Smad3 (Mus musculus)
SMAD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF03165 (MH1) IPR003619 ENSMUSG00000032402 T324772_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in several processes, including JNK cascade; negative regulation of osteoblast proliferation; and positive regulation of chondrocyte differentiation. Acts upstream of or within several processes, including animal organ development; regulation of transcription by RNA polymerase II; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; limb; and nervous system. Used to study osteoarthritis. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic cancer. Orthologous to human SMAD3 (SMAD family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Smad3
M00192_2.00		 Mus musculus
NNNNNMGMCN
NGKCKNNNNN		 PBM
Badis et al.(2009)
Smad3_3805		 (Direct) (Direct)
Smad3
M09384_2.00		 Mus musculus
NBCTSHCWSCWB
VWGSWGDSAGVN		 Misc
Kulakovskiy et al.(2013)
SMAD3_MOUSE.H11MO.0.B		 (Direct) (Direct)
Smad3
M09637_2.00		 Mus musculus
BYAGMCWN
NWGKCTRV		 Misc
Heinz et al.(2010)
NPC-Smad3_GSE36673		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
SMAD3
M03482_2.00 		Homo sapiens
YGTCTAGACA
TGTCTAGACR		 SELEX
Jolma et al.(2013)
SMAD3_1 		1.000 1.000
SMAD3
M09380_2.00 		Homo sapiens
NBCTSHCWSCWB
VWGSWGDSAGVN		 Misc
Kulakovskiy et al.(2013)
SMAD3_HUMAN.H11MO.0.B 		0.901 0.901
SMAD3
M11283_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD3_Q6_01 		0.939 0.939
SMAD3
M11284_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD3_Q6_02 		0.939 0.939
SMAD3
M11285_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD3_Q6 		0.939 0.939
SMAD9
M11274_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD8_01 		0.723 0.723
SMAD1
M11286_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD1_01 		0.742 0.742
Smad9
M11290_2.00 		Rattus norvegicus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD8_02 		0.723 0.723
SMAD1
M11287_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD1_Q6 		0.742 0.742
Smad9
M11289_2.00 		Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD8_03 		0.723 0.723
Mad
M06446_2.00 		Drosophila melanogaster
GYGHCGBCVS
SBGVCGDCRC		 B1H
Zhu et al.(2011)
Mad_FlyReg_FBgn0011648 		0.703 0.703
Mad
M08427_2.00 		Drosophila melanogaster
SNGRCGMSRVSRBNS
SNVYSBYSKCGYCNS		 ChIP-chip
Mathelier et al.(2014)
MA0535.1 		0.703 0.703
Mad
M09692_2.00 		Drosophila melanogaster
KCBGSHGKCGCSNC
GNSGCGMCDSCVGM		 Misc
Kulakovskiy et al.(2009)
Mad 		0.703 0.703
Mad
M11293_2.00 		Drosophila melanogaster Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
I$MAD_Q6 		0.703 0.703
Smad5
M11288_2.00 		Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD5_01 		0.703 0.703
Smad5
M11292_2.00 		Rattus norvegicus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SMAD5_03 		0.704 0.704
For this family, TFs with SR scores > 0.700 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00192_2.00 SMAD 21 121

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000034973 SMAD 31 131
ENSMUSP00000116790 SMAD 1 66
ENSMUSP00000122217 SMAD 2 72

Links

Other SMAD family TFs
Other Mus musculus TFs

Invalid Input OrderBy

375 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action