ENSP00000352514 (Macaca fascicularis)
Runt

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00853 (Runt) IPR013524 ENSP00000352514 T319658_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Runx2
M01307_2.00
Mus musculus
NHDACCRCAN

NTGYGGTHDN
PBM
Lambert et al.(2019)
pTH9764
0.876 0.876
RUNX2
M03468_2.00
Homo sapiens
HRACCGCAAACCRCRD

HYGYGGTTTGCGGTYD
SELEX
Jolma et al.(2013)
RUNX2_1
0.876 0.876
RUNX2
M03469_2.00
Homo sapiens
HRACCRCADWWACCRCAD

HTGYGGTWWHTGYGGTYD
SELEX
Jolma et al.(2013)
RUNX2_2
0.876 0.876
RUNX2
M03470_2.00
Homo sapiens
WAACCRCAR

YTGYGGTTW
SELEX
Jolma et al.(2013)
RUNX2_3
0.876 0.876
RUNX2
M05733_2.00
Homo sapiens
NHRACCRCADWAACCRCAVN

NBTGYGGTTWHTGYGGTYDN
SELEX
Yin et al.(2017)
RUNX2_eDBD_HT-SELEX
0.876 0.876
RUNX2
M09370_2.00
Homo sapiens
MMHAACCACAVVMH

DKBBTGTGGTTDKK
Misc
Kulakovskiy et al.(2013)
RUNX2_HUMAN.H11MO.0.A
0.876 0.876
Runx2
M09373_2.00
Mus musculus
VWRACCACARVV

BBYTGTGGTYWB
Misc
Kulakovskiy et al.(2013)
RUNX2_MOUSE.H11MO.0.A
0.876 0.876
RUNX2
M09630_2.00
Homo sapiens
NHVACCACANNN

NNNTGTGGTBDN
Misc
Heinz et al.(2010)
PCa-RUNX2_GSE33889
0.876 0.876
RUNX2
M11255_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML3_Q3
0.876 0.876
RUNX2
M11256_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML3_Q6
0.876 0.876
RUNX2
M11257_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$OSF2_Q6
0.876 0.876
RUNX2
M05734_2.00
Homo sapiens
NWAACCACRAAAACCACRRN

NYYGTGGTTTTYGTGGTTWN
SELEX
Yin et al.(2017)
RUNX2_eDBD_Methyl-HT-SELEX
0.876 0.876
RUNX3
M03464_2.00
Homo sapiens
HRACCGCAAACCRCAN

NTGYGGTTTGCGGTYD
SELEX
Jolma et al.(2013)
RUNX3_1
0.857 0.857
RUNX3
M03465_2.00
Homo sapiens
WAACCRCARN

NYTGYGGTTW
SELEX
Jolma et al.(2013)
RUNX3_2
0.857 0.857
RUNX3
M03466_2.00
Homo sapiens
HDACCRCADWAACCRCRN

NYGYGGTTWHTGYGGTHD
SELEX
Jolma et al.(2013)
RUNX3_3
0.857 0.857
RUNX3
M03467_2.00
Homo sapiens
HRACCRCAAH

DTTGYGGTYD
SELEX
Jolma et al.(2013)
RUNX3_4
0.857 0.857
RUNX3
M02751_2.00
Homo sapiens
WACCRCAM

KTGYGGTW
SELEX
Jolma et al.(2010)
RUNX3_monomer
0.857 0.857
RUNX3
M05731_2.00
Homo sapiens
YWAACCGCAAAAACCGCARV

BYTGCGGTTTTTGCGGTTWR
SELEX
Yin et al.(2017)
RUNX3_FL_HT-SELEX
0.857 0.857
RUNX3
M09369_2.00
Homo sapiens
HAACCACARN

NYTGTGGTTD
Misc
Kulakovskiy et al.(2013)
RUNX3_HUMAN.H11MO.0.A
0.857 0.857
Runx3
M09374_2.00
Mus musculus
NHRACCACARVN

NBYTGTGGTYDN
Misc
Kulakovskiy et al.(2013)
RUNX3_MOUSE.H11MO.0.A
0.857 0.857
RUNX3
M11252_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML2_Q3_01
0.857 0.857
RUNX3
M11253_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML2_Q3
0.857 0.857
RUNX3
M11254_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML2_Q4
0.857 0.857
RUNX3
M05732_2.00
Homo sapiens
HWAACCACRAAAACCACRARN

NYTYGTGGTTTTYGTGGTTWD
SELEX
Yin et al.(2017)
RUNX3_FL_Methyl-HT-SELEX
0.857 0.857
Runx1
M08163_2.00
Mus musculus
HRRCCACARVN

