
RELA Pan troglodytes ENSPTRG00000003889 I 0.994
Rela Rattus norvegicus ENSRNOG00000030888 I 0.994
RELA Otolemur garnettii ENSOGAG00000014117 I 0.994
Myotis_brandtii_Rela_10030730 Myotis brandtii Myotis_brandtii_Rela_10030730 I 0.989
RELA Myotis lucifugus ENSMLUG00000008727 I 0.989
ENSSTOG00000027336 Ictidomys tridecemlineatus ENSSTOG00000027336 I 0.989
ENSP00000384273-D1 Bos grunniens ENSP00000384273-D1 I 0.988
RELA Canis familiaris ENSCAFG00000013334 I 0.988
RELA Equus caballus ENSECAG00000013763 I 0.988
RELA Callithrix jacchus ENSCJAG00000002037 I 0.988
RELA Sus scrofa ENSSSCG00000012981 I 0.988
ENSAMEG00000017369 Ailuropoda melanoleuca ENSAMEG00000017369 I 0.988
RELA Pteropus vampyrus ENSPVAG00000009983 I 0.988
RELA Bos taurus ENSBTAG00000013895 I 0.988
RELA Dasypus novemcinctus ENSDNOG00000039743 I 0.982
rela.L Xenopus laevis XB-GENE-946512 I 0.966
Rela Mus musculus ENSMUSG00000024927 D 0.958
ENSOARG00000017426 Ovis aries ENSOARG00000017426 I 0.958
ENSPSIG00000002944 Pelodiscus sinensis ENSPSIG00000002944 I 0.955
RELA Monodelphis domestica ENSMODG00000009603 I 0.904
Cmyd_10013204 Chelonia mydas Cmyd_10013204 I 0.899
rela Takifugu rubripes ENSTRUG00000008758 N 0.897
ENSTNIG00000003566 Tetraodon nigroviridis ENSTNIG00000003566 N 0.897
ENSTNIG00000002231 Tetraodon nigroviridis ENSTNIG00000002231 N 0.897
ENSMEUG00000005955 Macropus eugenii ENSMEUG00000005955 I 0.895
Ogr00666 Ophisaurus gracilis Ogr00666 I 0.886
ENSOANG00000004820 Ornithorhynchus anatinus ENSOANG00000004820 I 0.880
ENSGMOG00000016783 Gadus morhua ENSGMOG00000016783 N 0.862
ENSXMAG00000011436 Xiphophorus maculatus ENSXMAG00000011436 N 0.841
REL Gallus gallus ENSGALG00000007845 I 0.828
REL Meleagris gallopavo ENSMGAG00000001721 I 0.828
rel Oryzias latipes ENSORLG00000001586 I 0.828
Rel Mus musculus ENSMUSG00000020275 D 0.828
ENSSSCG00000027479 Sus scrofa ENSSSCG00000027479 I 0.821
ENSPSIG00000013860 Pelodiscus sinensis ENSPSIG00000013860 I 0.818
ENSAMXG00000021617 Astyanax mexicanus ENSAMXG00000021617 N 0.818
Rel Rattus norvegicus ENSRNOG00000054437 I 0.795
Cmyd_10008594 Chelonia mydas Cmyd_10008594 I 0.795
REL Felis catus ENSFCAG00000008018 I 0.793
REL Tursiops truncatus ENSTTRG00000013347 N 0.793
ENSFALG00000011066 Ficedula albicollis ENSFALG00000011066 I 0.793
REL Canis familiaris ENSCAFG00000002981 I 0.793
Brh_R000963 Buceros rhinoceros Brh_R000963 I 0.793
REL Pteropus vampyrus ENSPVAG00000000364 I 0.793
ENSAMEG00000018236 Ailuropoda melanoleuca ENSAMEG00000018236 I 0.793
Ogr08766 Ophisaurus gracilis Ogr08766 I 0.793
REL Gorilla gorilla ENSGGOG00000024826 I 0.773
