RFX5 (Homo sapiens)
RFX

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02257 (RFX_DNA_binding) IPR003150 ENSG00000143390 T318250_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
RFX5
M03458_2.00
Homo sapiens
BGTTRCYATRGYAACV

BGTTRCYATRGYAACV
SELEX
Jolma et al.(2013)
RFX5_1
(Direct) (Direct)
RFX5
M03459_2.00
Homo sapiens
BGTTGCYATGGYAACV

BGTTRCCATRGCAACV
SELEX
Jolma et al.(2013)
RFX5_2
(Direct) (Direct)
RFX5
M03460_2.00
Homo sapiens
BGTTGCYATGGYAACV

BGTTRCCATRGCAACV
SELEX
Jolma et al.(2013)
RFX5_3
(Direct) (Direct)
RFX5
M05725_2.00
Homo sapiens
BGTTRCYANGBGTTGCYRN

NYRGCAACVCNTRGYAACV
SELEX
Yin et al.(2017)
RFX5_eDBD_HT-SELEX_1
(Direct) (Direct)
RFX5
M05726_2.00
Homo sapiens
NYRVYAACSGTTRCYAN

NTRGYAACSGTTRBYRN
SELEX
Yin et al.(2017)
RFX5_eDBD_HT-SELEX_2
(Direct) (Direct)
RFX5
M05727_2.00
Homo sapiens
BGTYRYYRNGBGTTGYYRN

NYRRCAACVCNYRRYRACV
SELEX
Yin et al.(2017)
RFX5_eDBD_Methyl-HT-SELEX_1
(Direct) (Direct)
RFX5
M05728_2.00
Homo sapiens
NTRGYAASSGTYRBYRN

NYRVYRACSSTTRCYAN
SELEX
Yin et al.(2017)
RFX5_eDBD_Methyl-HT-SELEX_2
(Direct) (Direct)
RFX5
M08009_2.00
Homo sapiens
KCRBYDGTTRCYRRG

CYYRGYAACHRVYGM
ChIP-seq
Gerstein et al.(2012)
GM12878_RFX5_Stanford
(Direct) (Direct)
RFX5
M08010_2.00
Homo sapiens
DBVBYDGTTGCYRGGBVRR

YYBVCCYRGCAACHRVBVH
ChIP-seq
Gerstein et al.(2012)
H1-hESC_RFX5_Stanford
(Direct) (Direct)
RFX5
M08011_2.00
Homo sapiens
TCVBYDGTTDCYRDG

CHYRGHAACHRVBGA
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_RFX5_Stanford
(Direct) (Direct)
RFX5
M08012_2.00
Homo sapiens
YDGTTRCYRKGBVRV

BYBVCMYRGYAACHR
ChIP-seq
Gerstein et al.(2012)
HepG2_RFX5_Stanford
(Direct) (Direct)
RFX5
M09364_2.00
Homo sapiens
VNNVBYDGTTGCYRKGNVRV

BYBNCMYRGCAACHRVBNNB
Misc
Kulakovskiy et al.(2013)
RFX5_HUMAN.H11MO.0.A
(Direct) (Direct)
RFX5
M09629_2.00
Homo sapiens
NDGTTRCYADGV

BCHTRGYAACHN
Misc
Heinz et al.(2010)
GM12878-Rfx5_GSE31477
(Direct) (Direct)
RFX5
M11249_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$RFX5_03
(Direct) (Direct)
RFX5
M11250_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$RFX5_05
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Rfx7
M00823_2.00
Mus musculus
GTYRCYRNSB

VSNYRGYRAC
PBM
Weirauch et al.(2013)
pTH3516
0.706 0.632
Rfx7
M00187_2.00
Mus musculus
BGTHDYYRNN

NNYRRHDACV
PBM
Badis et al.(2009)
Rfxdc2_3516
0.671 0.600
RFX7
M05729_2.00
Homo sapiens
BGTTRCYRY

RYRGYAACV
SELEX
Yin et al.(2017)
RFX7_eDBD_HT-SELEX
0.671 0.600
RFX7
M05730_2.00
Homo sapiens
BGTTGCYRB

VYRGCAACV
SELEX
Yin et al.(2017)
RFX7_eDBD_Methyl-HT-SELEX
0.665 0.655
For this family, TFs with SR scores > 0.650 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000290524 RFX 89 168
ENSP00000357864 RFX 89 168
ENSP00000376502 RFX 89 168
ENSP00000387618 RFX 89 123
ENSP00000389130 RFX 89 168
ENSP00000390769 RFX 1 60
ENSP00000396810 RFX 89 117
ENSP00000398666 RFX 89 168
ENSP00000399095 RFX 89 168
ENSP00000409187 RFX 89 165

Links

Other RFX family TFs
Other Homo sapiens TFs

228 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
SERLA73DRAFT_63698 Serpula lacrymans SERLA73DRAFT_63698 I 0.000
CY34DRAFT_46380 Suillus luteus CY34DRAFT_46380 N 0.000
M404DRAFT_998457 Pisolithus tinctorius M404DRAFT_998457 N 0.000
PAXINDRAFT_138635 Paxillus involutus PAXINDRAFT_138635 N 0.000
PISMIDRAFT_672010 Pisolithus microcarpus PISMIDRAFT_672010 N 0.000
PISMIDRAFT_690687 Pisolithus microcarpus PISMIDRAFT_690687 N 0.000
SCLCIDRAFT_101722 Scleroderma citrinum SCLCIDRAFT_101722 N 0.000