NBYTGTGGYYD
ChIP-seq
Mathelier et al.(2014)
MA0002.2
0.819 0.819
RUNX1
M09371_2.00
Homo sapiens
NWAACCACARV

BYTGTGGTTWN
Misc
Kulakovskiy et al.(2013)
RUNX1_HUMAN.H11MO.0.A
0.819 0.819
Runx1
M09372_2.00
Mus musculus
VWRACCACARVV

BBYTGTGGTYWB
Misc
Kulakovskiy et al.(2013)
RUNX1_MOUSE.H11MO.0.A
0.819 0.819
RUNX1
M09632_2.00
Homo sapiens
HAACCACADV

BHTGTGGTTD
Misc
Heinz et al.(2010)
Jurkat-RUNX1_GSE29180
0.819 0.819
RUNX1
M09631_2.00
Homo sapiens
VCCACWTCCTBY

RVAGGAWGTGGB
Misc
Heinz et al.(2010)
Jurkat-RUNX1_GSE17954
0.819 0.819
Runx1
M09633_2.00
Mus musculus
NWAACCACAR

YTGTGGTTWN
Misc
Heinz et al.(2010)
HPC7-Runx1_GSE22178
0.819 0.819
RUNX1
M11258_2.00
Homo sapiens
ACCRCA

TGYGGT
Transfac
Matys et al.(2006)
V$AML1_01
0.819 0.819
RUNX1
M11259_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML1_Q4_01
0.819 0.819
RUNX1
M11260_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML1_Q4_02
0.819 0.819
RUNX1
M11261_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML1_Q4
0.819 0.819
RUNX1
M11262_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML1_Q5
0.819 0.819
RUNX1
M11263_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML1_Q6
0.819 0.819
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000352514 Runt 72 177

