ENSP00000384273-D1 (Bos grunniens)
Rel

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00554 (RHD_DNA_bind) IPR011539 ENSP00000384273-D1 T317776_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Rela
M08039_2.00
Mus musculus
DGGRVTTTCCM

KGGAAABYCCH
ChIP-seq
Chen et al.(2011)
SRP001843_p65_Input_LPSstim
0.964 0.964
Rela
M08038_2.00
Mus musculus
HHYYYCYYNYHYYYNHYYYYCYWNNSYTBY

RVARSNNWRGRRRRDNRRRDRNRRGRRRDD
ChIP-seq
Chen et al.(2011)
SRP001843_p65_Input
0.964 0.964
Rela
M09355_2.00
Mus musculus
KGGRVTTYCCM

KGGRAABYCCM
Misc
Kulakovskiy et al.(2013)
TF65_MOUSE.H11MO.0.A
0.964 0.964
RELA
M02711_2.00
Homo sapiens
SGGRVTTTCC

GGAAABYCCS
SELEX
Mathelier et al.(2014)
MA0107.1
0.940 0.940
RELA
M07999_2.00
Homo sapiens
DGGGRMTTTCCMVN

NBKGGAAAKYCCCH
ChIP-seq
Gerstein et al.(2012)
GM10847_NFKB_Stanford
0.940 0.940
RELA
M08000_2.00
Homo sapiens
NDGGGRMWTTCCHN

NDGGAAWKYCCCHN
ChIP-seq
Gerstein et al.(2012)
GM12878_NFKB_Stanford
0.940 0.940
RELA
M08001_2.00
Homo sapiens
NDGGGRMTTTCCMVN

NBKGGAAAKYCCCHN
ChIP-seq
Gerstein et al.(2012)
GM12891_NFKB_Stanford
0.940 0.940
RELA
M08002_2.00
Homo sapiens
DGGGRHTTTCCMVNN

NNBKGGAAADYCCCH
ChIP-seq
Gerstein et al.(2012)
GM12892_NFKB_Stanford
0.940 0.940
RELA
M08003_2.00
Homo sapiens
DGGGRVTTTCCHVN

NBDGGAAABYCCCH
ChIP-seq
Gerstein et al.(2012)
GM15510_NFKB_Stanford
0.940 0.940
RELA
M08004_2.00
Homo sapiens
NDGGGRMTTTCCMNN

NNKGGAAAKYCCCHN
ChIP-seq
Gerstein et al.(2012)
GM18505_NFKB_Stanford
0.940 0.940
RELA
M08005_2.00
Homo sapiens
NDGGGRHTTTCCMVN

NBKGGAAADYCCCHN
ChIP-seq
Gerstein et al.(2012)
GM18526_NFKB_Stanford
0.940 0.940
RELA
M08006_2.00
Homo sapiens
GGGRVTTTCCM

KGGAAABYCCC
ChIP-seq
Gerstein et al.(2012)
GM18951_NFKB_Stanford
0.940 0.940
RELA
M08007_2.00
Homo sapiens
DGGGRMTTTCCMV

BKGGAAAKYCCCH
ChIP-seq
Gerstein et al.(2012)
GM19099_NFKB_Stanford
0.940 0.940
RELA
M08008_2.00
Homo sapiens
DGGGRMTTTCCMNNN

NNNKGGAAAKYCCCH
ChIP-seq
Gerstein et al.(2012)
GM19193_NFKB_Stanford
0.940 0.940
RELA
M09351_2.00
Homo sapiens
NWGGGRHWTTCCMV

BKGGAAWDYCCCWN
Misc
Kulakovskiy et al.(2013)
TF65_HUMAN.H11MO.0.A
0.940 0.940
RELA
M09626_2.00
Homo sapiens
DGGGRVWTTCCM

KGGAAWBYCCCH
Misc
Heinz et al.(2010)
GM12787-p65_GSE19485
0.940 0.940
RELA
M11237_2.00
Homo sapiens
BGGRVTTTCC

GGAAABYCCV
Transfac
Matys et al.(2006)
V$NFKAPPAB65_01
0.940 0.940
RELA
M11238_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$RELA_02
0.940 0.940
RELA
M11239_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$RELA_03
0.940 0.940
RELA
M11240_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$RELA_04
0.940 0.940
RELA
M11241_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$RELA_05
0.940 0.940
RELA
M11242_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$RELA_Q6
0.940 0.940
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000384273-D1 Rel 21 186

Links

Other Rel family TFs
Other Bos grunniens TFs

39 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
RELA Bos taurus ENSBTAG00000013895 I 1.000
ENSAMEG00000017369 Ailuropoda melanoleuca ENSAMEG00000017369 I 0.994
RELA Felis catus ENSFCAG00000005696 I 0.994
RELA Equus caballus ENSECAG00000013763 I 0.994
RELA Canis familiaris ENSCAFG00000013334 I 0.994
RELA Gorilla gorilla ENSGGOG00000011810 I 0.988
RELA Loxodonta africana ENSLAFG00000021967 I 0.988
RELA Sus scrofa ENSSSCG00000012981 I 0.988
Rela Rattus norvegicus ENSRNOG00000030888 I 0.988
RELA Homo sapiens ENSG00000173039 D 0.988
ENSNLEG00000005769 Nomascus leucogenys ENSNLEG00000005769 I 0.982
ENSPPYG00000003053 Pongo abelii ENSPPYG00000003053 I 0.982
ENSPANG00000013650 Papio anubis ENSPANG00000013650 I 0.982
RELA Tursiops truncatus ENSTTRG00000002311 I 0.982
RELA Pan troglodytes ENSPTRG00000003889 I 0.982
RELA Microcebus murinus ENSMICG00000008872 I 0.982
ENSP00000384273 Macaca fascicularis ENSP00000384273 I 0.982
RELA Pteropus vampyrus ENSPVAG00000009983 I 0.982
ENSCSAG00000007981 Chlorocebus sabaeus ENSCSAG00000007981 I 0.982
RELA Macaca mulatta ENSMMUG00000007418 I 0.982
RELA Callithrix jacchus ENSCJAG00000002037 I 0.982
RELA Dasypus novemcinctus ENSDNOG00000039743 I 0.982
RELA Cavia porcellus ENSCPOG00000020593 I 0.976
RELA Otolemur garnettii ENSOGAG00000014117 I 0.976
ENSSTOG00000027336 Ictidomys tridecemlineatus ENSSTOG00000027336 I 0.976
Myotis_brandtii_Rela_10030730 Myotis brandtii Myotis_brandtii_Rela_10030730 I 0.970
ENSOARG00000017426 Ovis aries ENSOARG00000017426 I 0.970
RELA Myotis lucifugus ENSMLUG00000008727 I 0.970
Rela Mus musculus ENSMUSG00000024927 D 0.964
RELA Sorex araneus ENSSARG00000003535 I 0.952
ENSMPUG00000011637 Mustela putorius furo ENSMPUG00000011637 I 0.928
RELA Monodelphis domestica ENSMODG00000009603 I 0.904
ENSPSIG00000002944 Pelodiscus sinensis ENSPSIG00000002944 I 0.795
Cmyd_10013204 Chelonia mydas Cmyd_10013204 I 0.783
rela Xenopus tropicalis XB-GENE-946506 I 0.765
rela.L Xenopus laevis XB-GENE-946512 I 0.765
Ogr00666 Ophisaurus gracilis Ogr00666 I 0.747
Pvit_10466 Pogona vitticeps Pvit_10466 I 0.729
ENSOPRG00000010827 Ochotona princeps ENSOPRG00000010827 I 0.729