ENSP00000189444 (Macaca fascicularis)
Rel

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00554 (RHD_DNA_bind) IPR011539 ENSP00000189444 T317769_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
NFKB2
M03446_2.00 		Homo sapiens
NGGGGAWTCCCCB
VGGGGAWTCCCCN		 SELEX
Jolma et al.(2013)
NFKB2_1 		0.988 0.988
NFKB2
M05699_2.00 		Homo sapiens
HGGKRNWTCCCCN
NGGGGAWNYMCCD		 SELEX
Yin et al.(2017)
NFKB2_eDBD_HT-SELEX 		0.988 0.988
NFKB2
M09344_2.00 		Homo sapiens
GGGRHTTYCCC
GGGRAADYCCC		 Misc
Kulakovskiy et al.(2013)
NFKB2_HUMAN.H11MO.0.B 		0.988 0.988
NFKB2
M05700_2.00 		Homo sapiens
HGGKRNWTYCCCN
NGGGRAWNYMCCD		 SELEX
Yin et al.(2017)
NFKB2_eDBD_Methyl-HT-SELEX 		0.988 0.988
Nfkb2
M09356_2.00 		Mus musculus
GGGRHTTYCCC
GGGRAADYCCC		 Misc
Kulakovskiy et al.(2013)
NFKB2_MOUSE.H11MO.0.C 		0.963 0.963
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000189444 Rel 53 227

Links

Other Rel family TFs
Other Macaca fascicularis TFs

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50 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action