sma-4 (Caenorhabditis elegans)
SMAD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF03165 (MH1) IPR003619 WBGene00004858 T325233_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and positive regulation of cell size. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in head neurons; intestine; and pseudocoelom. Human ortholog(s) of this gene implicated in several diseases, including female reproductive organ cancer (multiple); hereditary hemorrhagic telangiectasia; juvenile polyposis syndrome; juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome; and seminoma. Orthologous to human SMAD4 (SMAD family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
sma-4
M02484_2.00		 Caenorhabditis elegans
NNCCAGACANN
NNTGTCTGGNN		 PBM
Weirauch et al.(2014)
pTH8996		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.700 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M02484_2.00 SMAD 55 155

DNA Binding Domains

Protein ID Domain From To Sequence
R12B2.1a.1 SMAD 163 263
R12B2.1a.2 SMAD 163 263
R12B2.1a.3 SMAD 163 263

Links

Other SMAD family TFs
Other Caenorhabditis elegans TFs

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72 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action