ENSP00000332973 (Macaca fascicularis)
SMAD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF03165 (MH1) IPR003619 ENSP00000332973 T325295_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Smad3
M00192_2.00
Mus musculus
NNNNNMGMCN

NGKCKNNNNN
PBM
Badis et al.(2009)
Smad3_3805
0.950 0.950
SMAD3
M03482_2.00
Homo sapiens
YGTCTAGACA

TGTCTAGACR
SELEX
Jolma et al.(2013)
SMAD3_1
0.950 0.950
SMAD3
M09380_2.00
Homo sapiens
NBCTSHCWSCWB

VWGSWGDSAGVN
Misc
Kulakovskiy et al.(2013)
SMAD3_HUMAN.H11MO.0.B
0.950 0.950
Smad3
M09384_2.00
Mus musculus
NBCTSHCWSCWB

VWGSWGDSAGVN
Misc
Kulakovskiy et al.(2013)
SMAD3_MOUSE.H11MO.0.B
0.950 0.950
Smad3
M09637_2.00
Mus musculus
BYAGMCWN

NWGKCTRV
Misc
Heinz et al.(2010)
NPC-Smad3_GSE36673
0.950 0.950
SMAD3
M11283_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD3_Q6_01
0.950 0.950
SMAD3
M11284_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD3_Q6_02
0.950 0.950
SMAD3
M11285_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD3_Q6
0.950 0.950
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000332973 SMAD 31 130

Links

Other SMAD family TFs
Other Macaca fascicularis TFs

114 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Gfo_R000026 Geospiza fortis Gfo_R000026 I 1.000
Brh_R001114 Buceros rhinoceros Brh_R001114 I 0.974
ENSGMOG00000001314 Gadus morhua ENSGMOG00000001314 I 0.974
ENSPANG00000016627 Papio anubis ENSPANG00000016627 I 0.960
SMAD3 Macaca mulatta ENSMMUG00000015455 I 0.960
ENSCSAG00000013275 Chlorocebus sabaeus ENSCSAG00000013275 I 0.960
SMAD3 Choloepus hoffmanni ENSCHOG00000001562 I 0.959
SMAD3 Cavia porcellus ENSCPOG00000021314 I 0.950
ENSOARG00000018267 Ovis aries ENSOARG00000018267 I 0.949
Tal_R011237 Tyto alba Tal_R011237 I 0.947
ENSAPLG00000011496 Anas platyrhynchos ENSAPLG00000011496 I 0.947
Tal_R000062 Tyto alba Tal_R000062 I 0.943
Smad3 Mus musculus ENSMUSG00000032402 D 0.941
SMAD3 Microcebus murinus ENSMICG00000006119 I 0.941
SMAD3 Otolemur garnettii ENSOGAG00000014217 I 0.941
ENSNLEG00000012983 Nomascus leucogenys ENSNLEG00000012983 I 0.941
Myotis_brandtii_Smad3_10022298 Myotis brandtii Myotis_brandtii_Smad3_10022298 I 0.941
SMAD3 Pteropus vampyrus ENSPVAG00000002626 I 0.941
Smad3 Rattus norvegicus ENSRNOG00000008620 I 0.941
ENSP00000332973-D1 Bos grunniens ENSP00000332973-D1 I 0.941
SMAD3 Pan troglodytes ENSPTRG00000007199 I 0.941
ENSSTOG00000010286 Ictidomys tridecemlineatus ENSSTOG00000010286 I 0.941
SMAD3 Ochotona princeps ENSOPRG00000014996 I 0.941
ENSPPYG00000006583 Pongo abelii ENSPPYG00000006583 I 0.941
SMAD3 Dasypus novemcinctus ENSDNOG00000044090 I 0.941
SMAD3 Homo sapiens ENSG00000166949 D 0.941
ENSAMEG00000003318 Ailuropoda melanoleuca ENSAMEG00000003318 I 0.941
SMAD3 Callithrix jacchus ENSCJAG00000002088 I 0.941
SMAD3 Canis familiaris ENSCAFG00000017388 I 0.941
SMAD3 Monodelphis domestica ENSMODG00000009609 I 0.940
ENSFALG00000012861 Ficedula albicollis ENSFALG00000012861 I 0.940
Gfo_R005908 Geospiza fortis Gfo_R005908 I 0.940
SMAD3 Procavia capensis ENSPCAG00000008103 I 0.940
ENSGALG00000007870 Gallus gallus ENSGALG00000007870 I 0.930
Afo_R015053 Aptenodytes forsteri Afo_R015053 I 0.930
Aan_R005610 Calypte anna Aan_R005610 I 0.930
SMAD3 Echinops telfairi ENSETEG00000003356 I 0.921
ENSAMXG00000002880 Astyanax mexicanus ENSAMXG00000002880 I 0.910
ENSTBEG00000003884 Tupaia belangeri ENSTBEG00000003884 I 0.910
smad3a Danio rerio ENSDARG00000036096 I 0.910
ENSLOCG00000013897 Lepisosteus oculatus ENSLOCG00000013897 I 0.901
smad3a Takifugu rubripes ENSTRUG00000016858 I 0.900
ENSPFOG00000006336 Poecilia formosa ENSPFOG00000006336 I 0.900
smad3a Tetraodon nigroviridis ENSTNIG00000009546 I 0.900
ENSGALG00000014184 Gallus gallus ENSGALG00000014184 I 0.890
AAB39329 Xenopus laevis AAB39329 I 0.890
Aan_R002236 Calypte anna Aan_R002236 I 0.890
ENSMGAG00000001351 Meleagris gallopavo ENSMGAG00000001351 I 0.890
ENSONIG00000013271 Oreochromis niloticus ENSONIG00000013271 I 0.890
ENSPSIG00000010579 Pelodiscus sinensis ENSPSIG00000010579 I 0.889
Tal_R001210 Tyto alba Tal_R001210 I 0.889
Brh_R001115 Buceros rhinoceros Brh_R001115 I 0.889
ENSAPLG00000007006 Anas platyrhynchos ENSAPLG00000007006 I 0.889
smad3a Oryzias latipes ENSORLG00000002207 I 0.881
ENSXMAG00000002377 Xiphophorus maculatus ENSXMAG00000002377 I 0.881
smad3 Xenopus tropicalis XB-GENE-481992 I 0.881
ENSGMOG00000008364 Gadus morhua ENSGMOG00000008364 I 0.880
smad3b Gasterosteus aculeatus ENSGACG00000005092 I 0.880
smad2.S Xenopus laevis XB-GENE-864923 I 0.880
smad3b Danio rerio ENSDARG00000010207 I 0.871
ENSGACG00000017820 Gasterosteus aculeatus ENSGACG00000017820 I 0.871
smad3.L Xenopus laevis XB-GENE-864816 I 0.871
ENSBTAP00000003668-D4 Bos grunniens ENSBTAP00000003668-D4 I 0.871
ENSORLG00000011834 Oryzias latipes ENSORLG00000011834 I 0.871
Gfo_R012055 Geospiza fortis Gfo_R012055 I 0.871
ENSSTOG00000003788 Ictidomys tridecemlineatus ENSSTOG00000003788 I 0.871
SMAD2 Sorex araneus ENSSARG00000003487 I 0.871
SMAR008230 Strigamia maritima SMAR008230 I 0.870
ENSONIG00000015464 Oreochromis niloticus ENSONIG00000015464 I 0.870
smad3b Oryzias latipes ENSORLG00000006803 I 0.861
ENSONIG00000004109 Oreochromis niloticus ENSONIG00000004109 I 0.861
ENSPMAG00000004234 Petromyzon marinus ENSPMAG00000004234 I 0.857
ENSXMAG00000003553 Xiphophorus maculatus ENSXMAG00000003553 I 0.851
smad3b Tetraodon nigroviridis ENSTNIG00000008432 I 0.851
ENSPFOG00000008802 Poecilia formosa ENSPFOG00000008802 I 0.851
ENSPFOG00000002285 Poecilia formosa ENSPFOG00000002285 I 0.851
ENSPFOG00000004885 Poecilia formosa ENSPFOG00000004885 I 0.851
smad3b Takifugu rubripes ENSTRUG00000014802 I 0.850
ENSXMAG00000004505 Xiphophorus maculatus ENSXMAG00000004505 I 0.850
ENSTNIG00000004827 Tetraodon nigroviridis ENSTNIG00000004827 I 0.842
ACEP23524 Atta cephalotes ACEP23524 I 0.842
L798_14024 Zootermopsis nevadensis L798_14024 I 0.840
SMAD2 Microcebus murinus ENSMICG00000007882 I 0.837
ENSAPLG00000004964 Anas platyrhynchos ENSAPLG00000004964 I 0.828
ENSPMAG00000000489 Petromyzon marinus ENSPMAG00000000489 I 0.822
SMAD3 Meleagris gallopavo ENSMGAG00000009879 I 0.821
SMAD3 Taeniopygia guttata ENSTGUG00000009470 I 0.810
ENSSHAG00000012543 Sarcophilus harrisii ENSSHAG00000012543 I 0.808
SPU_017642 Strongylocentrotus purpuratus SPU_017642 I 0.802
CGI_10017370 Crassostrea gigas CGI_10017370 I 0.800
PPAI005080 Phlebotomus papatasi PPAI005080 I 0.795
ML011743a Mnemiopsis leidyi ML011743a I 0.790
CapteG167863 Capitella teleta CapteG167863 I 0.790
ISCW001846 Ixodes scapularis ISCW001846 I 0.790
NEMVEDRAFT_v1g168041 Nematostella vectensis NEMVEDRAFT_v1g168041 I 0.790
estExt_gwp.C_540260 Branchiostoma floridae estExt_gwp.C_540260 I 0.782
estExt_fgenesh2_pg.C_1720042 Branchiostoma floridae estExt_fgenesh2_pg.C_1720042 I 0.782
DAPPUDRAFT_314805 Daphnia pulex DAPPUDRAFT_314805 I 0.772
SMAD3 Gasterosteus aculeatus ENSGACG00000016882 I 0.767
LotgiG189014 Lottia gigantea LotgiG189014 I 0.762
Alligator_sinensis_CCG004626.1 Alligator sinensis Alligator_sinensis_CCG004626.1 I 0.747
TTRE_0000192701 Trichuris trichiura TTRE_0000192701 I 0.730
D918_09504 Trichuris suis D918_09504 I 0.730
XP_002157279.1 Hydra magnipapillata XP_002157279.1 I 0.725
TMUE_s0005013500 Trichuris muris TMUE_s0005013500 I 0.723
NV10880 Nasonia vitripennis NV10880 I 0.723
PHUM033930 Pediculus humanus PHUM033930 I 0.720
EFV60166 Trichinella spiralis EFV60166 I 0.720
D917_04509 Trichinella nativa D917_04509 I 0.720
ADIR005117 Anopheles dirus ADIR005117 I 0.718
ENSCSAVG00000004749 Ciona savignyi ENSCSAVG00000004749 I 0.710
ENSPMAG00000009833 Petromyzon marinus ENSPMAG00000009833 I 0.710
TriadG49742 Trichoplax adhaerens TriadG49742 I 0.710
HelroG185435 Helobdella robusta HelroG185435 I 0.710