Rel (Drosophila melanogaster)
Rel

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00554 (RHD_DNA_bind) IPR011539 FBgn0014018 T317602_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to other organism; neuron development; and positive regulation of cellular biosynthetic process. Located in cytosol; euchromatin; and nucleus. Is expressed in several structures, including Malpighian tubule; blastoderm embryo; extended germ band embryo; germline cell; and gut section. Used to study neurodegenerative disease and opportunistic bacterial infectious disease. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to several human genes including NFKB2 (nuclear factor kappa B subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Rel
M03957_2.00		 Drosophila melanogaster
NGGGGRTTCCCCB
VGGGGAAYCCCCN		 SELEX
Nitta et al.(2015)
Rel_1		 (Direct) (Direct)
Rel
M03958_2.00		 Drosophila melanogaster
GGGGGTTCCCCB
VGGGGAACCCCC		 SELEX
Nitta et al.(2015)
Rel_2		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0088375 Rel 152 335
FBpp0088971 Rel 152 335
FBpp0088972 Rel 40 223
FBpp0088973 Rel 152 335

Links

Other Rel family TFs
Other Drosophila melanogaster TFs

Invalid Input OrderBy

14 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action