Links

Other Runt family TFs
Other Macaca fascicularis TFs

137 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
AAEL006160 Aedes aegypti AAEL006160 I 0.714
ENSAMEG00000009223 Ailuropoda melanoleuca ENSAMEG00000009223 I 1.000
Alligator_sinensis_CCG010991.1 Alligator sinensis Alligator_sinensis_CCG010991.1 I 0.973
ENSAPLG00000011653 Anas platyrhynchos ENSAPLG00000011653 I 0.978
ENSAPLG00000007026 Anas platyrhynchos ENSAPLG00000007026 I 0.921
RUNX3 Anolis carolinensis ENSACAG00000017855 I 0.957
RUNX2 Anolis carolinensis ENSACAG00000013003 I 0.867
AALB007752 Anopheles albimanus AALB007752 I 0.725
AATE002063 Anopheles atroparvus AATE002063 I 0.714
AMAM011616 Anopheles maculatus AMAM011616 I 0.720
AQUA009446 Anopheles quadriannulatus AQUA009446 I 0.720
ASTEI07771 Anopheles stephensi ASTEI07771 I 0.714
Afo_R004888 Aptenodytes forsteri Afo_R004888 I 0.944
Afo_R012718 Aptenodytes forsteri Afo_R012718 I 0.810
Afo_R008955 Aptenodytes forsteri Afo_R008955 I 0.988
ENSAMXG00000000881 Astyanax mexicanus ENSAMXG00000000881 I 0.838
ENSAMXG00000017349 Astyanax mexicanus ENSAMXG00000017349 I 0.867
ENSAMXG00000012244 Astyanax mexicanus ENSAMXG00000012244 I 0.790
ENSAMXG00000004048 Astyanax mexicanus ENSAMXG00000004048 I 0.848
ACEP16400 Atta cephalotes ACEP16400 I 0.762
ENSBTAP00000006227-D1 Bos grunniens ENSBTAP00000006227-D1 I 1.000
RUNX3 Bos taurus ENSBTAG00000019800 I 0.838
RUNX2 Bos taurus ENSBTAG00000004104 I 0.876
Brh_R001637 Buceros rhinoceros Brh_R001637 I 0.944
Brh_R000794 Buceros rhinoceros Brh_R000794 I 0.978
RUNX3 Callithrix jacchus ENSCJAG00000020815 I 0.848
RUNX1 Callithrix jacchus ENSCJAG00000002816 I 0.960
Aan_R007315 Calypte anna Aan_R007315 I 0.944
Aan_R005895 Calypte anna Aan_R005895 I 0.838
Aan_R002212 Calypte anna Aan_R002212 I 0.796
Cflo_03911--XP_394014.2_APIME Camponotus floridanus Cflo_03911--XP_394014.2_APIME I 0.705
Cflo_03909--XP_394016.2_APIME Camponotus floridanus Cflo_03909--XP_394016.2_APIME I 0.705
RUNX2 Cavia porcellus ENSCPOG00000005277 I 0.876
ENSCPOG00000002684 Cavia porcellus ENSCPOG00000002684 I 0.829
Cmyd_10020455 Chelonia mydas Cmyd_10020455 I 0.867
ENSCSAG00000012528 Chlorocebus sabaeus ENSCSAG00000012528 I 0.876
ENSCING00000002253 Ciona intestinalis ENSCING00000002253 I 0.867
CpipJ_CPIJ016825 Culex pipiens CpipJ_CPIJ016825 I 0.711
CPIJ016825 Culex quinquefasciatus CPIJ016825 I 0.711
KGM_21065 Danaus plexippus KGM_21065 I 0.700
runx3 Danio rerio ENSDARG00000052826 I 0.848
runx2a Danio rerio ENSDARG00000040261 I 0.867
runx2b Danio rerio ENSDARG00000059233 I 0.974
CABZ01102124.1 Danio rerio ENSDARG00000103592 I 0.947
RUNX1 Dasypus novemcinctus ENSDNOG00000015041 I 0.810
RUNX2 Dasypus novemcinctus ENSDNOG00000034361 I 0.876
RUNX1 Equus caballus ENSECAG00000003462 I 0.810
RUNX2 Equus caballus ENSECAG00000020875 I 0.876
RUNX2 Erinaceus europaeus ENSEEUG00000009243 I 0.876
RUNX2 Felis catus ENSFCAG00000022480 I 1.000
ENSFCAG00000029032 Felis catus ENSFCAG00000029032 I 0.954
ENSFALG00000001493 Ficedula albicollis ENSFALG00000001493 I 0.848
ENSGALG00000026484 Gallus gallus ENSGALG00000026484 I 0.857
runx3 Gasterosteus aculeatus ENSGACG00000007301 I 0.848
runx2b Gasterosteus aculeatus ENSGACG00000012322 I 0.838
RUNX1 Gasterosteus aculeatus ENSGACG00000015276 I 0.790
Gfo_R013848 Geospiza fortis Gfo_R013848 I 0.974
Gfo_R000714 Geospiza fortis Gfo_R000714 I 0.857
Gfo_R011596 Geospiza fortis Gfo_R011596 I 0.744
RUNX2 Gorilla gorilla ENSGGOG00000012890 I 0.876
Hsal_12319--XP_394016.2_APIME Harpegnathos saltator Hsal_12319--XP_394016.2_APIME I 0.705
HMEL014739 Heliconius melpomene HMEL014739 I 0.700
RUNX2 Homo sapiens ENSG00000124813 D 0.876
ENSSTOG00000010163 Ictidomys tridecemlineatus ENSSTOG00000010163 I 0.876
ENSLACG00000015930 Latimeria chalumnae ENSLACG00000015930 I 0.771
ENSLACG00000013776 Latimeria chalumnae ENSLACG00000013776 I 0.800
ENSLACG00000011545 Latimeria chalumnae ENSLACG00000011545 I 0.876
ENSLOCG00000015816 Lepisosteus oculatus ENSLOCG00000015816 I 0.876
