ENSP00000382800 (Macaca fascicularis)
Runt

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00853 (Runt) IPR013524 ENSP00000382800 T319659_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
RUNX3
M03464_2.00
Homo sapiens
HRACCGCAAACCRCAN

NTGYGGTTTGCGGTYD
SELEX
Jolma et al.(2013)
RUNX3_1
0.886 0.886
RUNX3
M03465_2.00
Homo sapiens
WAACCRCARN

NYTGYGGTTW
SELEX
Jolma et al.(2013)
RUNX3_2
0.886 0.886
RUNX3
M03466_2.00
Homo sapiens
HDACCRCADWAACCRCRN

NYGYGGTTWHTGYGGTHD
SELEX
Jolma et al.(2013)
RUNX3_3
0.886 0.886
RUNX3
M03467_2.00
Homo sapiens
HRACCRCAAH

DTTGYGGTYD
SELEX
Jolma et al.(2013)
RUNX3_4
0.886 0.886
RUNX3
M02751_2.00
Homo sapiens
WACCRCAM

KTGYGGTW
SELEX
Jolma et al.(2010)
RUNX3_monomer
0.886 0.886
RUNX3
M05731_2.00
Homo sapiens
YWAACCGCAAAAACCGCARV

BYTGCGGTTTTTGCGGTTWR
SELEX
Yin et al.(2017)
RUNX3_FL_HT-SELEX
0.886 0.886
RUNX3
M09369_2.00
Homo sapiens
HAACCACARN

NYTGTGGTTD
Misc
Kulakovskiy et al.(2013)
RUNX3_HUMAN.H11MO.0.A
0.886 0.886
Runx3
M09374_2.00
Mus musculus
NHRACCACARVN

NBYTGTGGTYDN
Misc
Kulakovskiy et al.(2013)
RUNX3_MOUSE.H11MO.0.A
0.886 0.886
RUNX3
M11252_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML2_Q3_01
0.886 0.886
RUNX3
M11253_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML2_Q3
0.886 0.886
RUNX3
M11254_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML2_Q4
0.886 0.886
RUNX3
M05732_2.00
Homo sapiens
HWAACCACRAAAACCACRARN

NYTYGTGGTTTTYGTGGTTWD
SELEX
Yin et al.(2017)
RUNX3_FL_Methyl-HT-SELEX
0.886 0.886
Runx2
M01307_2.00
Mus musculus
NHDACCRCAN

NTGYGGTHDN
PBM
Lambert et al.(2019)
pTH9764
0.867 0.867
RUNX2
M03468_2.00
Homo sapiens
HRACCGCAAACCRCRD

HYGYGGTTTGCGGTYD
SELEX
Jolma et al.(2013)
RUNX2_1
0.867 0.867
RUNX2
M03469_2.00
Homo sapiens
HRACCRCADWWACCRCAD

HTGYGGTWWHTGYGGTYD
SELEX
Jolma et al.(2013)
RUNX2_2
0.867 0.867
RUNX2
M03470_2.00
Homo sapiens
WAACCRCAR

YTGYGGTTW
SELEX
Jolma et al.(2013)
RUNX2_3
0.867 0.867
RUNX2
M05733_2.00
Homo sapiens
NHRACCRCADWAACCRCAVN

NBTGYGGTTWHTGYGGTYDN
SELEX
Yin et al.(2017)
RUNX2_eDBD_HT-SELEX
0.867 0.867
RUNX2
M09370_2.00
Homo sapiens
MMHAACCACAVVMH

DKBBTGTGGTTDKK
Misc
Kulakovskiy et al.(2013)
RUNX2_HUMAN.H11MO.0.A
0.867 0.867
Runx2
M09373_2.00
Mus musculus
VWRACCACARVV

BBYTGTGGTYWB
Misc
Kulakovskiy et al.(2013)
RUNX2_MOUSE.H11MO.0.A
0.867 0.867
RUNX2
M09630_2.00
Homo sapiens
NHVACCACANNN

