TF Information

Relb *(Mus musculus)* Rel
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00554 (RHD_DNA_bind)	IPR011539	ENSMUSG00000002983	T317309_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in circadian regulation of gene expression; negative regulation of transcription, DNA-templated; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including NIK/NF-kappaB signaling; antigen processing and presentation; and mononuclear cell differentiation. Located in cytosol and nucleus. Is expressed in axial skeleton; eye; heart; and ureter. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in breast cancer and immunodeficiency 53. Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Relb M09352_2.00	Mus musculus	VGGGRMTTTSMH	DKSAAAKYCCCB	Misc Kulakovskiy et al.(2013) RELB_MOUSE.H11MO.0.C	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
RELB M08161_2.00	Homo sapiens	NNATTCCCCNN	NNGGGGAATNN	ChIP-seq Mathelier et al.(2014) MA1117.1	0.970	0.970
RELB M09347_2.00	Homo sapiens	VGGGRMTTTSMH	DKSAAAKYCCCB	Misc Kulakovskiy et al.(2013) RELB_HUMAN.H11MO.0.C	0.970	0.970
RELB M11227_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$RELBP50_Q3	0.970	0.970
For this family, TFs with SR scores > 0.700* will likely have a similar motif*

DNA Binding Domains

Protein ID	Domain	From	To	Sequence
ENSMUSP00000050166	Rel	102	270	LVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCTDGVCRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGHLHRMDPILSEPVYDK
ENSMUSP00000092355	Rel	105	273	LVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCTDGVCRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGHLHRMDPILSEPVYDK
ENSMUSP00000096350	Rel	105	273	LVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCTDGVCRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGHLHRMDPILSEPVYDK

Links
Other Rel family TFs
Other *Mus musculus* TFs

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36 Related TFs

Name	Species	Gene ID	Motif Evidence	SR Score	Action