ENSP00000366022-D1 (Bos grunniens)
RFX

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF02257 (RFX_DNA_binding) IPR003150 ENSP00000366022-D1 T318981_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
PHUM046580
M02454_2.00
Pediculus humanus
NGTHDCYANV

BNTRGHDACN
PBM
Weirauch et al.(2014)
pTH9278
0.666 0.500
G4VLF2_SCHMA
M02452_2.00
Schistosoma mansoni
GTTGCTAD

HTAGCAAC
PBM
Weirauch et al.(2014)
pTH8587
0.662 0.514
RFX1
M02447_2.00
Anolis carolinensis
GTHRCYANGN

NCNTRGYDAC
PBM
Weirauch et al.(2014)
pTH9223
0.662 0.486
RFX1
M02451_2.00
Tetraodon nigroviridis
GTHDYYANGN

NCNTRRHDAC
PBM
Weirauch et al.(2014)
pTH9385
0.662 0.486
RFX1
M05723_2.00
Homo sapiens
BGTTRYCATGRYAACV

BGTTRYCATGRYAACV
SELEX
Yin et al.(2017)
RFX1_eDBD_HT-SELEX
0.662 0.486
Rfx1
M08162_2.00
Mus musculus
GTTGCYADGGNRAC

GTYNCCHTRGCAAC
ChIP-seq
Mathelier et al.(2014)
MA0509.1
0.662 0.486
RFX1
M09363_2.00
Homo sapiens
BBBSSNGTTGCCADGGNRMCVV

BBGKYNCCHTGGCAACNSSVVV
Misc
Kulakovskiy et al.(2013)
RFX1_HUMAN.H11MO.0.B
0.662 0.486
Rfx1
M09367_2.00
Mus musculus
BBBSSNGTTGCCADGGNRMCVV

BBGKYNCCHTGGCAACNSSVVV
Misc
Kulakovskiy et al.(2013)
RFX1_MOUSE.H11MO.0.A
0.662 0.486
RFX1
M11245_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EFC_Q6
0.662 0.486
RFX1
M11246_2.00
Homo sapiens
HNGTTRCYWVGYDMYNN

NNRKHRCBWRGYAACND
Transfac
Matys et al.(2006)
V$RFX1_01
0.662 0.486
RFX1
M11247_2.00
Homo sapiens
HNGTTRCYWBVGYDMYNN

NNRKHRCBVWRGYAACND
Transfac
Matys et al.(2006)
V$RFX1_02
0.662 0.486
RFX1
M11248_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$RFX1_Q6
0.662 0.486
RFX1
M05724_2.00
Homo sapiens
BGTWRYCATGRYWACV

BGTWRYCATGRYWACV
SELEX
Yin et al.(2017)
RFX1_eDBD_Methyl-HT-SELEX
0.662 0.486
Rfx3
M00188_2.00
Mus musculus
SNTRRHDACN

NGTHDYYANS
PBM
Badis et al.(2009)
Rfx3_3961
0.662 0.472
RFX3
M03452_2.00
Homo sapiens
NGTTRCCATGGHAACV

BGTTDCCATGGYAACN
SELEX
Jolma et al.(2013)
RFX3_1
0.662 0.472
RFX3
M03453_2.00
Homo sapiens
BGTTGCTARGCAACS

SGTTGCYTAGCAACV
SELEX
Jolma et al.(2013)
RFX3_2
0.662 0.472
Rfx3
M03463_2.00
Mus musculus
SGTTRCCATGGYAACS

SGTTRCCATGGYAACS
SELEX
Jolma et al.(2013)
Rfx3_1
0.662 0.472
RFX3
M02750_2.00
Homo sapiens
GTTRYYATGG

CCATRRYAAC
SELEX
Jolma et al.(2010)
RFX3_dimer
0.662 0.472
RFX3
M05715_2.00
Homo sapiens
NGTTRYYATRRYAACN

NGTTRYYATRRYAACN
SELEX
Yin et al.(2017)
RFX3_eDBD_HT-SELEX_1
0.662 0.472
RFX3
M05716_2.00
Homo sapiens
BGTTGCTARGCAACS

