CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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ENSP00000381452
(
Macaca fascicularis
)
SMAD
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
PF03165 (MH1)
IPR003619
ENSP00000381452
T325300_2.00
GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasing blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, May 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Smad4
M05889_2.00
Mus musculus
KCYAGACR
YGTCTRGM
SMiLE-seq
Isakova et al.(2017)
Smad4
1.000
1.000
SMAD4
M09377_2.00
Homo sapiens
DRGTGNSAGACWN
NWGTCTSNCACYH
Misc
Kulakovskiy et al.(2013)
SMAD4_HUMAN.H11MO.0.B
1.000
1.000
Smad4
M09382_2.00
Mus musculus
DGWGNBAGVCWN
NWGBCTVNCWCH
Misc
Kulakovskiy et al.(2013)
SMAD4_MOUSE.H11MO.0.A
1.000
1.000
SMAD4
M09634_2.00
Homo sapiens
NNNYGTCTGS
SCAGACRNNN
Misc
Heinz et al.(2010)
ESC-SMAD4_GSE29422
1.000
1.000
SMAD4
M11275_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD4_Q4
1.000
1.000
SMAD4
M11276_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD4_Q6_01
1.000
1.000
SMAD4
M11277_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD4_Q6
1.000
1.000
Med
M06447_2.00
Drosophila melanogaster
KCGBCDKKSHVT
ABDSMMHGVCGM
B1H
Zhu et al.(2011)
Med_FlyReg_FBgn0011655
0.961
0.961
Med
M09693_2.00
Drosophila melanogaster
YYBYVYCTGYY
RRCAGRBRVRR
Misc
Kulakovskiy et al.(2009)
Med
0.961
0.961
For this family, TFs with SR scores >
0.700
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000381452
SMAD
36
137
AKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVV
Links
Other
SMAD
family TFs
Other
Macaca fascicularis
TFs
217 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
SMAD4
Equus caballus
ENSECAG00000017857
I
1.000
Smad4
Dipodomys ordii
ENSDORG00000009089
I
1.000
SMAD4
Echinops telfairi
ENSETEG00000007750
I
1.000
SMAD4
Felis catus
ENSFCAG00000005257
I
1.000
ENSPPYG00000009165
Pongo abelii
ENSPPYG00000009165
I
1.000
SMAD4
Homo sapiens
ENSG00000141646
D
1.000
SMAD4
Dasypus novemcinctus
ENSDNOG00000005063
I
1.000
Afo_R008709
Aptenodytes forsteri
Afo_R008709
I
1.000
SMAD4
Cavia porcellus
ENSCPOG00000006470
I
1.000
SMAD4
Callithrix jacchus
ENSCJAG00000001910
I
1.000
SMAD4
Otolemur garnettii
ENSOGAG00000012081
I
1.000
Brh_R010414
Buceros rhinoceros
Brh_R010414
I
1.000
Alligator_sinensis_CCG008910.1
Alligator sinensis
Alligator_sinensis_CCG008910.1
I
1.000
ENSPSIG00000014614
Pelodiscus sinensis
ENSPSIG00000014614
I
1.000
ENSPANG00000024703
Papio anubis
ENSPANG00000024703
I
1.000
SMAD4
Gorilla gorilla
ENSGGOG00000013662
I
1.000
ENSNLEG00000011859
Nomascus leucogenys
ENSNLEG00000011859
I
1.000
Smad4
Mus musculus
ENSMUSG00000024515
D
1.000
SMAD4
Ornithorhynchus anatinus
ENSOANG00000008117
I
1.000
ENSOANG00000030959
Ornithorhynchus anatinus
ENSOANG00000030959
I
1.000
SMAD4
Oryctolagus cuniculus
ENSOCUG00000003929
I
1.000
ENSOARG00000004662
Ovis aries
ENSOARG00000004662
I
1.000
ENSMPUG00000008776
Mustela putorius furo
ENSMPUG00000008776
I
1.000
SMAD4
Monodelphis domestica
ENSMODG00000010995
I
1.000
SMAD4
Loxodonta africana
ENSLAFG00000012595
I
1.000
SMAD4
Ochotona princeps
ENSOPRG00000013601
I
1.000
SMAD4
Microcebus murinus
ENSMICG00000017525
I
1.000
SMAD4
Myotis lucifugus
ENSMLUG00000013944
I
1.000
SMAD4
Macaca mulatta
ENSMMUG00000018334
I
1.000
SMAD4
Pan troglodytes
ENSPTRG00000010028
I
1.000
ENSCSAG00000018094
Chlorocebus sabaeus
ENSCSAG00000018094
I
1.000
ENSSHAG00000010344
Sarcophilus harrisii
