Relb (Mus musculus)
Rel

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00554 (RHD_DNA_bind) IPR011539 ENSMUSG00000002983 T317309_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in circadian regulation of gene expression; negative regulation of transcription, DNA-templated; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including NIK/NF-kappaB signaling; antigen processing and presentation; and mononuclear cell differentiation. Located in cytosol and nucleus. Is expressed in axial skeleton; eye; heart; and ureter. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in breast cancer and immunodeficiency 53. Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Relb
M09352_2.00		 Mus musculus
VGGGRMTTTSMH
DKSAAAKYCCCB		 Misc
Kulakovskiy et al.(2013)
RELB_MOUSE.H11MO.0.C		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
RELB
M08161_2.00 		Homo sapiens
NNATTCCCCNN
NNGGGGAATNN		 ChIP-seq
Mathelier et al.(2014)
MA1117.1 		0.970 0.970
RELB
M09347_2.00 		Homo sapiens
VGGGRMTTTSMH
DKSAAAKYCCCB		 Misc
Kulakovskiy et al.(2013)
RELB_HUMAN.H11MO.0.C 		0.970 0.970
RELB
M11227_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RELBP50_Q3 		0.970 0.970
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000050166 Rel 102 270
ENSMUSP00000092355 Rel 105 273
ENSMUSP00000096350 Rel 105 273

Links

Other Rel family TFs
Other Mus musculus TFs

36 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
Relb Rattus norvegicus ENSRNOG00000033235 I 1.000
RELB Felis catus ENSFCAG00000025715 I 0.976
ENSPPYG00000010103 Pongo abelii ENSPPYG00000010103 I 0.976
RELB Macaca mulatta ENSMMUG00000014153 I 0.976
ENSOARG00000009545 Ovis aries ENSOARG00000009545 I 0.976
RELB Canis familiaris ENSCAFG00000004597 I 0.976
ENSAMEG00000012673 Ailuropoda melanoleuca ENSAMEG00000012673 I 0.976
RELB Callithrix jacchus ENSCJAG00000012991 I 0.976
ENSPANG00000007219 Papio anubis ENSPANG00000007219 I 0.976
RELB Bos taurus ENSBTAG00000038428 I 0.976
RELB Pan troglodytes ENSPTRG00000011133 I 0.970
RELB Microcebus murinus ENSMICG00000006991 I 0.970
RELB Homo sapiens ENSG00000104856 D 0.970
RELB Cavia porcellus ENSCPOG00000010273 I 0.970
RELB Gorilla gorilla ENSGGOG00000003380 I 0.970
RELB Otolemur garnettii ENSOGAG00000012777 I 0.964
ENSOPRG00000014981 Ochotona princeps ENSOPRG00000014981 I 0.964
RELB Tursiops truncatus ENSTTRG00000015217 I 0.964
Relb Dipodomys ordii ENSDORG00000003448 I 0.964
RELB Myotis lucifugus ENSMLUG00000006593 I 0.958
RELB Pteropus vampyrus ENSPVAG00000015952 I 0.952
RELB Equus caballus ENSECAG00000020898 I 0.934
RELB Monodelphis domestica ENSMODG00000020855 I 0.922
RELB Procavia capensis ENSPCAG00000010787 I 0.916
ENSCSAG00000003233 Chlorocebus sabaeus ENSCSAG00000003233 I 0.910
ENSDNOG00000032456 Dasypus novemcinctus ENSDNOG00000032456 I 0.910
ENSSTOG00000009056 Ictidomys tridecemlineatus ENSSTOG00000009056 I 0.904
Alligator_sinensis_CCG000883.1 Alligator sinensis Alligator_sinensis_CCG000883.1 I 0.783
RELB Loxodonta africana ENSLAFG00000008071 I 0.777
ENSBTAP00000049624-D1 Bos grunniens ENSBTAP00000049624-D1 I 0.765
ENSPSIG00000012895 Pelodiscus sinensis ENSPSIG00000012895 I 0.765
Pvit_18473 Pogona vitticeps Pvit_18473 I 0.759
Ogr08766 Ophisaurus gracilis Ogr08766 I 0.753
RELB Anolis carolinensis ENSACAG00000004079 I 0.747
ENSP00000221452 Macaca fascicularis ENSP00000221452 I 0.729