SGTTGCYTAGCAACV
SELEX
Yin et al.(2017)
RFX3_eDBD_HT-SELEX_2
0.662 0.472
RFX3
M09361_2.00
Homo sapiens
BGTTRCCATGGYRN

NYRCCATGGYAACV
Misc
Kulakovskiy et al.(2013)
RFX3_HUMAN.H11MO.0.B
0.662 0.472
Rfx3
M09368_2.00
Mus musculus
BBGTTGCCATGGNRAC

GTYNCCATGGCAACVV
Misc
Kulakovskiy et al.(2013)
RFX3_MOUSE.H11MO.0.C
0.662 0.472
RFX3
M09627_2.00
Homo sapiens
BNGTTGCCATGGCAAC

GTTGCCATGGCAACNV
Misc
Heinz et al.(2010)
K562-RFX3_SRA012198
0.662 0.472
RFX3
M05717_2.00
Homo sapiens
BGTTRYYATRRYAACV

BGTTRYYATRRYAACV
SELEX
Yin et al.(2017)
RFX3_eDBD_Methyl-HT-SELEX_1
0.662 0.472
RFX3
M05718_2.00
Homo sapiens
BGTTGCTARGCAACV

BGTTGCYTAGCAACV
SELEX
Yin et al.(2017)
RFX3_eDBD_Methyl-HT-SELEX_2
0.662 0.472
RFX2
M02449_2.00
Homo sapiens
BGTHRYYADG

CHTRRYDACV
PBM
Weirauch et al.(2014)
pTH9194
0.661 0.486
RFX2
M02450_2.00
Ornithorhynchus anatinus
NGTHRYYANV

BNTRRYDACN
PBM
Weirauch et al.(2014)
pTH9269
0.661 0.486
RFX2
M03454_2.00
Homo sapiens
BGTTRCCATGGYAACV

BGTTRCCATGGYAACV
SELEX
Jolma et al.(2013)
RFX2_1
0.661 0.486
RFX2
M03455_2.00
Homo sapiens
SGTTGCTARGCAACS

SGTTGCYTAGCAACS
SELEX
Jolma et al.(2013)
RFX2_2
0.661 0.486
RFX2
M05719_2.00
Homo sapiens
NGTWDYYATRRHWACN

NGTWDYYATRRHWACN
SELEX
Yin et al.(2017)
RFX2_eDBD_HT-SELEX
0.661 0.486
RFX2
M09362_2.00
Homo sapiens
YNGTTGCCATGGVRACVV

BBGTYBCCATGGCAACNR
Misc
Kulakovskiy et al.(2013)
RFX2_HUMAN.H11MO.0.A
0.661 0.486
RFX2
M09628_2.00
Homo sapiens
BGTTKCCATGGMAAC

GTTKCCATGGMAACV
Misc
Heinz et al.(2010)
LoVo-RFX2_GSE49402
0.661 0.486
RFX2
M05720_2.00
Homo sapiens
BGTTRCCATGRYAACV

BGTTRYCATGGYAACV
SELEX
Yin et al.(2017)
RFX2_eDBD_Methyl-HT-SELEX
0.661 0.486
daf-19
M00709_2.00
Caenorhabditis elegans
SGTTRCTADG

CHTAGYAACS
PBM
Narasimhan et al.(2015)
pTH10021
0.661 0.486
Rfx6
M09365_2.00
Mus musculus
BDGTWKCYNDG

CHNRGMAACHV
Misc
Kulakovskiy et al.(2013)
RFX6_MOUSE.H11MO.0.C
0.661 0.472
Sjc_0102030
M02455_2.00
Schistosoma japonicum
GTTRCYANG

CNTRGYAAC
PBM
Weirauch et al.(2014)
pTH9285
0.661 0.500
Rfx2
M03461_2.00
Mus musculus
BGTTRCCATGGYAACV

BGTTRCCATGGYAACV
SELEX
Jolma et al.(2013)
Rfx2_1
0.661 0.486
Rfx2
M03462_2.00
Mus musculus
SGTTGCTARGCAACV

BGTTGCYTAGCAACS
SELEX
Jolma et al.(2013)
Rfx2_2
0.661 0.486
Rfx2
M05888_2.00
Mus musculus
NGTTRCYATGGHDAY

