Nfkb1 (Rattus norvegicus)
Rel

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00554 (RHD_DNA_bind) IPR011539 ENSRNOG00000023258 T317480_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables heat shock protein binding activity; identical protein binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and regulation of gene expression. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in cytosol; neuron projection; and nucleus. Part of protein-containing complex. Used to study fatty liver disease. Biomarker of alcoholic hepatitis; non-alcoholic steatohepatitis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
NFKB1
M03448_2.00 		Homo sapiens
MGGGGAWTCCCCT
AGGGGAWTCCCCK		 SELEX
Jolma et al.(2013)
NFKB1_1 		0.994 0.994
NFKB1
M05887_2.00 		Homo sapiens
NGGKRNTYYCCCN
NGGGRRANYMCCN		 SMiLE-seq
Isakova et al.(2017)
NFKB1 		0.994 0.994
NFKB1
M09348_2.00 		Homo sapiens
HYTTCCCY
RGGGAARD		 Misc
Kulakovskiy et al.(2013)
NFKB1_HUMAN.H11MO.0.A 		0.994 0.994
NFKB1
M11228_2.00 		Homo sapiens
GGGGATYCCC
GGGRATCCCC		 Transfac
Matys et al.(2006)
V$NFKAPPAB50_01 		0.994 0.994
NFKB1
M11229_2.00 		Homo sapiens
NGGGAHTYYCCM
KGGRRADTCCCN		 Transfac
Matys et al.(2006)
V$NFKB_C 		0.994 0.994
NFKB1
M11230_2.00 		Homo sapiens
DKGGGAMTTYCCNN
NNGGRAAKTCCCMH		 Transfac
Matys et al.(2006)
V$NFKB_Q6 		0.994 0.994
NFKB1
M11231_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$P50_Q6 		0.994 0.994
Nfkb1
M09358_2.00 		Mus musculus
GGGRNTTYCCC
GGGRAANYCCC		 Misc
Kulakovskiy et al.(2013)
NFKB1_MOUSE.H11MO.0.A 		0.988 0.988
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSRNOP00000028944 Rel 43 241

Links

Other Rel family TFs
Other Rattus norvegicus TFs

Invalid Input OrderBy

65 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action