SMAD4 (Homo sapiens)
SMAD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF03165 (MH1) IPR003619 ENSG00000141646 T324625_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasing blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, May 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
SMAD4
M09377_2.00		 Homo sapiens
DRGTGNSAGACWN
NWGTCTSNCACYH		 Misc
Kulakovskiy et al.(2013)
SMAD4_HUMAN.H11MO.0.B		 (Direct) (Direct)
SMAD4
M09634_2.00		 Homo sapiens
NNNYGTCTGS
SCAGACRNNN		 Misc
Heinz et al.(2010)
ESC-SMAD4_GSE29422		 (Direct) (Direct)
SMAD4
M11275_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD4_Q4		 (Direct) (Direct)
SMAD4
M11276_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD4_Q6_01		 (Direct) (Direct)
SMAD4
M11277_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD4_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Smad4
M05889_2.00 		Mus musculus
KCYAGACR
YGTCTRGM		 SMiLE-seq
Isakova et al.(2017)
Smad4 		1.000 1.000
Smad4
M09382_2.00 		Mus musculus
DGWGNBAGVCWN
NWGBCTVNCWCH		 Misc
Kulakovskiy et al.(2013)
SMAD4_MOUSE.H11MO.0.A 		1.000 1.000
Med
M06447_2.00 		Drosophila melanogaster
KCGBCDKKSHVT
ABDSMMHGVCGM		 B1H
Zhu et al.(2011)
Med_FlyReg_FBgn0011655 		0.953 0.953
Med
M09693_2.00 		Drosophila melanogaster
YYBYVYCTGYY
RRCAGRBRVRR		 Misc
Kulakovskiy et al.(2009)
Med 		0.961 0.961
sma-4
M02484_2.00 		Caenorhabditis elegans
NNCCAGACANN
NNTGTCTGGNN		 PBM
Weirauch et al.(2014)
pTH8996 		0.727 0.727
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000341551 SMAD 36 137
ENSP00000381452 SMAD 36 137
ENSP00000464772 SMAD 36 137
ENSP00000464901 SMAD 36 137
ENSP00000465874 SMAD 36 120
ENSP00000465878 SMAD 36 126
ENSP00000466934 SMAD 36 90
ENSP00000466941 SMAD 36 137
ENSP00000468611 SMAD 36 137

Links

Other SMAD family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

239 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action