Rela (Rattus norvegicus)
Rel

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00554 (RHD_DNA_bind) IPR011539 ENSRNOG00000030888 T317481_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of pri-miRNA transcription by RNA polymerase II; and response to cobalamin. Located in chromatin; cytosol; and nucleus. Part of protein-containing complex. Is active in synapse. Used to study Parkinsonism; encephalitis; fatty liver disease; and status epilepticus. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); colitis; end stage renal disease; and uveitis. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Rela
M08039_2.00 		Mus musculus
DGGRVTTTCCM
KGGAAABYCCH		 ChIP-seq
Chen et al.(2011)
SRP001843_p65_Input_LPSstim 		0.964 0.964
Rela
M08038_2.00 		Mus musculus
HHYYYCYYNYHYYYNHYYYYCYWNNSYTBY
RVARSNNWRGRRRRDNRRRDRNRRGRRRDD		 ChIP-seq
Chen et al.(2011)
SRP001843_p65_Input 		0.964 0.964
Rela
M09355_2.00 		Mus musculus
KGGRVTTYCCM
KGGRAABYCCM		 Misc
Kulakovskiy et al.(2013)
TF65_MOUSE.H11MO.0.A 		0.964 0.964
RELA
M02711_2.00 		Homo sapiens
SGGRVTTTCC
GGAAABYCCS		 SELEX
Mathelier et al.(2014)
MA0107.1 		0.946 0.946
RELA
M07999_2.00 		Homo sapiens
DGGGRMTTTCCMVN
NBKGGAAAKYCCCH		 ChIP-seq
Gerstein et al.(2012)
GM10847_NFKB_Stanford 		0.946 0.946
RELA
M08000_2.00 		Homo sapiens
NDGGGRMWTTCCHN
NDGGAAWKYCCCHN		 ChIP-seq
Gerstein et al.(2012)
GM12878_NFKB_Stanford 		0.946 0.946
RELA
M08001_2.00 		Homo sapiens
NDGGGRMTTTCCMVN
NBKGGAAAKYCCCHN		 ChIP-seq
Gerstein et al.(2012)
GM12891_NFKB_Stanford 		0.946 0.946
RELA
M08002_2.00 		Homo sapiens
DGGGRHTTTCCMVNN
NNBKGGAAADYCCCH		 ChIP-seq
Gerstein et al.(2012)
GM12892_NFKB_Stanford 		0.946 0.946
RELA
M08003_2.00 		Homo sapiens
DGGGRVTTTCCHVN
NBDGGAAABYCCCH		 ChIP-seq
Gerstein et al.(2012)
GM15510_NFKB_Stanford 		0.946 0.946
RELA
M08004_2.00 		Homo sapiens
NDGGGRMTTTCCMNN
NNKGGAAAKYCCCHN		 ChIP-seq
Gerstein et al.(2012)
GM18505_NFKB_Stanford 		0.946 0.946
RELA
M08005_2.00 		Homo sapiens
NDGGGRHTTTCCMVN
NBKGGAAADYCCCHN		 ChIP-seq
Gerstein et al.(2012)
GM18526_NFKB_Stanford 		0.946 0.946
RELA
M08006_2.00 		Homo sapiens
GGGRVTTTCCM
KGGAAABYCCC		 ChIP-seq
Gerstein et al.(2012)
GM18951_NFKB_Stanford 		0.946 0.946
RELA
M08007_2.00 		Homo sapiens
DGGGRMTTTCCMV
BKGGAAAKYCCCH		 ChIP-seq
Gerstein et al.(2012)
GM19099_NFKB_Stanford 		0.946 0.946
RELA
M08008_2.00 		Homo sapiens
DGGGRMTTTCCMNNN
NNNKGGAAAKYCCCH		 ChIP-seq
Gerstein et al.(2012)
GM19193_NFKB_Stanford 		0.946 0.946
RELA
M09351_2.00 		Homo sapiens
NWGGGRHWTTCCMV
BKGGAAWDYCCCWN		 Misc
Kulakovskiy et al.(2013)
TF65_HUMAN.H11MO.0.A 		0.946 0.946
RELA
M09626_2.00 		Homo sapiens
DGGGRVWTTCCM
KGGAAWBYCCCH		 Misc
Heinz et al.(2010)
GM12787-p65_GSE19485 		0.946 0.946
RELA
M11237_2.00 		Homo sapiens
BGGRVTTTCC
GGAAABYCCV		 Transfac
Matys et al.(2006)
V$NFKAPPAB65_01 		0.946 0.946
RELA
M11238_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RELA_02 		0.946 0.946
RELA
M11239_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RELA_03 		0.946 0.946
RELA
M11240_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RELA_04 		0.946 0.946
RELA
M11241_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RELA_05 		0.946 0.946
RELA
M11242_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RELA_Q6 		0.946 0.946
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSRNOP00000044552 Rel 21 186

