NFIX (Homo sapiens)
SMAD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF03165 (MH1) IPR003619 ENSG00000008441 T324622_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
NFIX
M03475_2.00		 Homo sapiens
YTGGCNNNNTGCCAA
TTGGCANNNNGCCAR		 SELEX
Jolma et al.(2013)
NFIX_1		 (Direct) (Direct)
NFIX
M03476_2.00		 Homo sapiens
NYTGGCDNN
NNHGCCARN		 SELEX
Jolma et al.(2013)
NFIX_2		 (Direct) (Direct)
NFIX
M03477_2.00		 Homo sapiens
NYTGGCWNN
NNWGCCARN		 SELEX
Jolma et al.(2013)
NFIX_3		 (Direct) (Direct)
NFIX
M03478_2.00		 Homo sapiens
TTGGCANNNTGCCAR
YTGGCANNNTGCCAA		 SELEX
Jolma et al.(2013)
NFIX_4		 (Direct) (Direct)
NFIX
M05741_2.00		 Homo sapiens
NHTGGCDNNNTGCCADN
NHTGGCANNNHGCCADN		 SELEX
Yin et al.(2017)
NFIX_FL_HT-SELEX		 (Direct) (Direct)
NFIX
M05742_2.00		 Homo sapiens
NYTGGCDNNNTGCCARN
NYTGGCANNNHGCCARN		 SELEX
Yin et al.(2017)
NFIX_FL_Methyl-HT-SELEX		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
NFIA
M03480_2.00 		Homo sapiens
YTGGCANNNTGCCAA
TTGGCANNNTGCCAR		 SELEX
Jolma et al.(2013)
NFIA_1 		0.934 0.934
NFIA
M03481_2.00 		Homo sapiens
NNTGCCAANN
NNTTGGCANN		 SELEX
Jolma et al.(2013)
NFIA_2 		0.934 0.934
NFIA
M09379_2.00 		Homo sapiens
YTGGCWNYNDGCCAD
HTGGCHNRNWGCCAR		 Misc
Kulakovskiy et al.(2013)
NFIA_HUMAN.H11MO.0.C 		0.953 0.953
Nfia
M09383_2.00 		Mus musculus
YTGGCWNYNDGCCAD
HTGGCHNRNWGCCAR		 Misc
Kulakovskiy et al.(2013)
NFIA_MOUSE.H11MO.0.C 		0.953 0.953
NFIA
M11282_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NF1A_Q6_01 		0.953 0.953
Nfia
M11291_2.00 		Rattus norvegicus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NFIA_02 		0.953 0.953
NFIB
M03479_2.00 		Homo sapiens
YTGGCANNNTGCCAA
TTGGCANNNTGCCAR		 SELEX
Jolma et al.(2013)
NFIB_1 		0.930 0.930
NFIB
M05747_2.00 		Homo sapiens
NYTGGCNNNNYGCCARN
NYTGGCRNNNNGCCARN		 SELEX
Yin et al.(2017)
NFIB_FL_HT-SELEX 		0.930 0.930
Nfib
M09381_2.00 		Mus musculus
BVWGCCARV
BYTGGCWBV		 Misc
Kulakovskiy et al.(2013)
NFIB_MOUSE.H11MO.0.C 		0.901 0.901
NFIB
M11280_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NF1B_Q6_01 		0.901 0.901
NFIB
M11281_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NF1B_Q6 		0.930 0.930
NFIB
M05748_2.00 		Homo sapiens
NTTGGCDNNNTGCCARN
NYTGGCANNNHGCCAAN		 SELEX
Yin et al.(2017)
NFIB_FL_Methyl-HT-SELEX 		0.930 0.930
NFIC
M05745_2.00 		Homo sapiens
NTTGGCNNNNTGCCARN
NYTGGCANNNNGCCAAN		 SELEX
Yin et al.(2017)
NFIC_FL_HT-SELEX 		0.849 0.849
NFIC
M08164_2.00 		Homo sapiens
NNCTTGGCANN
NNTGCCAAGNN		 ChIP-seq
Mathelier et al.(2014)
MA0161.2 		0.849 0.849
NFIC
M09378_2.00 		Homo sapiens
BYTGGMHBYNDKCCMRV
BYKGGMHNRVDKCCARV		 Misc
Kulakovskiy et al.(2013)
NFIC_HUMAN.H11MO.0.A 		0.849 0.849
NFIC
M09635_2.00 		Homo sapiens
BYTGSCAV
BTGSCARV		 Misc
Heinz et al.(2010)
LNCaP-NF1_Unpublished 		0.849 0.849
NFIC
M09636_2.00 		Homo sapiens
BYTGGCHNNNDGCCAR
YTGGCHNNNDGCCARV		 Misc
Heinz et al.(2010)
LNCAP-NF1_Unpublished 		0.835 0.835
NFIC
M11278_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$CTF1_01 		0.835 0.835
NFIC
M11279_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NF1C_Q6 		0.849 0.849
NFIC
M05746_2.00 		Homo sapiens
NYTGGCNNNNYGCCARN
NYTGGCRNNNNGCCARN		 SELEX
Yin et al.(2017)
NFIC_FL_Methyl-HT-SELEX 		0.849 0.849
Nfic
M09385_2.00 		Mus musculus
NBYTGGCWN
NWGCCARVN		 Misc
Kulakovskiy et al.(2013)
NFIC_MOUSE.H11MO.0.A 		0.837 0.837
NfI
M03968_2.00 		Drosophila melanogaster
YTGGCDNNNHGCCAR
YTGGCDNNNHGCCAR		 SELEX
Nitta et al.(2015)
NfI_1 		0.779 0.779
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000351354 SMAD 71 175
ENSP00000353219 SMAD 71 175
ENSP00000380781 SMAD 68 172
ENSP00000465094 SMAD 84 183
ENSP00000465616 SMAD 21 125
ENSP00000466389 SMAD 60 164
ENSP00000466605 SMAD 21 100
ENSP00000466735 SMAD 21 125
ENSP00000467512 SMAD 68 172
ENSP00000467785 SMAD 67 171
ENSP00000468707 SMAD 21 125
ENSP00000468794 SMAD 60 164

Links

Other SMAD family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

360 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action