Rfx5 (Rattus norvegicus)
RFX

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02257 (RFX_DNA_binding) IPR003150 ENSRNOG00000021012 T318489_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be part of RNA polymerase II transcription regulator complex. Human ortholog(s) of this gene implicated in MHC class II deficiency and severe combined immunodeficiency. Orthologous to human RFX5 (regulatory factor X5). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
RFX5
M03458_2.00 		Homo sapiens
BGTTRCYATRGYAACV
BGTTRCYATRGYAACV		 SELEX
Jolma et al.(2013)
RFX5_1 		0.790 0.987
RFX5
M03459_2.00 		Homo sapiens
BGTTGCYATGGYAACV
BGTTRCCATRGCAACV		 SELEX
Jolma et al.(2013)
RFX5_2 		0.790 0.987
RFX5
M03460_2.00 		Homo sapiens
BGTTGCYATGGYAACV
BGTTRCCATRGCAACV		 SELEX
Jolma et al.(2013)
RFX5_3 		0.790 0.987
RFX5
M05725_2.00 		Homo sapiens
BGTTRCYANGBGTTGCYRN
NYRGCAACVCNTRGYAACV		 SELEX
Yin et al.(2017)
RFX5_eDBD_HT-SELEX_1 		0.790 0.987
RFX5
M05726_2.00 		Homo sapiens
NYRVYAACSGTTRCYAN
NTRGYAACSGTTRBYRN		 SELEX
Yin et al.(2017)
RFX5_eDBD_HT-SELEX_2 		0.790 0.987
RFX5
M08009_2.00 		Homo sapiens
KCRBYDGTTRCYRRG
CYYRGYAACHRVYGM		 ChIP-seq
Gerstein et al.(2012)
GM12878_RFX5_Stanford 		0.790 0.987
RFX5
M08010_2.00 		Homo sapiens
DBVBYDGTTGCYRGGBVRR
YYBVCCYRGCAACHRVBVH		 ChIP-seq
Gerstein et al.(2012)
H1-hESC_RFX5_Stanford 		0.790 0.987
RFX5
M08011_2.00 		Homo sapiens
TCVBYDGTTDCYRDG
CHYRGHAACHRVBGA		 ChIP-seq
Gerstein et al.(2012)
HeLa-S3_RFX5_Stanford 		0.790 0.987
RFX5
M08012_2.00 		Homo sapiens
YDGTTRCYRKGBVRV
BYBVCMYRGYAACHR		 ChIP-seq
Gerstein et al.(2012)
HepG2_RFX5_Stanford 		0.790 0.987
RFX5
M09364_2.00 		Homo sapiens
VNNVBYDGTTGCYRKGNVRV
BYBNCMYRGCAACHRVBNNB		 Misc
Kulakovskiy et al.(2013)
RFX5_HUMAN.H11MO.0.A 		0.790 0.987
RFX5
M09629_2.00 		Homo sapiens
NDGTTRCYADGV
BCHTRGYAACHN		 Misc
Heinz et al.(2010)
GM12878-Rfx5_GSE31477 		0.790 0.987
RFX5
M11249_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RFX5_03 		0.790 0.987
RFX5
M11250_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RFX5_05 		0.790 0.987
RFX5
M05727_2.00 		Homo sapiens
BGTYRYYRNGBGTTGYYRN
NYRRCAACVCNYRRYRACV		 SELEX
Yin et al.(2017)
RFX5_eDBD_Methyl-HT-SELEX_1 		0.790 0.987
RFX5
M05728_2.00 		Homo sapiens
NTRGYAASSGTYRBYRN
NYRVYRACSSTTRCYAN		 SELEX
Yin et al.(2017)
RFX5_eDBD_Methyl-HT-SELEX_2 		0.790 0.987
Rfx7
M00823_2.00 		Mus musculus
GTYRCYRNSB
VSNYRGYRAC		 PBM
Weirauch et al.(2013)
pTH3516 		0.710 0.620
Rfx7
M00187_2.00 		Mus musculus
BGTHDYYRNN
NNYRRHDACV		 PBM
Badis et al.(2009)
Rfxdc2_3516 		0.710 0.620
RFX7
M05729_2.00 		Homo sapiens
BGTTRCYRY
RYRGYAACV		 SELEX
Yin et al.(2017)
RFX7_eDBD_HT-SELEX 		0.710 0.620
RFX7
M05730_2.00 		Homo sapiens
BGTTGCYRB
VYRGCAACV		 SELEX
Yin et al.(2017)
RFX7_eDBD_Methyl-HT-SELEX 		0.710 0.620
For this family, TFs with SR scores > 0.650 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSRNOP00000060480 RFX 88 167

Links

Other RFX family TFs
Other Rattus norvegicus TFs

Invalid Input OrderBy

227 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action