SMAD4 (Homo sapiens)
SMAD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF03165 (MH1) IPR003619 ENSG00000141646 T324625_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasng blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Aug 2017]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
SMAD4
M09377_2.00
Homo sapiens
DRGTGNSAGACWN

NWGTCTSNCACYH
Misc
Kulakovskiy et al.(2013)
SMAD4_HUMAN.H11MO.0.B
(Direct) (Direct)
SMAD4
M09634_2.00
Homo sapiens
NNNYGTCTGS

SCAGACRNNN
Misc
Heinz et al.(2010)
ESC-SMAD4_GSE29422
(Direct) (Direct)
SMAD4
M11275_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD4_Q4
(Direct) (Direct)
SMAD4
M11276_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD4_Q6_01
(Direct) (Direct)
SMAD4
M11277_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD4_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Smad4
M05889_2.00
Mus musculus
KCYAGACR

YGTCTRGM
SMiLE-seq
Isakova et al.(2017)
Smad4
1.000 1.000
Smad4
M09382_2.00
Mus musculus
DGWGNBAGVCWN

NWGBCTVNCWCH
Misc
Kulakovskiy et al.(2013)
SMAD4_MOUSE.H11MO.0.A
1.000 1.000
Med
M06447_2.00
Drosophila melanogaster
KCGBCDKKSHVT

ABDSMMHGVCGM
B1H
Zhu et al.(2011)
Med_FlyReg_FBgn0011655
0.982 0.982
Med
M09693_2.00
Drosophila melanogaster
YYBYVYCTGYY

RRCAGRBRVRR
Misc
Kulakovskiy et al.(2009)
Med
0.982 0.982
sma-4
M02484_2.00
Caenorhabditis elegans
NNCCAGACANN

NNTGTCTGGNN
PBM
Weirauch et al.(2014)
pTH8996
0.727 0.727
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000341551 SMAD 36 137
ENSP00000381452 SMAD 36 137
ENSP00000464772 SMAD 36 137
ENSP00000464901 SMAD 36 137
ENSP00000465874 SMAD 36 120
ENSP00000465878 SMAD 36 126
ENSP00000466934 SMAD 36 90
ENSP00000466941 SMAD 36 137
ENSP00000468611 SMAD 36 137

Links

Other SMAD family TFs
Other Homo sapiens TFs

239 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
A1O1_07182 Capronia coronata A1O1_07182 N 0.000
CFIO01_03814 Colletotrichum fioriniae CFIO01_03814 N 0.000
CSUB01_02732 Colletotrichum sublineola CSUB01_02732 N 0.000
GLRG_09914 Colletotrichum graminicola GLRG_09914 N 0.000
NechaG53241 Fusarium solani NechaG53241 N 0.000
PV05_11114 Exophiala xenobiotica PV05_11114 N 0.000
UCREL1_5869 Eutypa lata UCREL1_5869 N 0.000
Z518_00258 Rhinocladiella mackenziei Z518_00258 N 0.000
e_gw1.56.87.1 Nectria haematococca e_gw1.56.87.1 N 0.000