CGI_10021567 Crassostrea gigas CGI_10021567 N 0.773
ENSOARG00000001457 Ovis aries ENSOARG00000001457 I 0.773
ENSGMOG00000018800 Gadus morhua ENSGMOG00000018800 I 0.773
HelroG69490 Helobdella robusta HelroG69490 N 0.759
Aan_R015916 Calypte anna Aan_R015916 I 0.759
ENSTNIG00000017107 Tetraodon nigroviridis ENSTNIG00000017107 N 0.759
rela Danio rerio ENSDARG00000098696 N 0.753
REL Taeniopygia guttata ENSTGUG00000006743 I 0.750
REL Monodelphis domestica ENSMODG00000002172 I 0.750
REL Callithrix jacchus ENSCJAG00000008975 I 0.750
ENSAMXG00000004647 Astyanax mexicanus ENSAMXG00000004647 I 0.750
REL Otolemur garnettii ENSOGAG00000013722 I 0.750
ENSAPLG00000006795 Anas platyrhynchos ENSAPLG00000006795 I 0.750
Pvit_10466 Pogona vitticeps Pvit_10466 I 0.737
ENSXMAG00000007379 Xiphophorus maculatus ENSXMAG00000007379 I 0.727
CapteG220294 Capitella teleta CapteG220294 N 0.727
REL Equus caballus ENSECAG00000003277 I 0.727
Pvit_04537 Pogona vitticeps Pvit_04537 I 0.727
RELB Anolis carolinensis ENSACAG00000004079 I 0.727
REL Microcebus murinus ENSMICG00000010062 I 0.727
ENSPFOG00000013038 Poecilia formosa ENSPFOG00000013038 I 0.727
GK10525 Drosophila willistoni FBgn0212540 I 0.724
dl Drosophila melanogaster FBgn0260632 D 0.724
LCUP010246 Lucilia cuprina LCUP010246 I 0.724
GM17128 Drosophila sechellia FBgn0172039 I 0.724
GB44031 Apis mellifera GB44031 I 0.724
ENSOPRG00000014981 Ochotona princeps ENSOPRG00000014981 I 0.724
ENSDNOG00000032456 Dasypus novemcinctus ENSDNOG00000032456 I 0.724
RELB Pan troglodytes ENSPTRG00000011133 I 0.724
GL18753 Drosophila persimilis FBgn0156354 I 0.724
Relb Dipodomys ordii ENSDORG00000003448 I 0.724
ENSGMOG00000014662 Gadus morhua ENSGMOG00000014662 N 0.724
RELB Myotis lucifugus ENSMLUG00000006593 I 0.724
RELB Homo sapiens ENSG00000104856 D 0.724
ENSCSAG00000003233 Chlorocebus sabaeus ENSCSAG00000003233 I 0.724
GF15103 Drosophila ananassae FBgn0092128 I 0.724
GG21746 Drosophila erecta FBgn0113924 I 0.724
GA19765 Drosophila pseudoobscura FBgn0079761 I 0.724
dl Drosophila simulans FBgn0067500 I 0.724
dl Drosophila yakuba FBgn0067431 I 0.724
RELB Gorilla gorilla ENSGGOG00000003380 I 0.724
Tal_R005550 Tyto alba Tal_R005550 I 0.721
ENSSHAG00000002714 Sarcophilus harrisii ENSSHAG00000002714 I 0.716
ENSORLG00000011104 Oryzias latipes ENSORLG00000011104 N 0.715
ENSPFOG00000009881 Poecilia formosa ENSPFOG00000009881 N 0.715
RELB Tupaia belangeri ENSTBEG00000001763 I 0.714
ENSONIG00000001545 Oreochromis niloticus ENSONIG00000001545 N 0.708
BGLB003257 Biomphalaria glabrata BGLB003257 N 0.705