CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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RFX6
(
Homo sapiens
)
RFX
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF02257 (RFX_DNA_binding)
IPR003150
ENSG00000185002
T318252_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.[provided by RefSeq, Sep 2010]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Rfx6
M09365_2.00
Mus musculus
BDGTWKCYNDG
CHNRGMAACHV
Misc
Kulakovskiy et al.(2013)
RFX6_MOUSE.H11MO.0.C
0.794
0.987
RFX4
M02448_2.00
Cavia porcellus
GTHDYYNNGN
NCNNRRHDAC
PBM
Weirauch et al.(2014)
pTH9249
0.719
0.709
Rfx4
M00186_2.00
Mus musculus
GTHDYYNNSN
NSNNRRHDAC
PBM
Badis et al.(2009)
Rfx4_3761
0.719
0.709
RFX4
M03456_2.00
Homo sapiens
NGTWRYCATRGHWACN
NGTWDCYATGRYWACN
SELEX
Jolma et al.(2013)
RFX4_1
0.719
0.709
RFX4
M03457_2.00
Homo sapiens
NGTTGCYRRGCAACS
SGTTGCYYRGCAACN
SELEX
Jolma et al.(2013)
RFX4_2
0.719
0.709
RFX4
M05721_2.00
Homo sapiens
BGTWRYCATGRYWACV
BGTWRYCATGRYWACV
SELEX
Yin et al.(2017)
RFX4_eDBD_HT-SELEX
0.719
0.709
RFX4
M05722_2.00
Homo sapiens
BGTWRYCATGRYWACV
BGTWRYCATGRYWACV
SELEX
Yin et al.(2017)
RFX4_eDBD_Methyl-HT-SELEX
0.719
0.709
Rfx3
M00188_2.00
Mus musculus
SNTRRHDACN
NGTHDYYANS
PBM
Badis et al.(2009)
Rfx3_3961
0.688
0.608
Rfx3
M03463_2.00
Mus musculus
SGTTRCCATGGYAACS
SGTTRCCATGGYAACS
SELEX
Jolma et al.(2013)
Rfx3_1
0.688
0.608
Rfx3
M09368_2.00
Mus musculus
BBGTTGCCATGGNRAC
GTYNCCATGGCAACVV
Misc
Kulakovskiy et al.(2013)
RFX3_MOUSE.H11MO.0.C
0.688
0.608
RFX1
M02447_2.00
Anolis carolinensis
GTHRCYANGN
NCNTRGYDAC
PBM
Weirauch et al.(2014)
pTH9223
0.688
0.608
RFX1
M02451_2.00
Tetraodon nigroviridis
GTHDYYANGN
NCNTRRHDAC
PBM
Weirauch et al.(2014)
pTH9385
0.688
0.608
RFX1
M05723_2.00
Homo sapiens
BGTTRYCATGRYAACV
BGTTRYCATGRYAACV
SELEX
Yin et al.(2017)
RFX1_eDBD_HT-SELEX
0.688
0.608
Rfx1
M08162_2.00
Mus musculus
GTTGCYADGGNRAC
GTYNCCHTRGCAAC
ChIP-seq
Mathelier et al.(2014)
MA0509.1
0.688
0.608
RFX1
M09363_2.00
Homo sapiens
BBBSSNGTTGCCADGGNRMCVV
BBGKYNCCHTGGCAACNSSVVV
Misc
Kulakovskiy et al.(2013)
RFX1_HUMAN.H11MO.0.B
0.688
0.608
Rfx1
M09367_2.00
Mus musculus
BBBSSNGTTGCCADGGNRMCVV
BBGKYNCCHTGGCAACNSSVVV
Misc
Kulakovskiy et al.(2013)
RFX1_MOUSE.H11MO.0.A
0.688
0.608
RFX1
M11245_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EFC_Q6
0.688
0.608
RFX1
M11246_2.00
Homo sapiens
HNGTTRCYWVGYDMYNN
NNRKHRCBWRGYAACND
Transfac
Matys et al.(2006)
V$RFX1_01
0.688
0.608
RFX1
M11247_2.00
Homo sapiens
HNGTTRCYWBVGYDMYNN
NNRKHRCBVWRGYAACND
Transfac
Matys et al.(2006)
V$RFX1_02
0.688
0.608
RFX1
M11248_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$RFX1_Q6
0.688
0.608
RFX1
M05724_2.00
Homo sapiens
BGTWRYCATGRYWACV
BGTWRYCATGRYWACV
SELEX
Yin et al.(2017)
RFX1_eDBD_Methyl-HT-SELEX
0.688
0.608
G4VLF2_SCHMA
M02452_2.00
Schistosoma mansoni
GTTGCTAD
HTAGCAAC
PBM
Weirauch et al.(2014)
pTH8587
0.688
0.608
RFX2
M02449_2.00
Homo sapiens
BGTHRYYADG
CHTRRYDACV
PBM
Weirauch et al.(2014)
pTH9194
0.688
0.608
RFX2
M02450_2.00
Ornithorhynchus anatinus
NGTHRYYANV
BNTRRYDACN
PBM
Weirauch et al.(2014)
pTH9269
0.688
0.608
GB41876
M02453_2.00
Apis mellifera
GTHDCYANVN
NBNTRGHDAC
PBM
Weirauch et al.(2014)
pTH9226
0.687
0.595
Sjc_0102030
M02455_2.00
Schistosoma japonicum
GTTRCYANG
CNTRGYAAC
PBM
Weirauch et al.(2014)
pTH9285
0.686
0.595
XP_002157607.1
M02456_2.00
Hydra magnipapillata
GTHDYYDNVN
NBNHRRHDAC
PBM
Weirauch et al.(2014)
pTH9199
0.686
0.570
Rfx
M03959_2.00
Drosophila melanogaster
NGTHRCYATRGYDACN
NGTHRCYATRGYDACN
SELEX
Nitta et al.(2015)
Rfx_1
0.686
0.582
Rfx
M03960_2.00
Drosophila melanogaster
GTTGCTARGCAAC
GTTGCYTAGCAAC
SELEX
Nitta et al.(2015)
Rfx_2
0.686
0.582
Rfx
M03961_2.00
Drosophila melanogaster
BGTWRCCATGGYWACV
BGTWRCCATGGYWACV
SELEX
Nitta et al.(2015)
Rfx_3
0.686
0.582
Rfx
M03962_2.00
Drosophila melanogaster
GTTRCYAWTRGYAAC
GTTRCYAWTRGYAAC
SELEX
Nitta et al.(2015)
Rfx_4
0.686
0.582
Rfx
M03963_2.00
Drosophila melanogaster
GTTGCTARGCAAC
GTTGCYTAGCAAC
SELEX
Nitta et al.(2015)
Rfx_5
0.686
0.582
Rfx2
M03461_2.00
Mus musculus
BGTTRCCATGGYAACV
BGTTRCCATGGYAACV
SELEX
Jolma et al.(2013)
Rfx2_1
0.682
0.608
Rfx2
M03462_2.00
Mus musculus
SGTTGCTARGCAACV
BGTTGCYTAGCAACS
SELEX
Jolma et al.(2013)
Rfx2_2
0.682
0.608
Rfx2
M05888_2.00
Mus musculus
NGTTRCYATGGHDAY
RTHDCCATRGYAACN
SMiLE-seq
Isakova et al.(2017)
RFX2
0.682
0.608
Rfx2
M09366_2.00
Mus musculus
NBYBGTYNCCMTGGCAACNSSS
SSSNGTTGCCAKGGNRACVRVN
Misc
Kulakovskiy et al.(2013)
RFX2_MOUSE.H11MO.0.A
0.682
0.608
RFX3
M03452_2.00
Homo sapiens
NGTTRCCATGGHAACV