NNNTGTGGTBDN
Misc
Heinz et al.(2010)
PCa-RUNX2_GSE33889
0.867 0.867
RUNX2
M11255_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML3_Q3
0.867 0.867
RUNX2
M11256_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML3_Q6
0.867 0.867
RUNX2
M11257_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$OSF2_Q6
0.867 0.867
RUNX2
M05734_2.00
Homo sapiens
NWAACCACRAAAACCACRRN

NYYGTGGTTTTYGTGGTTWN
SELEX
Yin et al.(2017)
RUNX2_eDBD_Methyl-HT-SELEX
0.867 0.867
Runx1
M08163_2.00
Mus musculus
HRRCCACARVN

NBYTGTGGYYD
ChIP-seq
Mathelier et al.(2014)
MA0002.2
0.829 0.829
RUNX1
M09371_2.00
Homo sapiens
NWAACCACARV

BYTGTGGTTWN
Misc
Kulakovskiy et al.(2013)
RUNX1_HUMAN.H11MO.0.A
0.829 0.829
Runx1
M09372_2.00
Mus musculus
VWRACCACARVV

BBYTGTGGTYWB
Misc
Kulakovskiy et al.(2013)
RUNX1_MOUSE.H11MO.0.A
0.829 0.829
RUNX1
M09632_2.00
Homo sapiens
HAACCACADV

BHTGTGGTTD
Misc
Heinz et al.(2010)
Jurkat-RUNX1_GSE29180
0.829 0.829
RUNX1
M09631_2.00
Homo sapiens
VCCACWTCCTBY

RVAGGAWGTGGB
Misc
Heinz et al.(2010)
Jurkat-RUNX1_GSE17954
0.829 0.829
Runx1
M09633_2.00
Mus musculus
NWAACCACAR

YTGTGGTTWN
Misc
Heinz et al.(2010)
HPC7-Runx1_GSE22178
0.829 0.829
RUNX1
M11258_2.00
Homo sapiens
ACCRCA

TGYGGT
Transfac
Matys et al.(2006)
V$AML1_01
0.829 0.829
RUNX1
M11259_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML1_Q4_01
0.829 0.829
RUNX1
M11260_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML1_Q4_02
0.829 0.829
RUNX1
M11261_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML1_Q4
0.829 0.829
RUNX1
M11262_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML1_Q5
0.829 0.829
RUNX1
M11263_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AML1_Q6
0.829 0.829
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000382800 Runt 4 109