RTHDCCATRGYAACN
SMiLE-seq
Isakova et al.(2017)
RFX2
0.661 0.486
Rfx2
M09366_2.00
Mus musculus
NBYBGTYNCCMTGGCAACNSSS

SSSNGTTGCCAKGGNRACVRVN
Misc
Kulakovskiy et al.(2013)
RFX2_MOUSE.H11MO.0.A
0.661 0.486
Rfx4
M00186_2.00
Mus musculus
GTHDYYNNSN

NSNNRRHDAC
PBM
Badis et al.(2009)
Rfx4_3761
0.660 0.472
RFX4
M03456_2.00
Homo sapiens
NGTWRYCATRGHWACN

NGTWDCYATGRYWACN
SELEX
Jolma et al.(2013)
RFX4_1
0.660 0.472
RFX4
M03457_2.00
Homo sapiens
NGTTGCYRRGCAACS

SGTTGCYYRGCAACN
SELEX
Jolma et al.(2013)
RFX4_2
0.660 0.472
RFX4
M05721_2.00
Homo sapiens
BGTWRYCATGRYWACV

BGTWRYCATGRYWACV
SELEX
Yin et al.(2017)
RFX4_eDBD_HT-SELEX
0.660 0.472
RFX4
M05722_2.00
Homo sapiens
BGTWRYCATGRYWACV

BGTWRYCATGRYWACV
SELEX
Yin et al.(2017)
RFX4_eDBD_Methyl-HT-SELEX
0.660 0.472
RFX4
M02448_2.00
Cavia porcellus
GTHDYYNNGN

NCNNRRHDAC
PBM
Weirauch et al.(2014)
pTH9249
0.660 0.458
XP_002157607.1
M02456_2.00
Hydra magnipapillata
GTHDYYDNVN

NBNHRRHDAC
PBM
Weirauch et al.(2014)
pTH9199
0.659 0.458
GB41876
M02453_2.00
Apis mellifera
GTHDCYANVN

NBNTRGHDAC
PBM
Weirauch et al.(2014)
pTH9226
0.658 0.472
Rfx
M03959_2.00
Drosophila melanogaster
NGTHRCYATRGYDACN

NGTHRCYATRGYDACN
SELEX
Nitta et al.(2015)
Rfx_1
0.655 0.472
Rfx
M03960_2.00
Drosophila melanogaster
GTTGCTARGCAAC

GTTGCYTAGCAAC
SELEX
Nitta et al.(2015)
Rfx_2
0.655 0.472
Rfx
M03961_2.00
Drosophila melanogaster
BGTWRCCATGGYWACV

BGTWRCCATGGYWACV
SELEX
Nitta et al.(2015)
Rfx_3
0.655 0.472
Rfx
M03962_2.00
Drosophila melanogaster
GTTRCYAWTRGYAAC

GTTRCYAWTRGYAAC
SELEX
Nitta et al.(2015)
Rfx_4
0.655 0.472
Rfx
M03963_2.00
Drosophila melanogaster
GTTGCTARGCAAC

GTTGCYTAGCAAC
SELEX
Nitta et al.(2015)
Rfx_5
0.655 0.472
For this family, TFs with SR scores > 0.650 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000366022-D1 RFX 1 72

