ENSP00000389130 (Macaca fascicularis)
RFX

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF02257 (RFX_DNA_binding) IPR003150 ENSP00000389130 T318985_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
RFX5
M03458_2.00 		Homo sapiens
BGTTRCYATRGYAACV
BGTTRCYATRGYAACV		 SELEX
Jolma et al.(2013)
RFX5_1 		0.792 1.000
RFX5
M03459_2.00 		Homo sapiens
BGTTGCYATGGYAACV
BGTTRCCATRGCAACV		 SELEX
Jolma et al.(2013)
RFX5_2 		0.792 1.000
RFX5
M03460_2.00 		Homo sapiens
BGTTGCYATGGYAACV
BGTTRCCATRGCAACV		 SELEX
Jolma et al.(2013)
RFX5_3 		0.792 1.000
RFX5
M05725_2.00 		Homo sapiens
BGTTRCYANGBGTTGCYRN
NYRGCAACVCNTRGYAACV		 SELEX
Yin et al.(2017)
RFX5_eDBD_HT-SELEX_1 		0.792 1.000
RFX5
M05726_2.00 		Homo sapiens
NYRVYAACSGTTRCYAN
NTRGYAACSGTTRBYRN		 SELEX
Yin et al.(2017)
RFX5_eDBD_HT-SELEX_2 		0.792 1.000
RFX5
M08009_2.00 		Homo sapiens
KCRBYDGTTRCYRRG
CYYRGYAACHRVYGM		 ChIP-seq
Gerstein et al.(2012)
GM12878_RFX5_Stanford 		0.792 1.000
RFX5
M08010_2.00 		Homo sapiens
DBVBYDGTTGCYRGGBVRR
YYBVCCYRGCAACHRVBVH		 ChIP-seq
Gerstein et al.(2012)
H1-hESC_RFX5_Stanford 		0.792 1.000
RFX5
M08011_2.00 		Homo sapiens
TCVBYDGTTDCYRDG
CHYRGHAACHRVBGA		 ChIP-seq
Gerstein et al.(2012)
HeLa-S3_RFX5_Stanford 		0.792 1.000
RFX5
M08012_2.00 		Homo sapiens
YDGTTRCYRKGBVRV
BYBVCMYRGYAACHR		 ChIP-seq
Gerstein et al.(2012)
HepG2_RFX5_Stanford 		0.792 1.000
RFX5
M09364_2.00 		Homo sapiens
VNNVBYDGTTGCYRKGNVRV
BYBNCMYRGCAACHRVBNNB		 Misc
Kulakovskiy et al.(2013)
RFX5_HUMAN.H11MO.0.A 		0.792 1.000
RFX5
M09629_2.00 		Homo sapiens
NDGTTRCYADGV
BCHTRGYAACHN		 Misc
Heinz et al.(2010)
GM12878-Rfx5_GSE31477 		0.792 1.000
RFX5
M11249_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RFX5_03 		0.792 1.000
RFX5
M11250_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RFX5_05 		0.792 1.000
RFX5
M05727_2.00 		Homo sapiens
BGTYRYYRNGBGTTGYYRN
NYRRCAACVCNYRRYRACV		 SELEX
Yin et al.(2017)
RFX5_eDBD_Methyl-HT-SELEX_1 		0.792 1.000
RFX5
M05728_2.00 		Homo sapiens
NTRGYAASSGTYRBYRN
NYRVYRACSSTTRCYAN		 SELEX
Yin et al.(2017)
RFX5_eDBD_Methyl-HT-SELEX_2 		0.792 1.000
Rfx7
M00823_2.00 		Mus musculus
GTYRCYRNSB
VSNYRGYRAC		 PBM
Weirauch et al.(2013)
pTH3516 		0.710 0.620
Rfx7
M00187_2.00 		Mus musculus
BGTHDYYRNN
NNYRRHDACV		 PBM
Badis et al.(2009)
Rfxdc2_3516 		0.710 0.620
RFX7
M05729_2.00 		Homo sapiens
BGTTRCYRY
RYRGYAACV		 SELEX
Yin et al.(2017)
RFX7_eDBD_HT-SELEX 		0.710 0.620
RFX7
M05730_2.00 		Homo sapiens
BGTTGCYRB
VYRGCAACV		 SELEX
Yin et al.(2017)
RFX7_eDBD_Methyl-HT-SELEX 		0.710 0.620
For this family, TFs with SR scores > 0.650 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000389130 RFX 89 168

Links

Other RFX family TFs
Other Macaca fascicularis TFs

Invalid Input OrderBy

227 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action