CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Smad4
(
Rattus norvegicus
)
SMAD
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF03165 (MH1)
IPR003619
ENSRNOG00000051965
T324934_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables DNA binding activity; SMAD binding activity; and filamin binding activity. Involved in several processes, including ERK1 and ERK2 cascade; cellular response to glucose stimulus; and positive regulation of cardiac muscle cell apoptotic process. Located in cytoplasm and nucleus. Part of protein-containing complex. Used to study pulmonary fibrosis. Biomarker of several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); prostatitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including female reproductive organ cancer (multiple); hereditary hemorrhagic telangiectasia; juvenile polyposis syndrome; juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome; and seminoma. Orthologous to human SMAD4 (SMAD family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Smad4
M05889_2.00
Mus musculus
KCYAGACR
YGTCTRGM
SMiLE-seq
Isakova et al.(2017)
Smad4
1.000
1.000
SMAD4
M09377_2.00
Homo sapiens
DRGTGNSAGACWN
NWGTCTSNCACYH
Misc
Kulakovskiy et al.(2013)
SMAD4_HUMAN.H11MO.0.B
1.000
1.000
Smad4
M09382_2.00
Mus musculus
DGWGNBAGVCWN
NWGBCTVNCWCH
Misc
Kulakovskiy et al.(2013)
SMAD4_MOUSE.H11MO.0.A
1.000
1.000
SMAD4
M09634_2.00
Homo sapiens
NNNYGTCTGS
SCAGACRNNN
Misc
Heinz et al.(2010)
ESC-SMAD4_GSE29422
1.000
1.000
SMAD4
M11275_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD4_Q4
1.000
1.000
SMAD4
M11276_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD4_Q6_01
1.000
1.000
SMAD4
M11277_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD4_Q6
1.000
1.000
Med
M06447_2.00
Drosophila melanogaster
KCGBCDKKSHVT
ABDSMMHGVCGM
B1H
Zhu et al.(2011)
Med_FlyReg_FBgn0011655
0.961
0.961
Med
M09693_2.00
Drosophila melanogaster
YYBYVYCTGYY
RRCAGRBRVRR
Misc
Kulakovskiy et al.(2009)
Med
0.961
0.961
For this family, TFs with SR scores >
0.700
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSRNOP00000070425
SMAD
36
137
AKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVV
ENSRNOP00000074882
SMAD
36
137
AKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVV
Links
Other
SMAD
family TFs
Other
Rattus norvegicus
TFs
218 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy