SP140 (Homo sapiens)
SAND

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF01342 (SAND) IPR000770 ENSG00000079263 T321710_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000342096 SAND 524 600
ENSP00000375899 SAND 584 660
ENSP00000393618 SAND 470 546
ENSP00000398210 SAND 557 633

Links

Other SAND family TFs
Other Homo sapiens TFs

27 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
SP140 Pan troglodytes ENSPTRG00000013010 N 0.994
SP140 Gorilla gorilla ENSGGOG00000006936 N 0.994
ENSPPYG00000013253 Pongo abelii ENSPPYG00000013253 N 0.992
ENSNLEG00000013760 Nomascus leucogenys ENSNLEG00000013760 N 0.992
SP140 Callithrix jacchus ENSCJAG00000013289 N 0.987
ENSMMUP00000015997 Macaca fascicularis ENSMMUP00000015997 N 0.986
ENSCSAG00000006962 Chlorocebus sabaeus ENSCSAG00000006962 N 0.986
SP140 Macaca mulatta ENSMMUG00000012199 N 0.986
SP140L Gorilla gorilla ENSGGOG00000002900 N 0.977
SP140L Homo sapiens ENSG00000185404 N 0.970
SP140L Pan troglodytes ENSPTRG00000013011 N 0.963
ENSCAFG00000010704 Canis familiaris ENSCAFG00000010704 N 0.932
ENSFCAG00000002520 Felis catus ENSFCAG00000002520 N 0.924
SP140L Callithrix jacchus ENSCJAG00000035676 N 0.924
SP100 Macaca mulatta ENSMMUG00000016575 N 0.919
ENSCSAG00000006889 Chlorocebus sabaeus ENSCSAG00000006889 N 0.919
ENSLAFG00000002303 Loxodonta africana ENSLAFG00000002303 N 0.913
ENSECAG00000022252 Equus caballus ENSECAG00000022252 N 0.913
ENSPCAG00000005793 Procavia capensis ENSPCAG00000005793 N 0.912
ENSAMEG00000016495 Ailuropoda melanoleuca ENSAMEG00000016495 N 0.912
ENSMPUG00000004415 Mustela putorius furo ENSMPUG00000004415 N 0.898
ENSOARG00000020646 Ovis aries ENSOARG00000020646 N 0.875
ENSETEG00000017626 Echinops telfairi ENSETEG00000017626 N 0.872
SP140 Tursiops truncatus ENSTTRG00000009293 N 0.859
ENSMICG00000015716 Microcebus murinus ENSMICG00000015716 N 0.848
ENSSTOG00000005247 Ictidomys tridecemlineatus ENSSTOG00000005247 N 0.845