Links

Other RFX family TFs
Other Bos grunniens TFs

531 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
PK07026.1 Cannabis sativa PK07026.1 N 0.000
Cucsa.053270 Cucumis sativus Cucsa.053270 N 0.000
cassava24578.valid.m1 Manihot esculenta cassava24578.valid.m1 N 0.000
Pm029452 Prunus mume Pm029452 N 0.000
Ca_06943 Cicer arietinum Ca_06943 N 0.000
VIT_19s0014g04940 Vitis vinifera VIT_19s0014g04940 N 0.000
TRIUR3_35245 Triticum urartu TRIUR3_35245 N 0.000
Traes_2DS_2D035BAFD Triticum aestivum Traes_2DS_2D035BAFD N 0.000
Traes_2BS_4600D4B54 Triticum aestivum Traes_2BS_4600D4B54 N 0.000
Traes_2AS_620B821281 Triticum aestivum Traes_2AS_620B821281 N 0.000
TCM_031132 Theobroma cacao TCM_031132 N 0.000
Solyc12g005340.1 Solanum lycopersicum Solyc12g005340.1 N 0.000
Solyc07g063940.1 Solanum lycopersicum Solyc07g063940.1 N 0.000
mgf007614m Mimulus guttatus mgf007614m N 0.000
Aquca_005_00404 Aquilegia coerulea Aquca_005_00404 N 0.000
Ciclev10007843m.g Citrus clementina Ciclev10007843m.g N 0.000
SapurV1A.3085s0020 Salix purpurea SapurV1A.3085s0020 N 0.000
SapurV1A.0327s0070 Salix purpurea SapurV1A.0327s0070 N 0.000
Pavir.J35699 Panicum virgatum Pavir.J35699 N 0.000
orange1.1g040563m.g Citrus sinensis orange1.1g040563m.g N 0.000
MDP0000205622 Malus domestica MDP0000205622 N 0.000
Lus10036623.g Linum usitatissimum Lus10036623.g N 0.000
Lus10035840.g Linum usitatissimum Lus10035840.g N 0.000
Gorai.013G164700 Gossypium raimondii Gorai.013G164700 N 0.000
Gorai.009G427800 Gossypium raimondii Gorai.009G427800 N 0.000
Gorai.002G080600 Gossypium raimondii Gorai.002G080600 N 0.000
gene03285-v1.0-hybrid Fragaria vesca gene03285-v1.0-hybrid N 0.000
Eucgr.F03414 Eucalyptus grandis Eucgr.F03414 N 0.000
Si029156m.g Setaria italica Si029156m.g N 0.000
Sb02g035680 Sorghum bicolor Sb02g035680 N 0.000
MTR_2g082090 Medicago truncatula MTR_2g082090 N 0.000
MLOC_37712 Hordeum vulgare MLOC_37712 N 0.000
LPERR07G15240 Leersia perrieri LPERR07G15240 N 0.000
GSMUA_Achr6G24310_001 Musa acuminata GSMUA_Achr6G24310_001 N 0.000
GRMZM5G821439 Zea mays GRMZM5G821439 N 0.000
GLYMA13G36120 Glycine max GLYMA13G36120 N 0.000
GLYMA12G34420 Glycine max GLYMA12G34420 N 0.000
GLYMA12G16750 Glycine max GLYMA12G16750 N 0.000
GLYMA06G41500 Glycine max GLYMA06G41500 N 0.000
F775_07373 Aegilops tauschii F775_07373 N 0.000
BRADI1G25370 Brachypodium distachyon BRADI1G25370 N 0.000
BGIOSGA025902 Oryza indica BGIOSGA025902 N 0.000
OB07G23640 Oryza brachyantha OB07G23640 N 0.000
OBART07G17780 Oryza barthii OBART07G17780 N 0.000
OGLUM07G17420 Oryza glumaepatula OGLUM07G17420 N 0.000
PRUPE_ppa003323mg Prunus persica PRUPE_ppa003323mg N 0.000
POPTR_0011s13460 Populus trichocarpa POPTR_0011s13460 N 0.000
POPTR_0001s44090 Populus trichocarpa POPTR_0001s44090 N 0.000
PGSC0003DMG400021802 Solanum tuberosum PGSC0003DMG400021802 N 0.000
PGSC0003DMG400019232 Solanum tuberosum PGSC0003DMG400019232 N 0.000
CIGR1 Oryza sativa OS07G0545800 N 0.000
ORUFI07G18480 Oryza rufipogon ORUFI07G18480 N 0.000
ORGLA07G0142600 Oryza glaberrima ORGLA07G0142600 N 0.000
OPUNC07G16570 Oryza punctata OPUNC07G16570 N 0.000
ONIVA07G16090 Oryza nivara ONIVA07G16090 N 0.000
OMERI07G14660 Oryza meridionalis OMERI07G14660 N 0.000
OLONG_024541 Oryza longistaminata OLONG_024541 N 0.000
AMTR_s00043p00136400 Amborella trichopoda AMTR_s00043p00136400 N 0.000