|
ENSBTAP00000029021-D3
(Bos grunniens)
SMAD
|
TF Information |
Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
PF03165 (MH1) |
IPR003619 |
ENSBTAP00000029021-D3 |
T325292_2.00 |
GigaDB (2015-Oct-22) |
NCBI Gene Info:This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016] |
Directly determined binding motifs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
No direct experiments |
|
|
|
|
|
Motifs from related TFs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
SMAD9
M11274_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SMAD8_01
|
1.000
|
1.000
|
Smad9
M11290_2.00 |
Rattus norvegicus |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SMAD8_02
|
1.000
|
1.000
|
Smad9
M11289_2.00 |
Mus musculus |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SMAD8_03
|
1.000
|
1.000
|
SMAD1
M11286_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SMAD1_01
|
0.951
|
0.951
|
SMAD1
M11287_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SMAD1_Q6
|
0.951
|
0.951
|
Smad5
M11288_2.00 |
Mus musculus |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SMAD5_01
|
0.931
|
0.931
|
Smad5
M11292_2.00 |
Rattus norvegicus |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SMAD5_03
|
0.931
|
0.931
|
Mad
M06446_2.00 |
Drosophila melanogaster |
GYGHCGBCVS |
SBGVCGDCRC |
B1H
Zhu et al.(2011)
Mad_FlyReg_FBgn0011648
|
0.912
|
0.912
|
Mad
M08427_2.00 |
Drosophila melanogaster |
SNGRCGMSRVSRBNS |
SNVYSBYSKCGYCNS |
ChIP-chip
Mathelier et al.(2014)
MA0535.1
|
0.912
|
0.912
|
Mad
M09692_2.00 |
Drosophila melanogaster |
KCBGSHGKCGCSNC |
GNSGCGMCDSCVGM |
Misc
Kulakovskiy et al.(2009)
Mad
|
0.912
|
0.912
|
Mad
M11293_2.00 |
Drosophila melanogaster |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
I$MAD_Q6
|
0.912
|
0.912
|
Smad3
M00192_2.00 |
Mus musculus |
NNNNNMGMCN |
NGKCKNNNNN |
PBM
Badis et al.(2009)
Smad3_3805
|
0.716
|
0.716
|
SMAD3
M03482_2.00 |
Homo sapiens |
YGTCTAGACA |
TGTCTAGACR |
SELEX
Jolma et al.(2013)
SMAD3_1
|
0.716
|
0.716
|
SMAD3
M09380_2.00 |
Homo sapiens |
NBCTSHCWSCWB |
VWGSWGDSAGVN |
Misc
Kulakovskiy et al.(2013)
SMAD3_HUMAN.H11MO.0.B
|
0.716
|
0.716
|
Smad3
M09384_2.00 |
Mus musculus |
NBCTSHCWSCWB |
VWGSWGDSAGVN |
Misc
Kulakovskiy et al.(2013)
SMAD3_MOUSE.H11MO.0.B
|
0.716
|
0.716
|
Smad3
M09637_2.00 |
Mus musculus |
BYAGMCWN |
NWGKCTRV |
Misc
Heinz et al.(2010)
NPC-Smad3_GSE36673
|
0.716
|
0.716
|
SMAD3
M11283_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SMAD3_Q6_01
|
0.716
|
0.716
|
SMAD3
M11284_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SMAD3_Q6_02
|
0.716
|
0.716
|
SMAD3
M11285_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SMAD3_Q6
|
0.716
|
0.716
|
For this family, TFs with SR scores > 0.700 will likely have a similar motif |