Links

Other Runt family TFs
Other Macaca fascicularis TFs

194 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
RUNX3 Anolis carolinensis ENSACAG00000017855 I 0.978
ENSOANG00000031074 Ornithorhynchus anatinus ENSOANG00000031074 I 0.960
RUNX2 Meleagris gallopavo ENSMGAG00000014267 I 0.956
ENSAPLG00000011653 Anas platyrhynchos ENSAPLG00000011653 I 0.956
Brh_R000794 Buceros rhinoceros Brh_R000794 I 0.956
Tal_R011874 Tyto alba Tal_R011874 I 0.956
runx2b Danio rerio ENSDARG00000059233 I 0.949
ENSPSIG00000014293 Pelodiscus sinensis ENSPSIG00000014293 I 0.946
Brh_R001637 Buceros rhinoceros Brh_R001637 I 0.944
Afo_R004888 Aptenodytes forsteri Afo_R004888 I 0.944
Aan_R007315 Calypte anna Aan_R007315 I 0.944
ENSFCAG00000029032 Felis catus ENSFCAG00000029032 I 0.938
CABZ01102124.1 Danio rerio ENSDARG00000103592 I 0.921
ENSAPLG00000007026 Anas platyrhynchos ENSAPLG00000007026 I 0.895
ENSFALG00000000470 Ficedula albicollis ENSFALG00000000470 I 0.886
RUNX3 Dasypus novemcinctus ENSDNOG00000043493 I 0.886
ENSMPUG00000015804 Mustela putorius furo ENSMPUG00000015804 I 0.886
Cmyd_10020845 Chelonia mydas Cmyd_10020845 I 0.886
RUNX3 Taeniopygia guttata ENSTGUG00000001130 I 0.886
ENSMODG00000013941 Monodelphis domestica ENSMODG00000013941 I 0.886
RUNX3 Loxodonta africana ENSLAFG00000008382 I 0.886
ENSGALG00000026821 Gallus gallus ENSGALG00000026821 I 0.886
ENSAPLG00000016439 Anas platyrhynchos ENSAPLG00000016439 I 0.886
RUNX3 Callithrix jacchus ENSCJAG00000020815 I 0.876
ENSP00000352514 Macaca fascicularis ENSP00000352514 I 0.876
ENSMEUG00000014419 Macropus eugenii ENSMEUG00000014419 I 0.876
runx3 Xenopus tropicalis XB-GENE-487784 I 0.876
runx2a Danio rerio ENSDARG00000040261 I 0.876
Pvit_17193 Pogona vitticeps Pvit_17193 I 0.876
ENSAMEG00000009223 Ailuropoda melanoleuca ENSAMEG00000009223 I 0.876
ENSPPYG00000001714 Pongo abelii ENSPPYG00000001714 I 0.876
RUNX2 Bos taurus ENSBTAG00000004104 I 0.867
Runx2 Rattus norvegicus ENSRNOG00000020193 I 0.867
RUNX2 Homo sapiens ENSG00000124813 D 0.867
ENSSHAG00000009950 Sarcophilus harrisii ENSSHAG00000009950 I 0.867
RUNX2 Monodelphis domestica ENSMODG00000018912 I 0.867
ENSLOCG00000015816 Lepisosteus oculatus ENSLOCG00000015816 I 0.867
RUNX2 Tursiops truncatus ENSTTRG00000006943 I 0.867
ENSLACG00000011545 Latimeria chalumnae ENSLACG00000011545 I 0.867
RUNX2 Gorilla gorilla ENSGGOG00000012890 I 0.867
RUNX3 Myotis lucifugus ENSMLUG00000003395 I 0.867
Runx2 Mus musculus ENSMUSG00000039153 D 0.867
RUNX2 Otolemur garnettii ENSOGAG00000003900 I 0.867
ENSSTOG00000010163 Ictidomys tridecemlineatus ENSSTOG00000010163 I 0.867
RUNX2 Ochotona princeps ENSOPRG00000002943 I 0.867
RUNX2 Dasypus novemcinctus ENSDNOG00000034361 I 0.867
ENSPPYG00000016664 Pongo abelii ENSPPYG00000016664 I 0.867
