CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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smad3b
(
Danio rerio
)
SMAD
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF03165 (MH1)
IPR003619
ENSDARG00000010207
T324553_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including cell differentiation; regulation of transcription by RNA polymerase II; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in several structures, including immature eye; lateral mesoderm; margin; nervous system; and tail bud. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic cancer. Orthologous to human SMAD3 (SMAD family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Smad3
M00192_2.00
Mus musculus
NNNNNMGMCN
NGKCKNNNNN
PBM
Badis et al.(2009)
Smad3_3805
0.921
0.921
SMAD3
M03482_2.00
Homo sapiens
YGTCTAGACA
TGTCTAGACR
SELEX
Jolma et al.(2013)
SMAD3_1
0.921
0.921
SMAD3
M09380_2.00
Homo sapiens
NBCTSHCWSCWB
VWGSWGDSAGVN
Misc
Kulakovskiy et al.(2013)
SMAD3_HUMAN.H11MO.0.B
0.921
0.921
Smad3
M09384_2.00
Mus musculus
NBCTSHCWSCWB
VWGSWGDSAGVN
Misc
Kulakovskiy et al.(2013)
SMAD3_MOUSE.H11MO.0.B
0.921
0.921
Smad3
M09637_2.00
Mus musculus
BYAGMCWN
NWGKCTRV
Misc
Heinz et al.(2010)
NPC-Smad3_GSE36673
0.921
0.921
SMAD3
M11283_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD3_Q6_01
0.921
0.921
SMAD3
M11284_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD3_Q6_02
0.921
0.921
SMAD3
M11285_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD3_Q6
0.921
0.921
SMAD1
M11286_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD1_01
0.713
0.713
SMAD1
M11287_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD1_Q6
0.713
0.713
Smad5
M11288_2.00
Mus musculus
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD5_01
0.713
0.713
Smad5
M11292_2.00
Rattus norvegicus
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD5_03
0.713
0.713
SMAD9
M11274_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD8_01
0.713
0.713
Smad9
M11290_2.00
Rattus norvegicus
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD8_02
0.713
0.713
Smad9
M11289_2.00
Mus musculus
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD8_03
0.713
0.713
Mad
M06446_2.00
Drosophila melanogaster
GYGHCGBCVS
SBGVCGDCRC
B1H
Zhu et al.(2011)
Mad_FlyReg_FBgn0011648
0.703
0.703
Mad
M08427_2.00
Drosophila melanogaster
SNGRCGMSRVSRBNS
SNVYSBYSKCGYCNS
ChIP-chip
Mathelier et al.(2014)
MA0535.1
0.703
0.703
Mad
M09692_2.00
Drosophila melanogaster
KCBGSHGKCGCSNC
GNSGCGMCDSCVGM
Misc
Kulakovskiy et al.(2009)
Mad
0.703
0.703
Mad
M11293_2.00
Drosophila melanogaster
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
I$MAD_Q6
0.703
0.703
For this family, TFs with SR scores >
0.700
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSDARP00000043454
SMAD
30
130
CEKAVKSLVKKLKKTGQLEELEKAITTQNINTKCITIPRSLDGRLQVSHKKGLPHVIYCRLWRWPDLQSHHELRAVEMCEFAFHTKKDEVCVNPYHYQRVE
Links
Other
SMAD
family TFs
Other
Danio rerio
TFs
390 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy