SMAD1 (Homo sapiens)
SMAD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF03165 (MH1) IPR003619 ENSG00000170365 T324630_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
SMAD1
M11286_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD1_01		 (Direct) (Direct)
SMAD1
M11287_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD1_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Smad5
M11288_2.00 		Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD5_01 		0.952 0.952
SMAD5
M05743_2.00 		Homo sapiens
YGTCTAGACW
WGTCTAGACR		 SELEX
Yin et al.(2017)
SMAD5_eDBD_HT-SELEX 		0.966 0.966
Smad5
M11292_2.00 		Rattus norvegicus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD5_03 		0.974 0.974
SMAD9
M11274_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD8_01 		0.948 0.948
SMAD5
M11271_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD5_02 		0.966 0.966
Smad9
M11290_2.00 		Rattus norvegicus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD8_02 		0.948 0.948
Smad9
M11289_2.00 		Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD8_03 		0.948 0.948
SMAD5
M11272_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD5_Q5_01 		0.966 0.966
SMAD5
M11273_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD5_Q5 		0.966 0.966
Mad
M06446_2.00 		Drosophila melanogaster
GYGHCGBCVS
SBGVCGDCRC		 B1H
Zhu et al.(2011)
Mad_FlyReg_FBgn0011648 		0.935 0.935
Mad
M08427_2.00 		Drosophila melanogaster
SNGRCGMSRVSRBNS
SNVYSBYSKCGYCNS		 ChIP-chip
Mathelier et al.(2014)
MA0535.1 		0.902 0.902
SMAD5
M05744_2.00 		Homo sapiens
CGTCTAGACR
YGTCTAGACG		 SELEX
Yin et al.(2017)
SMAD5_eDBD_Methyl-HT-SELEX 		0.966 0.966
Mad
M09692_2.00 		Drosophila melanogaster
KCBGSHGKCGCSNC
GNSGCGMCDSCVGM		 Misc
Kulakovskiy et al.(2009)
Mad 		0.924 0.924
Mad
M11293_2.00 		Drosophila melanogaster Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
I$MAD_Q6 		0.904 0.904
Smad3
M00192_2.00 		Mus musculus
NNNNNMGMCN
NGKCKNNNNN		 PBM
Badis et al.(2009)
Smad3_3805 		0.701 0.701
SMAD3
M03482_2.00 		Homo sapiens
YGTCTAGACA
TGTCTAGACR		 SELEX
Jolma et al.(2013)
SMAD3_1 		0.701 0.701
SMAD3
M09380_2.00 		Homo sapiens
NBCTSHCWSCWB
VWGSWGDSAGVN		 Misc
Kulakovskiy et al.(2013)
SMAD3_HUMAN.H11MO.0.B 		0.701 0.701
Smad3
M09384_2.00 		Mus musculus
NBCTSHCWSCWB
VWGSWGDSAGVN		 Misc
Kulakovskiy et al.(2013)
SMAD3_MOUSE.H11MO.0.B 		0.701 0.701
Smad3
M09637_2.00 		Mus musculus
BYAGMCWN
NWGKCTRV		 Misc
Heinz et al.(2010)
NPC-Smad3_GSE36673 		0.701 0.701
SMAD3
M11283_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD3_Q6_01 		0.701 0.701
SMAD3
M11284_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD3_Q6_02 		0.701 0.701
SMAD3
M11285_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD3_Q6 		0.701 0.701
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000305769 SMAD 30 131
ENSP00000377652 SMAD 30 131
ENSP00000422706 SMAD 30 58
ENSP00000424649 SMAD 30 95
ENSP00000424959 SMAD 30 106
ENSP00000425270 SMAD 30 112
ENSP00000426568 SMAD 30 131
ENSP00000427002 SMAD 30 131

Links

Other SMAD family TFs
Other Homo sapiens TFs

462 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
SMAD1 Otolemur garnettii ENSOGAG00000000150 I 1.000
SMAD1 Canis familiaris ENSCAFG00000007659 I 1.000
ENSMPUG00000006867 Mustela putorius furo ENSMPUG00000006867 I 1.000
SMAD1 Pteropus vampyrus ENSPVAG00000014298 I 1.000
ENSSHAG00000006387 Sarcophilus harrisii ENSSHAG00000006387 I 1.000
SMAD1 Dasypus novemcinctus ENSDNOG00000048112 I 1.000
SMAD1 Bos taurus ENSBTAG00000002835 I 1.000
SMAD1 Pan troglodytes ENSPTRG00000016485 I 1.000
SMAD1 Equus caballus ENSECAG00000022649 I 1.000
ENSNLEG00000005537 Nomascus leucogenys ENSNLEG00000005537 I 1.000
Myotis_brandtii_SMAD1_10016918 Myotis brandtii Myotis_brandtii_SMAD1_10016918 I 1.000
ENSAPLG00000012107 Anas platyrhynchos ENSAPLG00000012107 I 1.000
Pvit_02496 Pogona vitticeps Pvit_02496 I 1.000
SMAD1 Callithrix jacchus ENSCJAG00000002542 I 1.000
ENSOARG00000009089 Ovis aries ENSOARG00000009089 I 1.000
Tal_R004006 Tyto alba Tal_R004006 I 1.000
SMAD1 Echinops telfairi ENSETEG00000016533 I 1.000
Smad1 Rattus norvegicus ENSRNOG00000018483 I 1.000
SMAD1 Erinaceus europaeus ENSEEUG00000008384 I 1.000
Brh_R002100 Buceros rhinoceros Brh_R002100 I 1.000
Smad1 Mus musculus ENSMUSG00000031681 I 1.000
SMAD1 Cavia porcellus ENSCPOG00000009073 I 1.000
SMAD1 Felis catus ENSFCAG00000004136 I 1.000
Ogr00592 Ophisaurus gracilis Ogr00592 I 1.000
ENSCSAG00000003430 Chlorocebus sabaeus ENSCSAG00000003430 I 1.000
ENSFALG00000005536 Ficedula albicollis ENSFALG00000005536 I 1.000
Alligator_sinensis_CCG006386.1 Alligator sinensis Alligator_sinensis_CCG006386.1 I 1.000
SMAD1 Ornithorhynchus anatinus ENSOANG00000006538 I 1.000
ENSLACG00000011249 Latimeria chalumnae ENSLACG00000011249 I 1.000
SMAD1 Loxodonta africana ENSLAFG00000018345 I 1.000
ENSBTAP00000003668-D1 Bos grunniens ENSBTAP00000003668-D1 I 1.000
ENSPSIG00000016396 Pelodiscus sinensis ENSPSIG00000016396 I 1.000
SMAD1 Macaca mulatta ENSMMUG00000018384 I 1.000
SMAD1 Taeniopygia guttata ENSTGUG00000002675 I 1.000
SMAD1 Myotis lucifugus ENSMLUG00000012261 I 1.000
ENSLOCG00000008877 Lepisosteus oculatus ENSLOCG00000008877 I 1.000
SMAD1 Meleagris gallopavo ENSMGAG00000003725 I 1.000
SMAD1 Tursiops truncatus ENSTTRG00000008086 I 1.000
ENSP00000377652 Macaca fascicularis ENSP00000377652 I 1.000
ENSTSYG00000000913 Tarsius syrichta ENSTSYG00000000913 I 1.000
Aan_R003078 Calypte anna Aan_R003078 I 1.000
SMAD1 Gallus gallus ENSGALG00000009977 I 1.000
smad1.S Xenopus laevis XB-GENE-6253892 I 1.000
ENSPANG00000016688 Papio anubis ENSPANG00000016688 I 1.000
SMAD1 Tupaia belangeri ENSTBEG00000016459 I 1.000
ENSAMEG00000016645 Ailuropoda melanoleuca ENSAMEG00000016645 I 1.000
ENSGGOG00000022121 Gorilla gorilla ENSGGOG00000022121 I 1.000
Cmyd_10015900 Chelonia mydas Cmyd_10015900 I 1.000
SMAD1 Anolis carolinensis ENSACAG00000003544 I 1.000
Afo_R005797 Aptenodytes forsteri Afo_R005797 I 1.000
Gfo_R000868 Geospiza fortis Gfo_R000868 I 1.000
SMAD1 Monodelphis domestica ENSMODG00000000500 I 1.000
SMAD1 Microcebus murinus ENSMICG00000000562 I 0.990
smad1 Xenopus tropicalis XB-GENE-1018193 I 0.990
smad1.L Xenopus laevis XB-GENE-1018199 I 0.990
SMAD1 Oryctolagus cuniculus ENSOCUG00000017920 I 0.990
SMAD1 Choloepus hoffmanni ENSCHOG00000009259 I 0.990
smad1 Danio rerio ENSDARG00000027199 I 0.976
smad5 Gasterosteus aculeatus ENSGACG00000018718 I 0.974
ENSPFOG00000024550 Poecilia formosa ENSPFOG00000024550 I 0.974
smad1 Gasterosteus aculeatus ENSGACG00000017230 I 0.974
SMAD5 Homo sapiens ENSG00000113658 D 0.974
SMAD5 Ornithorhynchus anatinus ENSOANG00000009906 I 0.974
ENSXMAG00000009618 Xiphophorus maculatus ENSXMAG00000009618 I 0.974
ENSPFOG00000005752 Poecilia formosa ENSPFOG00000005752 I 0.974
estExt_fgenesh2_pm.C_1880004 Branchiostoma floridae estExt_fgenesh2_pm.C_1880004 I 0.974
ENSONIG00000010000 Oreochromis niloticus ENSONIG00000010000 I 0.974
SMAD5 Ochotona princeps ENSOPRG00000010102 I 0.974
ENSXMAG00000016280 Xiphophorus maculatus ENSXMAG00000016280 I 0.974
smad1 Tetraodon nigroviridis ENSTNIG00000017720 I 0.974
smad1 Takifugu rubripes ENSTRUG00000014344 I 0.974
estExt_fgenesh2_pg.C_20279 Branchiostoma floridae estExt_fgenesh2_pg.C_20279 I 0.974
smad1 Oryzias latipes ENSORLG00000007377 I 0.974
ENSMEUG00000006332 Macropus eugenii ENSMEUG00000006332 I 0.968
smad5 Oryzias latipes ENSORLG00000009395 I 0.966
smad9 Danio rerio ENSDARG00000021938 I 0.966
ENSAMXG00000016040 Astyanax mexicanus ENSAMXG00000016040 I 0.966
smad5 Tetraodon nigroviridis ENSTNIG00000003701 I 0.966
smad5 Takifugu rubripes ENSTRUG00000001329 I 0.966
Smad5 Dipodomys ordii ENSDORG00000004533 I 0.966
Gfo_R005758 Geospiza fortis Gfo_R005758 I 0.964
SMAD9 Monodelphis domestica ENSMODG00000010017 I 0.964
SMAD9 Gallus gallus ENSGALG00000017050 I 0.964
ENSPFOG00000015910 Poecilia formosa ENSPFOG00000015910 I 0.964
smad9 Oryzias latipes ENSORLG00000003956 I 0.964
SMAD9 Meleagris gallopavo ENSMGAG00000015060 I 0.964
SMAD9 Anolis carolinensis ENSACAG00000004463 I 0.964
Alligator_sinensis_CCG012577.1 Alligator sinensis Alligator_sinensis_CCG012577.1 I 0.964
ENSAPLG00000009135 Anas platyrhynchos ENSAPLG00000009135 I 0.964
ENSMEUG00000007556 Macropus eugenii ENSMEUG00000007556 I 0.964
ENSSHAG00000001186 Sarcophilus harrisii ENSSHAG00000001186 I 0.964
ENSFALG00000008280 Ficedula albicollis ENSFALG00000008280 I 0.964
ENSPFOG00000015984 Poecilia formosa ENSPFOG00000015984 I 0.964
ENSPSIG00000002483 Pelodiscus sinensis ENSPSIG00000002483 I 0.964
Aan_R005227 Calypte anna Aan_R005227 I 0.964
Brh_R009512 Buceros rhinoceros Brh_R009512 I 0.964
Pvit_04328 Pogona vitticeps Pvit_04328 I 0.964
ENSXMAG00000008595 Xiphophorus maculatus ENSXMAG00000008595 I 0.964
Afo_R003117 Aptenodytes forsteri Afo_R003117 I 0.964
Tal_R004657 Tyto alba Tal_R004657 I 0.964
ENSPANG00000005514 Papio anubis ENSPANG00000005514 I 0.961
SMAD5 Microcebus murinus ENSMICG00000007315 I 0.961
ENSPMAG00000009833 Petromyzon marinus ENSPMAG00000009833 I 0.961
SMAD5 Myotis lucifugus ENSMLUG00000002321 I 0.961
SMAD5 Macaca mulatta ENSMMUG00000000340 I 0.961
SMAD5 Monodelphis domestica ENSMODG00000015152 I 0.961
Cmyd_10013071 Chelonia mydas Cmyd_10013071 I 0.961
ENSOARG00000014930 Ovis aries ENSOARG00000014930 I 0.961
Aan_R008601 Calypte anna Aan_R008601 I 0.961
ENSBTAP00000029021-D1 Bos grunniens ENSBTAP00000029021-D1 I 0.961
ENSNLEG00000008403 Nomascus leucogenys ENSNLEG00000008403 I 0.961
Smad5 Mus musculus ENSMUSG00000021540 D 0.961
SMAD5 Oryctolagus cuniculus ENSOCUG00000004937 I 0.961
Brh_R001419 Buceros rhinoceros Brh_R001419 I 0.961
Alligator_sinensis_CCG001358.1 Alligator sinensis Alligator_sinensis_CCG001358.1 I 0.961
SMAD5 Otolemur garnettii ENSOGAG00000009601 I 0.961
SMAD5 Procavia capensis ENSPCAG00000006817 I 0.961
ENSMPUG00000009935 Mustela putorius furo ENSMPUG00000009935 I 0.961
Afo_R012117 Aptenodytes forsteri Afo_R012117 I 0.961
Myotis_brandtii_SMAD5_10032631 Myotis brandtii Myotis_brandtii_SMAD5_10032631 I 0.961
SMAD5 Cavia porcellus ENSCPOG00000005773 I 0.961
ENSSHAG00000006806 Sarcophilus harrisii ENSSHAG00000006806 I 0.961
SMAD5 Canis familiaris ENSCAFG00000001094 I 0.961
SMAD5 Bos taurus ENSBTAG00000021772 I 0.961
ENSCSAG00000013343 Chlorocebus sabaeus ENSCSAG00000013343 I 0.961
Tal_R002325 Tyto alba Tal_R002325 I 0.961
SMAD5 Vicugna pacos ENSVPAG00000007328 I 0.961
SMAD5 Dasypus novemcinctus ENSDNOG00000006004 I 0.961
SMAD5 Sorex araneus ENSSARG00000009234 I 0.961
SMAD5 Sus scrofa ENSSSCG00000014319 I 0.961
ENSSSCG00000025920 Sus scrofa ENSSSCG00000025920 I 0.961
SMAD5 Taeniopygia guttata ENSTGUG00000001214 I 0.961
CGI_10014747 Crassostrea gigas CGI_10014747 I 0.961
ENSTSYG00000005318 Tarsius syrichta ENSTSYG00000005318 I 0.961
SMAD5 Tursiops truncatus ENSTTRG00000016274 I 0.961
DAPPUDRAFT_300607 Daphnia pulex DAPPUDRAFT_300607 I 0.961
SMAD5 Anolis carolinensis ENSACAG00000000815 I 0.961
ENSSTOG00000011799 Ictidomys tridecemlineatus ENSSTOG00000011799 I 0.961
SMAD5 Tupaia belangeri ENSTBEG00000002769 I 0.961
ENSAMEG00000017941 Ailuropoda melanoleuca ENSAMEG00000017941 I 0.961
Smad5 Rattus norvegicus ENSRNOG00000022870 D 0.961
Pvit_01886 Pogona vitticeps Pvit_01886 I 0.961
SMAD5 Equus caballus ENSECAG00000018506 I 0.961
Gfo_R013176 Geospiza fortis Gfo_R013176 I 0.961
SMAD5 Gallus gallus ENSGALG00000006309 I 0.961
SMAD5 Gorilla gorilla ENSGGOG00000023966 I 0.961
SMAD5 Loxodonta africana ENSLAFG00000004338 I 0.961
ENSPSIG00000003731 Pelodiscus sinensis ENSPSIG00000003731 I 0.961
ENSP00000384803 Macaca fascicularis ENSP00000384803 I 0.961
ENSGMOG00000005788 Gadus morhua ENSGMOG00000005788 I 0.961
ENSPPYG00000015808 Pongo abelii ENSPPYG00000015808 I 0.961
ENSMEUG00000005813 Macropus eugenii ENSMEUG00000005813 I 0.961
SMAD5 Echinops telfairi ENSETEG00000019912 I 0.961
SMAD5 Erinaceus europaeus ENSEEUG00000001684 I 0.961
SMAD5 Meleagris gallopavo ENSMGAG00000008031 I 0.961
SMAR012602 Strigamia maritima SMAR012602 I 0.961
ENSFALG00000008067 Ficedula albicollis ENSFALG00000008067 I 0.961
SMAD5 Felis catus ENSFCAG00000025329 I 0.961
SMAD5 Pteropus vampyrus ENSPVAG00000016214 I 0.961
ENSPPYG00000005285 Pongo abelii ENSPPYG00000005285 I 0.961
SMAD9 Tursiops truncatus ENSTTRG00000007903 I 0.952
SMAD9 Pan troglodytes ENSPTRG00000005788 I 0.952
SMAD9 Sorex araneus ENSSARG00000011878 I 0.952
Smad9 Rattus norvegicus ENSRNOG00000000091 D 0.952
LOC103691556 Rattus norvegicus ENSRNOG00000058416 I 0.952
SMAD9 Pteropus vampyrus ENSPVAG00000013871 I 0.952
SMAD9 Sus scrofa ENSSSCG00000009357 I 0.952
SMAD9 Procavia capensis ENSPCAG00000002604 I 0.952
ENSSTOG00000007103 Ictidomys tridecemlineatus ENSSTOG00000007103 I 0.952
SMAD9 Tupaia belangeri ENSTBEG00000011491 I 0.952
SMAD9 Microcebus murinus ENSMICG00000003343 I 0.952
SMAD9 Homo sapiens ENSG00000120693 D 0.952
SMAD9 Felis catus ENSFCAG00000003813 I 0.952
SMAD9 Echinops telfairi ENSETEG00000020236 I 0.952
Myotis_brandtii_SMAD9_10010468 Myotis brandtii Myotis_brandtii_SMAD9_10010468 I 0.952
ENSAMEG00000014442 Ailuropoda melanoleuca ENSAMEG00000014442 I 0.952
AAK02019 Xenopus laevis AAK02019 I 0.952
SMAD9 Gorilla gorilla ENSGGOG00000001017 I 0.952
AAL86774 Xenopus laevis AAL86774 I 0.952
SMAD9 Equus caballus ENSECAG00000012534 I 0.952
ENSPANG00000014460 Papio anubis ENSPANG00000014460 I 0.952
SMAD9 Canis familiaris ENSCAFG00000006162 I 0.952
SMAD9 Bos taurus ENSBTAG00000007589 I 0.952
ENSCSAG00000017872 Chlorocebus sabaeus ENSCSAG00000017872 I 0.952
Smad9 Dipodomys ordii ENSDORG00000002526 I 0.952
AAL86773 Xenopus laevis AAL86773 I 0.952
smad9 Xenopus tropicalis XB-GENE-484686 I 0.952
ENSP00000382216 Macaca fascicularis ENSP00000382216 I 0.952
ENSNLEG00000001639 Nomascus leucogenys ENSNLEG00000001639 I 0.952
Smad9 Mus musculus ENSMUSG00000027796 D 0.952
SMAD9 Ornithorhynchus anatinus ENSOANG00000015497 I 0.952
SMAD9 Oryctolagus cuniculus ENSOCUG00000007453 I 0.952
SMAD9 Ochotona princeps ENSOPRG00000004923 I 0.952
SMAD9 Otolemur garnettii ENSOGAG00000002742 I 0.952
SMAD9 Macaca mulatta ENSMMUG00000009914 I 0.952
ENSMPUG00000001838 Mustela putorius furo ENSMPUG00000001838 I 0.952
SMAD9 Myotis lucifugus ENSMLUG00000006399 I 0.952
ENSBTAP00000029021-D3 Bos grunniens ENSBTAP00000029021-D3 I 0.952
ENSLOCG00000008478 Lepisosteus oculatus ENSLOCG00000008478 I 0.952
SMAD9 Loxodonta africana ENSLAFG00000002903 I 0.952
ENSAMXG00000010992 Astyanax mexicanus ENSAMXG00000010992 I 0.951
smad5 Danio rerio ENSDARG00000037238 I 0.951
ENSLOCG00000011514 Lepisosteus oculatus ENSLOCG00000011514 I 0.951
Ogr17529 Ophisaurus gracilis Ogr17529 I 0.951
ENSONIG00000015791 Oreochromis niloticus ENSONIG00000015791 I 0.951
HHAL000023-PA Halyomorpha halys HHAL000023-PA I 0.948
ENSTSYG00000005021 Tarsius syrichta ENSTSYG00000005021 I 0.941
SMAD9 Cavia porcellus ENSCPOG00000010255 I 0.941
ENSLACG00000011178 Latimeria chalumnae ENSLACG00000011178 I 0.941
ACYPI010124 Acyrthosiphon pisum ACYPI010124 I 0.939
Mad Drosophila melanogaster FBgn0011648 D 0.935
ACUA017601 Anopheles culicifacies ACUA017601 I 0.935
GF20577 Drosophila ananassae FBgn0097583 I 0.935
GG24457 Drosophila erecta FBgn0116589 I 0.935
ACUA022001 Anopheles culicifacies ACUA022001 I 0.935
AALB000402 Anopheles albimanus AALB000402 I 0.935
AFUN010580 Anopheles funestus AFUN010580 I 0.935
LLOJ009024 Lutzomyia longipalpis LLOJ009024 I 0.935
PPAI007902 Phlebotomus papatasi PPAI007902 I 0.935
AMIN001006 Anopheles minimus AMIN001006 I 0.935
ADAC002355 Anopheles darlingi ADAC002355 I 0.935
GD22774 Drosophila simulans FBgn0194168 I 0.935
AEPI001857 Anopheles epiroticus AEPI001857 I 0.935
GH10284 Drosophila grimshawi FBgn0117765 I 0.935
GM18164 Drosophila sechellia FBgn0173071 I 0.935
GA28973 Drosophila pseudoobscura FBgn0250331 I 0.935
GE14935 Drosophila yakuba FBgn0232525 I 0.935
GK18268 Drosophila willistoni FBgn0220267 I 0.935
GJ19553 Drosophila virilis FBgn0206695 I 0.935
GI17981 Drosophila mojavensis FBgn0140721 I 0.935
GL26531 Drosophila persimilis FBgn0164113 I 0.935
ENSAPLG00000003593 Anas platyrhynchos ENSAPLG00000003593 I 0.935
RPRC008357 Rhodnius prolixus RPRC008357 I 0.935
AAL86772 Xenopus laevis AAL86772 I 0.931
smad9.S Xenopus laevis XB-GENE-865114 I 0.931
ENSLACG00000007324 Latimeria chalumnae ENSLACG00000007324 I 0.931
smad9 Gasterosteus aculeatus ENSGACG00000020562 I 0.931
MDOA015236 Musca domestica MDOA015236 I 0.922
MDOA012257 Musca domestica MDOA012257 I 0.922
ISCW010869 Ixodes scapularis ISCW010869 I 0.922
smad9 Takifugu rubripes ENSTRUG00000001196 I 0.922
ENSAMXG00000016178 Astyanax mexicanus ENSAMXG00000016178 I 0.922
BGIBMGA010481 Bombyx mori BGIBMGA010481 I 0.922
ENSONIG00000012614 Oreochromis niloticus ENSONIG00000012614 I 0.922
ENSGMOG00000012301 Gadus morhua ENSGMOG00000012301 I 0.922
smad9 Tetraodon nigroviridis ENSTNIG00000009925 I 0.922
ENSOARG00000010293 Ovis aries ENSOARG00000010293 I 0.922
SMAD9 Taeniopygia guttata ENSTGUG00000011897 I 0.921
HHAL005200-PA Halyomorpha halys HHAL005200-PA I 0.916
ENSCING00000022875 Ciona intestinalis ENSCING00000022875 I 0.916
CLEC006591 Cimex lectularius CLEC006591 I 0.916
SMAD9 Dasypus novemcinctus ENSDNOG00000048385 I 0.912
Ocbimv22002448m.g Octopus bimaculoides Ocbimv22002448m.g I 0.912
ENSGMOG00000007465 Gadus morhua ENSGMOG00000007465 I 0.912
ENSSHAG00000002348 Sarcophilus harrisii ENSSHAG00000002348 I 0.912
MCOS_0000603801 Mesocestoides corti MCOS_0000603801 I 0.909
EmuJ_001018300 Echinococcus multilocularis EmuJ_001018300 I 0.909
TASK_0000610701 Taenia asiatica TASK_0000610701 I 0.909
TTAC_0000954401 Hydatigera taeniaeformis TTAC_0000954401 I 0.909
ECANG7_02712 Echinococcus canadensis ECANG7_02712 I 0.909
L798_03803 Zootermopsis nevadensis L798_03803 I 0.909
DILT_0000355601 Diphyllobothrium latum DILT_0000355601 I 0.909
TC014921 Tribolium castaneum TC014921 I 0.904
ENSCSAVG00000002875 Ciona savignyi ENSCSAVG00000002875 I 0.904
TC014924 Tribolium castaneum TC014924 I 0.902
CPIJ000420 Culex quinquefasciatus CPIJ000420 I 0.896
Sjc_0006780 Schistosoma japonicum Sjc_0006780 I 0.896
HmN_000160100 Hymenolepis microstoma HmN_000160100 I 0.896
HDID_0000986701 Hymenolepis diminuta HDID_0000986701 I 0.896
SCUD_0000553301 Schistosoma curassoni SCUD_0000553301 I 0.896
SROB_0000039301 Schistosoma rodhaini SROB_0000039301 I 0.896
CpipJ_CPIJ000420 Culex pipiens CpipJ_CPIJ000420 I 0.896
TsM_000781600 Taenia solium TsM_000781600 I 0.896
SMTD_0001194901 Schistosoma mattheei SMTD_0001194901 I 0.896
SMRZ_0000889701 Schistosoma margrebowiei SMRZ_0000889701 I 0.896
Smp_013060 Schistosoma mansoni Smp_013060 I 0.896
HNAJ_0000781101 Hymenolepis nana HNAJ_0000781101 I 0.896
TriadG50301 Trichoplax adhaerens TriadG50301 I 0.892
ACHR005633 Anopheles christyi ACHR005633 I 0.892
ADIR010877 Anopheles dirus ADIR010877 I 0.892
AAEL005513 Aedes aegypti AAEL005513 I 0.892
AMEC005585 Anopheles melas AMEC005585 I 0.892
ASTEI05192 Anopheles stephensi ASTEI05192 I 0.892
AQUA000239 Anopheles quadriannulatus AQUA000239 I 0.892
Cflo_02382--XP_392819.2_APIME Camponotus floridanus Cflo_02382--XP_392819.2_APIME I 0.892
AMAM023956 Anopheles maculatus AMAM023956 I 0.892
AGAP008551 Anopheles gambiae AGAP008551 I 0.892
ACEP16085 Atta cephalotes ACEP16085 I 0.892
AFAF000844 Anopheles farauti AFAF000844 I 0.892
AARA011030 Anopheles arabiensis AARA011030 I 0.892
GB44177 Apis mellifera GB44177 I 0.892
NV13248 Nasonia vitripennis NV13248 I 0.892
LCUP000453 Lucilia cuprina LCUP000453 I 0.892
LotgiG104873 Lottia gigantea LotgiG104873 I 0.892
KGM_04785 Danaus plexippus KGM_04785 I 0.892
HMEL009295 Heliconius melpomene HMEL009295 I 0.892
AMEM010864 Anopheles merus AMEM010864 I 0.892
Hsal_07345--XP_392819.2_APIME Harpegnathos saltator Hsal_07345--XP_392819.2_APIME I 0.892
AATE020501 Anopheles atroparvus AATE020501 I 0.892
SINV11024 Solenopsis invicta SINV11024 I 0.892
HelroG186716 Helobdella robusta HelroG186716 I 0.883
csin106589 Clonorchis sinensis csin106589 I 0.883
T265_01150 Opisthorchis viverrini T265_01150 I 0.883
PHUM612490 Pediculus humanus PHUM612490 I 0.882
LDEC003904 Leptinotarsa decemlineata LDEC003904 I 0.880
SPU_023107 Strongylocentrotus purpuratus SPU_023107 I 0.873
SPU_020722 Strongylocentrotus purpuratus SPU_020722 I 0.873
tetur04g09040 Tetranychus urticae tetur04g09040 I 0.870
D915_05666 Fasciola hepatica D915_05666 I 0.867
XP_002160208.1 Hydra magnipapillata XP_002160208.1 I 0.867
ECPE_0001803101 Echinostoma caproni ECPE_0001803101 I 0.867
Sakowv30001252m.g Saccoglossus kowalevskii Sakowv30001252m.g I 0.863
SMAD1 Vicugna pacos ENSVPAG00000003340 I 0.863
PXEA_0003021401 Protopolystoma xenopodis PXEA_0003021401 I 0.863
YQE_07842 Dendroctonus ponderosae YQE_07842 I 0.862
BGLB010651 Biomphalaria glabrata BGLB010651 I 0.862
NEMVEDRAFT_v1g228395 Nematostella vectensis NEMVEDRAFT_v1g228395 I 0.857
SMU15039699 Schmidtea mediterranea SMU15039699 I 0.857
ACYPI007984 Acyrthosiphon pisum ACYPI007984 I 0.855
NV15769 Nasonia vitripennis NV15769 I 0.853
PHUM612590 Pediculus humanus PHUM612590 I 0.853
ENSSHAG00000000426 Sarcophilus harrisii ENSSHAG00000000426 I 0.853
TCNE_0001440901 Toxocara canis TCNE_0001440901 I 0.844
TTRE_0000645601 Trichuris trichiura TTRE_0000645601 I 0.844
D918_06928 Trichuris suis D918_06928 I 0.844
BGLB001215 Biomphalaria glabrata BGLB001215 I 0.843
SMAD5 Choloepus hoffmanni ENSCHOG00000001168 I 0.842
TMUE_s0173000400 Trichuris muris TMUE_s0173000400 I 0.833
SNAPOd2T00013556001 Oikopleura dioica SNAPOd2T00013556001 I 0.831
ENSSTOG00000010836 Ictidomys tridecemlineatus ENSSTOG00000010836 I 0.824
GPUH_0002623401 Gongylonema pulchrum GPUH_0002623401 I 0.818
GPUH_0002149301 Gongylonema pulchrum GPUH_0002149301 I 0.818
ASU_08570 Ascaris suum ASU_08570 I 0.807
DME_0000409101 Dracunculus medinensis DME_0000409101 I 0.807
nLs.2.1.2.g04119 Litomosoides sigmodontis nLs.2.1.2.g04119 I 0.805
nRc.2.0.1.g02634 Romanomermis culicivorax nRc.2.0.1.g02634 I 0.805
nDi.2.2.2.g04365 Dirofilaria immitis nDi.2.2.2.g04365 I 0.805
L596_g25216 Steinernema carpocapsae L596_g25216 I 0.805
nAv.1.0.1.g00979 Acanthocheilonema viteae nAv.1.0.1.g00979 I 0.805
Bm5383 Brugia malayi Bm5383 I 0.805
WUBG_01190 Wuchereria bancrofti WUBG_01190 I 0.805
WBGene00246233 Onchocerca volvulus WBGene00246233 I 0.805
SMU15035000 Schmidtea mediterranea SMU15035000 I 0.795
ENSSHAG00000001378 Sarcophilus harrisii ENSSHAG00000001378 I 0.784
ML01205a Mnemiopsis leidyi ML01205a I 0.784
L889_g17000 Steinernema feltiae L889_g17000 I 0.783
ENSAPLG00000004964 Anas platyrhynchos ENSAPLG00000004964 I 0.781
SMAD3 Homo sapiens ENSG00000166949 D 0.781
ENSMGAG00000001351 Meleagris gallopavo ENSMGAG00000001351 I 0.781
SMUV_0000762601 Syphacia muris SMUV_0000762601 I 0.779
NEMVEDRAFT_v1g168041 Nematostella vectensis NEMVEDRAFT_v1g168041 I 0.779
MESCA008319 Megaselia scalaris MESCA008319 I 0.779
Brh_R001115 Buceros rhinoceros Brh_R001115 I 0.778
ENSPMAG00000004234 Petromyzon marinus ENSPMAG00000004234 I 0.778
ENSAPLG00000007006 Anas platyrhynchos ENSAPLG00000007006 I 0.778
ENSPSIG00000010579 Pelodiscus sinensis ENSPSIG00000010579 I 0.778
Tal_R001210 Tyto alba Tal_R001210 I 0.778
EmuJ_000893400 Echinococcus multilocularis EmuJ_000893400 I 0.775
DILT_0001805701 Diphyllobothrium latum DILT_0001805701 I 0.775
TASK_0000487901 Taenia asiatica TASK_0000487901 I 0.775
TsM_000653100 Taenia solium TsM_000653100 I 0.775
ECANG7_00782 Echinococcus canadensis ECANG7_00782 I 0.775
TTAC_0000691201 Hydatigera taeniaeformis TTAC_0000691201 I 0.775
ALUE_0002104001 Ascaris lumbricoides ALUE_0002104001 I 0.771
ASIM_0002076001 Anisakis simplex ASIM_0002076001 I 0.771
SPAL_0000266700 Strongyloides papillosus SPAL_0000266700 I 0.771
PTRK_0001409600 Parastrongyloides trichosuri PTRK_0001409600 I 0.771
nOo.2.0.1.g11302 Onchocerca ochengi nOo.2.0.1.g11302 I 0.766
Aqu1.229822 Amphimedon queenslandica Aqu1.229822 I 0.766
CpipJ_CPIJ004623 Culex pipiens CpipJ_CPIJ004623 I 0.765
Aqu1.228116 Amphimedon queenslandica Aqu1.228116 I 0.765
HDID_0000526701 Hymenolepis diminuta HDID_0000526701 I 0.765
HNAJ_0000459401 Hymenolepis nana HNAJ_0000459401 I 0.765
HmN_000026900 Hymenolepis microstoma HmN_000026900 I 0.765
CPIJ004623 Culex quinquefasciatus CPIJ004623 I 0.765
maker-nMf.1.1.scaf04862-augustus-gene-0.4 Meloidogyne floridensis maker-nMf.1.1.scaf04862-augustus-gene-0.4 I 0.759
SVE_1899900 Strongyloides venezuelensis SVE_1899900 I 0.759
MESCA005689 Megaselia scalaris MESCA005689 I 0.755
Minc07882 Meloidogyne incognita Minc07882 I 0.753
EVEC_0000230001 Enterobius vermicularis EVEC_0000230001 I 0.753
scaffold778-EXSNAP2012.5 Pristionchus exspectatus scaffold778-EXSNAP2012.5 N 0.753
SSTP_0000598700 Strongyloides stercoralis SSTP_0000598700 I 0.745
TCLT_0000734101 Thelazia callipaeda TCLT_0000734101 I 0.745
PXEA_0002306401 Protopolystoma xenopodis PXEA_0002306401 I 0.744
DICVIV_05604 Dictyocaulus viviparus DICVIV_05604 N 0.740
BXY_1645200 Bursaphelenchus xylophilus BXY_1645200 I 0.735
ML093050a Mnemiopsis leidyi ML093050a I 0.735
L898_g8161 Steinernema monticolum L898_g8161 I 0.735
ML011743a Mnemiopsis leidyi ML011743a I 0.730
CapteG167863 Capitella teleta CapteG167863 I 0.727
AAB39329 Xenopus laevis AAB39329 I 0.727
ENSGALG00000014184 Gallus gallus ENSGALG00000014184 I 0.727
smad3b Takifugu rubripes ENSTRUG00000014802 I 0.727
Aan_R002236 Calypte anna Aan_R002236 I 0.727
MCINX009972 Melitaea cinxia MCINX009972 I 0.724
HMEL009327 Heliconius melpomene HMEL009327 N 0.724
smad3b Tetraodon nigroviridis ENSTNIG00000008432 I 0.723
ENSGMOG00000008364 Gadus morhua ENSGMOG00000008364 I 0.723
Smad3 Mus musculus ENSMUSG00000032402 D 0.718
csin108472 Clonorchis sinensis csin108472 I 0.716
T265_03875 Opisthorchis viverrini T265_03875 I 0.716
BGLB011859 Biomphalaria glabrata BGLB011859 I 0.716
SMAD1 Ochotona princeps ENSOPRG00000012775 I 0.716
ISCW001846 Ixodes scapularis ISCW001846 I 0.714
ENSAMXG00000002880 Astyanax mexicanus ENSAMXG00000002880 I 0.714
L798_14024 Zootermopsis nevadensis L798_14024 I 0.714
smad2.S Xenopus laevis XB-GENE-864923 I 0.714
SMAR008230 Strigamia maritima SMAR008230 I 0.714
smad3a Takifugu rubripes ENSTRUG00000016858 I 0.714
ENSPFOG00000006336 Poecilia formosa ENSPFOG00000006336 I 0.714
smad3b Gasterosteus aculeatus ENSGACG00000005092 I 0.714
smad3a Danio rerio ENSDARG00000036096 I 0.714
smad3a Tetraodon nigroviridis ENSTNIG00000009546 I 0.714
Gfo_R012055 Geospiza fortis Gfo_R012055 I 0.713
SMAD2 Sorex araneus ENSSARG00000003487 I 0.713
ENSBTAP00000003668-D4 Bos grunniens ENSBTAP00000003668-D4 I 0.713
estExt_gwp.C_540260 Branchiostoma floridae estExt_gwp.C_540260 I 0.713
ENSSTOG00000003788 Ictidomys tridecemlineatus ENSSTOG00000003788 I 0.713
estExt_fgenesh2_pg.C_1720042 Branchiostoma floridae estExt_fgenesh2_pg.C_1720042 I 0.713
smad3b Danio rerio ENSDARG00000010207 I 0.713
ENSXMAG00000002377 Xiphophorus maculatus ENSXMAG00000002377 I 0.711
TELCIR_10810 Teladorsagia circumcincta TELCIR_10810 N 0.711
SVUK_0001208601 Strongylus vulgaris SVUK_0001208601 N 0.711
NECAME_03891 Necator americanus NECAME_03891 N 0.711
HPLM_0000851001 Haemonchus placei HPLM_0000851001 N 0.711
HCOI01110700 Haemonchus contortus HCOI01110700 N 0.711
ENSLOCG00000013897 Lepisosteus oculatus ENSLOCG00000013897 I 0.711
ANCCAN_05759 Ancylostoma caninum ANCCAN_05759 N 0.711
ACAC_0000906701 Angiostrongylus cantonensis ACAC_0000906701 N 0.711
smad3a Oryzias latipes ENSORLG00000002207 I 0.703
Smad3 Rattus norvegicus ENSRNOG00000008620 I 0.703
SMAD3 Pan troglodytes ENSPTRG00000007199 I 0.703
ENSP00000332973-D1 Bos grunniens ENSP00000332973-D1 I 0.703
SMAD3 Ochotona princeps ENSOPRG00000014996 I 0.703
SMAD3 Callithrix jacchus ENSCJAG00000002088 I 0.703
ENSNLEG00000012983 Nomascus leucogenys ENSNLEG00000012983 I 0.703
SMAD3 Otolemur garnettii ENSOGAG00000014217 I 0.703
SMAD3 Canis familiaris ENSCAFG00000017388 I 0.703
ENSSTOG00000010286 Ictidomys tridecemlineatus ENSSTOG00000010286 I 0.703
SMAD3 Microcebus murinus ENSMICG00000006119 I 0.703
SMAD3 Dasypus novemcinctus ENSDNOG00000044090 I 0.703
ENSPPYG00000006583 Pongo abelii ENSPPYG00000006583 I 0.703
SPU_017642 Strongylocentrotus purpuratus SPU_017642 I 0.703
ENSAMEG00000003318 Ailuropoda melanoleuca ENSAMEG00000003318 I 0.703
smad3.L Xenopus laevis XB-GENE-864816 I 0.703
ENSGACG00000017820 Gasterosteus aculeatus ENSGACG00000017820 I 0.703
SMAD3 Echinops telfairi ENSETEG00000003356 I 0.703
SMAD3 Pteropus vampyrus ENSPVAG00000002626 I 0.703
Myotis_brandtii_Smad3_10022298 Myotis brandtii Myotis_brandtii_Smad3_10022298 I 0.703
SMAD3 Macaca mulatta ENSMMUG00000015455 I 0.701
ENSGALG00000007870 Gallus gallus ENSGALG00000007870 I 0.701
SMAD3 Monodelphis domestica ENSMODG00000009609 I 0.701
ENSONIG00000015464 Oreochromis niloticus ENSONIG00000015464 I 0.701
Gfo_R005908 Geospiza fortis Gfo_R005908 I 0.701
ENSFALG00000012861 Ficedula albicollis ENSFALG00000012861 I 0.701
ENSPANG00000016627 Papio anubis ENSPANG00000016627 I 0.701
ENSCSAG00000013275 Chlorocebus sabaeus ENSCSAG00000013275 I 0.701
Afo_R015053 Aptenodytes forsteri Afo_R015053 I 0.701
Aan_R005610 Calypte anna Aan_R005610 I 0.701
BXY_1512700 Bursaphelenchus xylophilus BXY_1512700 N 0.701
NBR_0000522801 Nippostrongylus brasiliensis NBR_0000522801 I 0.700