RUNX2 Macaca mulatta ENSMMUG00000019819 I 0.867
ENSCSAG00000012528 Chlorocebus sabaeus ENSCSAG00000012528 I 0.867
ENSPANG00000006186 Papio anubis ENSPANG00000006186 I 0.867
RUNX2 Cavia porcellus ENSCPOG00000005277 I 0.867
RUNX2 Pan troglodytes ENSPTRG00000018228 I 0.867
RUNX2 Erinaceus europaeus ENSEEUG00000009243 I 0.867
RUNX2 Equus caballus ENSECAG00000020875 I 0.867
Pvit_01165 Pogona vitticeps Pvit_01165 I 0.857
ENSAMXG00000004048 Astyanax mexicanus ENSAMXG00000004048 I 0.857
runx3 Takifugu rubripes ENSTRUG00000001517 I 0.857
ENSMPUG00000012508 Mustela putorius furo ENSMPUG00000012508 I 0.857
RUNX2 Taeniopygia guttata ENSTGUG00000013249 I 0.857
runx3 Tetraodon nigroviridis ENSTNIG00000016911 I 0.857
ENSSHAG00000012559 Sarcophilus harrisii ENSSHAG00000012559 I 0.857
runx3 Gasterosteus aculeatus ENSGACG00000007301 I 0.857
RUNX3 Bos taurus ENSBTAG00000019800 I 0.857
Cmyd_10020455 Chelonia mydas Cmyd_10020455 I 0.857
ENSONIG00000008210 Oreochromis niloticus ENSONIG00000008210 I 0.857
runx3 Danio rerio ENSDARG00000052826 I 0.857
runx3 Oryzias latipes ENSORLG00000017515 I 0.857
ENSOARG00000006421 Ovis aries ENSOARG00000006421 I 0.857
RUNX2 Anolis carolinensis ENSACAG00000013003 I 0.857
ENSXMAG00000018835 Xiphophorus maculatus ENSXMAG00000018835 I 0.857
Aan_R005895 Calypte anna Aan_R005895 I 0.857
ENSAMXG00000017349 Astyanax mexicanus ENSAMXG00000017349 I 0.857
ENSNLEG00000009021 Nomascus leucogenys ENSNLEG00000009021 I 0.857
ENSPFOG00000003997 Poecilia formosa ENSPFOG00000003997 I 0.857
ENSCING00000002253 Ciona intestinalis ENSCING00000002253 I 0.853
ENSNLEG00000003611 Nomascus leucogenys ENSNLEG00000003611 I 0.848
ENSLOCG00000002744 Lepisosteus oculatus ENSLOCG00000002744 I 0.848
RUNX2 Loxodonta africana ENSLAFG00000005054 I 0.848
runx2b Gasterosteus aculeatus ENSGACG00000012322 I 0.848
ENSAMXG00000000881 Astyanax mexicanus ENSAMXG00000000881 I 0.848
ENSFALG00000001493 Ficedula albicollis ENSFALG00000001493 I 0.848
Gfo_R000714 Geospiza fortis Gfo_R000714 I 0.848
RUNX2 Tupaia belangeri ENSTBEG00000000948 I 0.838
ENSP00000300305 Macaca fascicularis ENSP00000300305 I 0.838
RUNX2 Felis catus ENSFCAG00000022480 I 0.838
ENSBTAP00000006227-D1 Bos grunniens ENSBTAP00000006227-D1 I 0.838
RUNX2 Ornithorhynchus anatinus ENSOANG00000008265 I 0.838
ENSOCUG00000011739 Oryctolagus cuniculus ENSOCUG00000011739 I 0.838
runx2 Takifugu rubripes ENSTRUG00000003501 I 0.838
runx2.L Xenopus laevis XB-GENE-864817 I 0.838
ENSGALG00000026484 Gallus gallus ENSGALG00000026484 I 0.838
RUNX2 Myotis lucifugus ENSMLUG00000000514 I 0.838
XP_002939387 Xenopus tropicalis XP_002939387 I 0.829
Pvit_04762 Pogona vitticeps Pvit_04762 I 0.829
ENSPPYG00000011394 Pongo abelii ENSPPYG00000011394 I 0.829
Ogr17914 Ophisaurus gracilis Ogr17914 I 0.829