Links

Other Rel family TFs
Other Rattus norvegicus TFs

41 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSCHOG00000004207 Choloepus hoffmanni ENSCHOG00000004207 I 1.000
RELA Tupaia belangeri ENSTBEG00000004751 I 1.000
RELA Homo sapiens ENSG00000173039 D 0.994
RELA Gorilla gorilla ENSGGOG00000011810 I 0.994
RELA Loxodonta africana ENSLAFG00000021967 I 0.994
RELA Bos taurus ENSBTAG00000013895 I 0.988
RELA Macaca mulatta ENSMMUG00000007418 I 0.988
ENSPANG00000013650 Papio anubis ENSPANG00000013650 I 0.988
ENSP00000384273 Macaca fascicularis ENSP00000384273 I 0.988
RELA Pteropus vampyrus ENSPVAG00000009983 I 0.988
ENSAMEG00000017369 Ailuropoda melanoleuca ENSAMEG00000017369 I 0.988
ENSNLEG00000005769 Nomascus leucogenys ENSNLEG00000005769 I 0.988
RELA Microcebus murinus ENSMICG00000008872 I 0.988
RELA Pan troglodytes ENSPTRG00000003889 I 0.988
ENSPPYG00000003053 Pongo abelii ENSPPYG00000003053 I 0.988
ENSCSAG00000007981 Chlorocebus sabaeus ENSCSAG00000007981 I 0.988
RELA Equus caballus ENSECAG00000013763 I 0.988
RELA Felis catus ENSFCAG00000005696 I 0.988
RELA Canis familiaris ENSCAFG00000013334 I 0.988
RELA Callithrix jacchus ENSCJAG00000002037 I 0.988
ENSP00000384273-D1 Bos grunniens ENSP00000384273-D1 I 0.988
ENSSTOG00000027336 Ictidomys tridecemlineatus ENSSTOG00000027336 I 0.982
RELA Sus scrofa ENSSSCG00000012981 I 0.982
RELA Cavia porcellus ENSCPOG00000020593 I 0.982
RELA Otolemur garnettii ENSOGAG00000014117 I 0.982
RELA Myotis lucifugus ENSMLUG00000008727 I 0.976
Myotis_brandtii_Rela_10030730 Myotis brandtii Myotis_brandtii_Rela_10030730 I 0.976
RELA Tursiops truncatus ENSTTRG00000002311 I 0.976
RELA Dasypus novemcinctus ENSDNOG00000039743 I 0.976
Rela Mus musculus ENSMUSG00000024927 D 0.964
ENSOARG00000017426 Ovis aries ENSOARG00000017426 I 0.958
RELA Sorex araneus ENSSARG00000003535 I 0.952
ENSMPUG00000011637 Mustela putorius furo ENSMPUG00000011637 I 0.922
RELA Monodelphis domestica ENSMODG00000009603 I 0.898
ENSPSIG00000002944 Pelodiscus sinensis ENSPSIG00000002944 I 0.795
Cmyd_10013204 Chelonia mydas Cmyd_10013204 I 0.783
rela.L Xenopus laevis XB-GENE-946512 I 0.759
rela Xenopus tropicalis XB-GENE-946506 I 0.759
Ogr00666 Ophisaurus gracilis Ogr00666 I 0.753
Pvit_10466 Pogona vitticeps Pvit_10466 I 0.731
ENSOPRG00000010827 Ochotona princeps ENSOPRG00000010827 I 0.729