ENSLOCG00000002744 Lepisosteus oculatus ENSLOCG00000002744 I 0.838
RUNX2 Loxodonta africana ENSLAFG00000005054 I 1.000
LCUP002656 Lucilia cuprina LCUP002656 I 0.738
ENSP00000382800 Macaca fascicularis ENSP00000382800 I 0.876
ENSP00000300305 Macaca fascicularis ENSP00000300305 I 0.829
RUNX2 Macaca mulatta ENSMMUG00000019819 I 0.876
RUNX1 Macaca mulatta ENSMMUG00000001649 I 0.960
MESCA007078 Megaselia scalaris MESCA007078 I 0.730
MESCA007079 Megaselia scalaris MESCA007079 I 0.800
ENSMGAG00000014534 Meleagris gallopavo ENSMGAG00000014534 I 0.790
RUNX2 Meleagris gallopavo ENSMGAG00000014267 I 0.978
RUNX2 Monodelphis domestica ENSMODG00000018912 I 0.876
RUNX1 Monodelphis domestica ENSMODG00000021051 I 0.819
ENSMPUG00000015804 Mustela putorius furo ENSMPUG00000015804 I 0.857
ENSMPUG00000012508 Mustela putorius furo ENSMPUG00000012508 I 0.784
ENSMPUG00000001340 Mustela putorius furo ENSMPUG00000001340 I 0.810
Runx2 Mus musculus ENSMUSG00000039153 D 0.876
Runx1 Mus musculus ENSMUSG00000022952 D 0.806
Myotis_brandtii_RUNX2_10026084 Myotis brandtii Myotis_brandtii_RUNX2_10026084 I 0.708
RUNX2 Myotis lucifugus ENSMLUG00000000514 I 1.000
RUNX3 Myotis lucifugus ENSMLUG00000003395 I 0.848
ENSNLEG00000003611 Nomascus leucogenys ENSNLEG00000003611 I 0.783
ENSNLEG00000009021 Nomascus leucogenys ENSNLEG00000009021 I 0.838
ENSOPRG00000000765 Ochotona princeps ENSOPRG00000000765 I 0.819
RUNX2 Ochotona princeps ENSOPRG00000002943 I 0.876
ENSONIG00000008210 Oreochromis niloticus ENSONIG00000008210 I 0.848
RUNX2 Ornithorhynchus anatinus ENSOANG00000008265 I 1.000
ENSOANG00000031074 Ornithorhynchus anatinus ENSOANG00000031074 I 0.947
ENSOCUG00000011739 Oryctolagus cuniculus ENSOCUG00000011739 I 1.000
runx3 Oryzias latipes ENSORLG00000017515 I 0.848
RUNX2 Otolemur garnettii ENSOGAG00000003900 I 0.876
ENSOARG00000013599 Ovis aries ENSOARG00000013599 I 0.819
ENSOARG00000010358 Ovis aries ENSOARG00000010358 I 0.713
RUNX2 Pan troglodytes ENSPTRG00000018228 I 0.876
ENSPANG00000006186 Papio anubis ENSPANG00000006186 I 0.876
ENSPSIG00000014293 Pelodiscus sinensis ENSPSIG00000014293 I 0.967
PPAI006591 Phlebotomus papatasi PPAI006591 I 0.708
ENSPFOG00000003997 Poecilia formosa ENSPFOG00000003997 I 0.848
Pvit_17193 Pogona vitticeps Pvit_17193 I 0.700
Pvit_01165 Pogona vitticeps Pvit_01165 I 0.867
ENSPPYG00000016664 Pongo abelii ENSPPYG00000016664 I 0.876
ENSPPYG00000001714 Pongo abelii ENSPPYG00000001714 I 0.848
RUNX1 Pteropus vampyrus ENSPVAG00000001606 I 0.819
Runx2 Rattus norvegicus ENSRNOG00000020193 I 0.876
RPRC005391 Rhodnius prolixus RPRC005391 I 0.714
Sakowv30005496m.g Saccoglossus kowalevskii Sakowv30005496m.g I 0.762
ENSSHAG00000014782 Sarcophilus harrisii ENSSHAG00000014782 I 0.819
ENSSHAG00000009950 Sarcophilus harrisii ENSSHAG00000009950 I 0.876
ENSSHAG00000012559 Sarcophilus harrisii ENSSHAG00000012559 I 0.838
SINV13317 Solenopsis invicta SINV13317 I 0.705
ENSSSCG00000025551 Sus scrofa ENSSSCG00000025551 I 1.000
RUNX2 Taeniopygia guttata ENSTGUG00000013249 I 0.867
runx1 Takifugu rubripes ENSTRUG00000012611 I 0.781
runx2 Takifugu rubripes ENSTRUG00000003501 I 0.829
ENSTSYG00000005097 Tarsius syrichta ENSTSYG00000005097 I 0.790
tetur01g02340 Tetranychus urticae tetur01g02340 I 0.705
ENSTNIG00000018690 Tetraodon nigroviridis ENSTNIG00000018690 I 0.790
runx3 Tetraodon nigroviridis ENSTNIG00000016911 I 0.819
TC006536 Tribolium castaneum TC006536 I 0.705
RUNX2 Tupaia belangeri ENSTBEG00000000948 I 1.000
RUNX2 Tursiops truncatus ENSTTRG00000006943 I 0.876
RUNX1 Tursiops truncatus ENSTTRG00000014160 I 0.790
Tal_R011874 Tyto alba Tal_R011874 I 0.978
runx2.L Xenopus laevis XB-GENE-864817 I 0.848
runx1.L Xenopus laevis XB-GENE-864949 I 0.819
XP_002939386 Xenopus tropicalis XP_002939386 I 0.819
runx2 Xenopus tropicalis XB-GENE-482021 I 0.838
XP_002939387 Xenopus tropicalis XP_002939387 I 0.819
ENSXMAG00000018835 Xiphophorus maculatus ENSXMAG00000018835 I 0.848