BGTTDCCATGGYAACN
SELEX
Jolma et al.(2013)
RFX3_1
0.681
0.595
RFX3
M03453_2.00
Homo sapiens
BGTTGCTARGCAACS
SGTTGCYTAGCAACV
SELEX
Jolma et al.(2013)
RFX3_2
0.681
0.595
RFX3
M02750_2.00
Homo sapiens
GTTRYYATGG
CCATRRYAAC
SELEX
Jolma et al.(2010)
RFX3_dimer
0.681
0.595
RFX3
M05715_2.00
Homo sapiens
NGTTRYYATRRYAACN
NGTTRYYATRRYAACN
SELEX
Yin et al.(2017)
RFX3_eDBD_HT-SELEX_1
0.681
0.595
RFX3
M05716_2.00
Homo sapiens
BGTTGCTARGCAACS
SGTTGCYTAGCAACV
SELEX
Yin et al.(2017)
RFX3_eDBD_HT-SELEX_2
0.681
0.595
RFX3
M09361_2.00
Homo sapiens
BGTTRCCATGGYRN
NYRCCATGGYAACV
Misc
Kulakovskiy et al.(2013)
RFX3_HUMAN.H11MO.0.B
0.681
0.595
RFX3
M09627_2.00
Homo sapiens
BNGTTGCCATGGCAAC
GTTGCCATGGCAACNV
Misc
Heinz et al.(2010)
K562-RFX3_SRA012198
0.681
0.595
RFX3
M05717_2.00
Homo sapiens
BGTTRYYATRRYAACV
BGTTRYYATRRYAACV
SELEX
Yin et al.(2017)
RFX3_eDBD_Methyl-HT-SELEX_1
0.681
0.595
RFX3
M05718_2.00
Homo sapiens
BGTTGCTARGCAACV
BGTTGCYTAGCAACV
SELEX
Yin et al.(2017)
RFX3_eDBD_Methyl-HT-SELEX_2
0.681
0.595
daf-19
M00709_2.00
Caenorhabditis elegans
SGTTRCTADG
CHTAGYAACS
PBM
Narasimhan et al.(2015)
pTH10021
0.681
0.544
RFX2
M03454_2.00
Homo sapiens
BGTTRCCATGGYAACV
BGTTRCCATGGYAACV
SELEX
Jolma et al.(2013)
RFX2_1
0.680
0.595
RFX2
M03455_2.00
Homo sapiens
SGTTGCTARGCAACS
SGTTGCYTAGCAACS
SELEX
Jolma et al.(2013)
RFX2_2
0.680
0.595
RFX2
M05719_2.00
Homo sapiens
NGTWDYYATRRHWACN
NGTWDYYATRRHWACN
SELEX
Yin et al.(2017)
RFX2_eDBD_HT-SELEX
0.680
0.595
RFX2
M09362_2.00
Homo sapiens
YNGTTGCCATGGVRACVV
BBGTYBCCATGGCAACNR
Misc
Kulakovskiy et al.(2013)
RFX2_HUMAN.H11MO.0.A
0.680
0.595
RFX2
M09628_2.00
Homo sapiens
BGTTKCCATGGMAAC
GTTKCCATGGMAACV
Misc
Heinz et al.(2010)
LoVo-RFX2_GSE49402
0.680
0.595
RFX2
M05720_2.00
Homo sapiens
BGTTRCCATGRYAACV
BGTTRYCATGGYAACV
SELEX
Yin et al.(2017)
RFX2_eDBD_Methyl-HT-SELEX
0.680
0.595
PHUM046580
M02454_2.00
Pediculus humanus
NGTHDCYANV
BNTRGHDACN
PBM
Weirauch et al.(2014)
pTH9278
0.679
0.620
For this family, TFs with SR scores >
0.650
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000332208
RFX
121
199
TQLTLQWLEENYIVCEGVCLPRCILYAHYLDFCRKEKLEPACAATFGKTIRQKFPLLTTRRLGTRGHSKYHYYGIGIKE
Links
Other
RFX
family TFs
Other
Homo sapiens
TFs
564 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy