Smad5 (Mus musculus)
SMAD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF03165 (MH1) IPR003619 ENSMUSG00000021540 T324767_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in SMAD protein signal transduction; cellular response to BMP stimulus; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; osteoblast fate commitment; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; egg cylinder; embryo mesenchyme; and genitourinary system. Orthologous to human SMAD5 (SMAD family member 5). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Smad5
M11288_2.00		 Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD5_01		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Smad5
M11292_2.00 		Rattus norvegicus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD5_03 		1.000 1.000
SMAD1
M11286_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD1_01 		0.961 0.961
SMAD1
M11287_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD1_Q6 		0.961 0.961
SMAD9
M11274_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD8_01 		0.931 0.931
Smad9
M11290_2.00 		Rattus norvegicus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD8_02 		0.931 0.931
Smad9
M11289_2.00 		Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD8_03 		0.931 0.931
Mad
M06446_2.00 		Drosophila melanogaster
GYGHCGBCVS
SBGVCGDCRC		 B1H
Zhu et al.(2011)
Mad_FlyReg_FBgn0011648 		0.892 0.892
Mad
M08427_2.00 		Drosophila melanogaster
SNGRCGMSRVSRBNS
SNVYSBYSKCGYCNS		 ChIP-chip
Mathelier et al.(2014)
MA0535.1 		0.892 0.892
Mad
M09692_2.00 		Drosophila melanogaster
KCBGSHGKCGCSNC
GNSGCGMCDSCVGM		 Misc
Kulakovskiy et al.(2009)
Mad 		0.892 0.892
Mad
M11293_2.00 		Drosophila melanogaster Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
I$MAD_Q6 		0.892 0.892
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000065798 SMAD 31 132
ENSMUSP00000105500 SMAD 31 132
ENSMUSP00000105502 SMAD 31 132

Links

Other SMAD family TFs
Other Mus musculus TFs

Invalid Input OrderBy

409 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action