XP_002939386 Xenopus tropicalis XP_002939386 I 0.829
ENSP00000409227-D1 Bos grunniens ENSP00000409227-D1 I 0.829
RUNX1 Pan troglodytes ENSPTRG00000013883 I 0.829
Runx1 Rattus norvegicus ENSRNOG00000001704 I 0.829
ENSSHAG00000014782 Sarcophilus harrisii ENSSHAG00000014782 I 0.829
runx2 Xenopus tropicalis XB-GENE-482021 I 0.829
ENSSSCG00000012051 Sus scrofa ENSSSCG00000012051 I 0.829
RUNX1 Pteropus vampyrus ENSPVAG00000001606 I 0.829
Alligator_sinensis_CCG001676.1 Alligator sinensis Alligator_sinensis_CCG001676.1 I 0.829
Cmyd_10021516 Chelonia mydas Cmyd_10021516 I 0.829
ENSPSIG00000017547 Pelodiscus sinensis ENSPSIG00000017547 I 0.829
RUNX1 Otolemur garnettii ENSOGAG00000033362 I 0.829
Runx1 Mus musculus ENSMUSG00000022952 D 0.829
RUNX1 Loxodonta africana ENSLAFG00000004290 I 0.829
ENSNLEG00000004310 Nomascus leucogenys ENSNLEG00000004310 I 0.829
ENSOARG00000013599 Ovis aries ENSOARG00000013599 I 0.829
ENSCSAG00000008703 Chlorocebus sabaeus ENSCSAG00000008703 I 0.829
RUNX1 Bos taurus ENSBTAG00000004742 I 0.829
RUNX1 Microcebus murinus ENSMICG00000011998 I 0.829
RUNX1 Macaca mulatta ENSMMUG00000001649 I 0.829
ENSFALG00000000025 Ficedula albicollis ENSFALG00000000025 I 0.829
RUNX1 Monodelphis domestica ENSMODG00000021051 I 0.829
RUNX1 Gallus gallus ENSGALG00000016022 I 0.829
RUNX1 Oryctolagus cuniculus ENSOCUG00000013731 I 0.829
RUNX1 Callithrix jacchus ENSCJAG00000002816 I 0.829
ENSOPRG00000000765 Ochotona princeps ENSOPRG00000000765 I 0.829
ENSPANG00000007357 Papio anubis ENSPANG00000007357 I 0.829
Runx1 Dipodomys ordii ENSDORG00000004347 I 0.829
RUNX1 Canis familiaris ENSCAFG00000009596 I 0.829
ENSAMEG00000005325 Ailuropoda melanoleuca ENSAMEG00000005325 I 0.829
RUNX1 Homo sapiens ENSG00000159216 D 0.829
RUNX1 Gorilla gorilla ENSGGOG00000012862 I 0.829
RUNX1 Dasypus novemcinctus ENSDNOG00000015041 I 0.819
ENSCPOG00000002684 Cavia porcellus ENSCPOG00000002684 I 0.819
RUNX1 Equus caballus ENSECAG00000003462 I 0.819
ENSMPUG00000001340 Mustela putorius furo ENSMPUG00000001340 I 0.819
XP_002939388 Xenopus tropicalis XP_002939388 I 0.810
ENSLACG00000013776 Latimeria chalumnae ENSLACG00000013776 I 0.810
runx1.L Xenopus laevis XB-GENE-864949 I 0.810
ENSONIG00000004914 Oreochromis niloticus ENSONIG00000004914 I 0.800
Afo_R012718 Aptenodytes forsteri Afo_R012718 I 0.800
Afo_R008955 Aptenodytes forsteri Afo_R008955 I 0.800
RUNX1 Gasterosteus aculeatus ENSGACG00000015276 I 0.800
ENSAMXG00000012244 Astyanax mexicanus ENSAMXG00000012244 I 0.800
ENSTSYG00000005097 Tarsius syrichta ENSTSYG00000005097 I 0.800
ENSTNIG00000018690 Tetraodon nigroviridis ENSTNIG00000018690 I 0.800
RUNX1 Tursiops truncatus ENSTTRG00000014160 I 0.800
ENSMGAG00000014534 Meleagris gallopavo ENSMGAG00000014534 I 0.790
runx1 Takifugu rubripes ENSTRUG00000012611 I 0.790
Aan_R002212 Calypte anna Aan_R002212 I 0.788
ENSGMOG00000014088 Gadus morhua ENSGMOG00000014088 I 0.781
ENSLACG00000015930 Latimeria chalumnae ENSLACG00000015930 I 0.781
Gfo_R011596 Geospiza fortis Gfo_R011596 I 0.769
Sakowv30005496m.g Saccoglossus kowalevskii Sakowv30005496m.g I 0.752
TC005566 Tribolium castaneum TC005566 I 0.743
ACEP16400 Atta cephalotes ACEP16400 I 0.738
ASTEI07771 Anopheles stephensi ASTEI07771 I 0.733
AATE002063 Anopheles atroparvus AATE002063 I 0.733
XP_002165633.1 Hydra magnipapillata XP_002165633.1 I 0.733
AAEL006160 Aedes aegypti AAEL006160 I 0.733
Cflo_03911--XP_394014.2_APIME Camponotus floridanus Cflo_03911--XP_394014.2_APIME I 0.724
YQE_12218 Dendroctonus ponderosae YQE_12218 I 0.724
TC006536 Tribolium castaneum TC006536 I 0.724
NV11000 Nasonia vitripennis NV11000 I 0.724
Runx3 Mus musculus ENSMUSG00000070691 D 0.715
RUNX3 Tursiops truncatus ENSTTRG00000009396 I 0.715
ENSAMEG00000010102 Ailuropoda melanoleuca ENSAMEG00000010102 I 0.715
ENSSTOG00000022471 Ictidomys tridecemlineatus ENSSTOG00000022471 I 0.715
Runx3 Rattus norvegicus ENSRNOG00000054217 I 0.715
RUNX3 Ochotona princeps ENSOPRG00000011273 I 0.715
RUNX3 Pan troglodytes ENSPTRG00000000351 I 0.715
RUNX3 Otolemur garnettii ENSOGAG00000025633 I 0.715
RUNX3 Oryctolagus cuniculus ENSOCUG00000017751 I 0.715
RUNX3 Canis familiaris ENSCAFG00000012903 I 0.715
ENSCPOG00000000551 Cavia porcellus ENSCPOG00000000551 I 0.715
RUNX3 Gorilla gorilla ENSGGOG00000004848 I 0.715
RUNX3 Felis catus ENSFCAG00000000680 I 0.715
RUNX3 Homo sapiens ENSG00000020633 D 0.715
ENSPANG00000008140 Papio anubis ENSPANG00000008140 I 0.715
ENSCSAG00000000947 Chlorocebus sabaeus ENSCSAG00000000947 I 0.715
LLOJ002717 Lutzomyia longipalpis LLOJ002717 I 0.714
RPRC005391 Rhodnius prolixus RPRC005391 I 0.714
MCINX000302 Melitaea cinxia MCINX000302 I 0.714
tetur01g02340 Tetranychus urticae tetur01g02340 I 0.714
ENSPSIG00000012728 Pelodiscus sinensis ENSPSIG00000012728 I 0.708
RUNX3 Macaca mulatta ENSMMUG00000002420 I 0.708
PPAI006591 Phlebotomus papatasi PPAI006591 I 0.708
ENSONIG00000001436 Oreochromis niloticus ENSONIG00000001436 I 0.705
Cflo_03909--XP_394016.2_APIME Camponotus floridanus Cflo_03909--XP_394016.2_APIME I 0.705
SINV13317 Solenopsis invicta SINV13317 I 0.705
Hsal_12319--XP_394016.2_APIME Harpegnathos saltator Hsal_12319--XP_394016.2_APIME I 0.705
Alligator_sinensis_CCG010991.1 Alligator sinensis Alligator_sinensis_CCG010991.1 I 0.705
GK25373 Drosophila willistoni FBgn0227332 I 0.705
TC005796 Tribolium castaneum TC005796 I 0.705
MESCA007078 Megaselia scalaris MESCA007078 I 0.703
runx3.L Xenopus laevis XB-GENE-6487158 I 0.700
Myotis_brandtii_RUNX2_10026084 Myotis brandtii Myotis_brandtii_RUNX2_10026084 I 0.700
AALB007752 Anopheles albimanus AALB007752 I 0.700