ENSSHAG00000010344
I
1.000
AAH84196
Xenopus laevis
AAH84196
I
1.000
SMAD4
Choloepus hoffmanni
ENSCHOG00000000860
I
1.000
Ogr14199
Ophisaurus gracilis
Ogr14199
I
1.000
Smad4
Rattus norvegicus
ENSRNOG00000051965
I
1.000
SMAD4
Sus scrofa
ENSSSCG00000004524
I
1.000
ENSSTOG00000028580
Ictidomys tridecemlineatus
ENSSTOG00000028580
I
1.000
ENSTSYG00000009792
Tarsius syrichta
ENSTSYG00000009792
I
1.000
SMAD4
Vicugna pacos
ENSVPAG00000006757
I
1.000
smad4.1.L
Xenopus laevis
XB-GENE-865543
I
1.000
smad4.1
Xenopus tropicalis
XB-GENE-485691
I
1.000
SMAD4
Tupaia belangeri
ENSTBEG00000014105
I
1.000
Myotis_brandtii_Smad4_10005924
Myotis brandtii
Myotis_brandtii_Smad4_10005924
I
1.000
Pvit_01119
Pogona vitticeps
Pvit_01119
I
1.000
SMAD4
Pteropus vampyrus
ENSPVAG00000004261
I
1.000
SMAD4
Canis familiaris
ENSCAFG00000000164
I
1.000
ENSP00000341551-D1
Bos grunniens
ENSP00000341551-D1
I
1.000
Cmyd_10005540
Chelonia mydas
Cmyd_10005540
I
1.000
SMAD4
Bos taurus
ENSBTAG00000006919
I
1.000
ENSAPLG00000003924
Anas platyrhynchos
ENSAPLG00000003924
I
1.000
SMAD4
Anolis carolinensis
ENSACAG00000010186
I
1.000
ENSAMEG00000002899
Ailuropoda melanoleuca
ENSAMEG00000002899
I
1.000
Gfo_R016223
Geospiza fortis
Gfo_R016223
I
1.000
Gfo_R011803
Geospiza fortis
Gfo_R011803
I
1.000
SMAD4
Tetraodon nigroviridis
ENSTNIG00000009050
I
0.990
SMAD4
Takifugu rubripes
ENSTRUG00000014045
I
0.990
ENSPFOG00000018987
Poecilia formosa
ENSPFOG00000018987
I
0.990
ENSPFOG00000019807
Poecilia formosa
ENSPFOG00000019807
I
0.990
ENSAMXG00000019219
Astyanax mexicanus
ENSAMXG00000019219
I
0.990
smad4a
Oryzias latipes
ENSORLG00000005020
I
0.990
SMAD4
Oryzias latipes
ENSORLG00000007703
I
0.990
smad4a
Danio rerio
ENSDARG00000075226
I
0.990
ENSXMAG00000015245
Xiphophorus maculatus
ENSXMAG00000015245
I
0.990
ENSXMAG00000005051
Xiphophorus maculatus
ENSXMAG00000005051
I
0.990
ISCW018468
Ixodes scapularis
ISCW018468
I
0.980
ENSONIG00000015035
Oreochromis niloticus
ENSONIG00000015035
I
0.980
ENSONIG00000014036
Oreochromis niloticus
ENSONIG00000014036
I
0.980
ENSGMOG00000005844
Gadus morhua
ENSGMOG00000005844
I
0.980
PPAI002168
Phlebotomus papatasi
PPAI002168
I
0.980
ENSGACG00000016858
Gasterosteus aculeatus
ENSGACG00000016858
I
0.980
smad4a
Gasterosteus aculeatus
ENSGACG00000007495
I
0.980
e_gw.452.68.1
Branchiostoma floridae
e_gw.452.68.1
I
0.980
LLOJ008806
Lutzomyia longipalpis
LLOJ008806
I
0.980
SMAD4
Danio rerio
ENSDARG00000012649
I
0.971
Ogr06720
Ophisaurus gracilis
Ogr06720
I
0.971
L798_13939
Zootermopsis nevadensis
L798_13939
I
0.971
SMAR013850
Strigamia maritima
SMAR013850
I
0.971
AAEL013896
Aedes aegypti
AAEL013896
I
0.971
ENSMEUG00000001823
Macropus eugenii
ENSMEUG00000001823
I
0.971
PHUM002670
Pediculus humanus
PHUM002670
I
0.971
ENSGMOG00000013964
Gadus morhua
ENSGMOG00000013964
I
0.971
GL23637
Drosophila persimilis
FBgn0161227
I
0.961
CpipJ_CPIJ002563
Culex pipiens
CpipJ_CPIJ002563
I
0.961
smad4.2.S
Xenopus laevis
XB-GENE-5995204
I
0.961
GG11819
Drosophila erecta
FBgn0104114
I
0.961
GI23400
Drosophila mojavensis
FBgn0146126
I
0.961
MDOA012885
Musca domestica
MDOA012885
I
0.961
GH18642
Drosophila grimshawi
FBgn0126109
I
0.961
smad4.2.L
Xenopus laevis
XB-GENE-6256010
I
0.961
GJ23092
Drosophila virilis
FBgn0210194
I
0.961
Hsal_09633--XP_392838.3_APIME
Harpegnathos saltator
Hsal_09633--XP_392838.3_APIME
I
0.961
GB50071
Apis mellifera
GB50071
I
0.961
SINV15516
Solenopsis invicta
SINV15516
I
0.961
GF22974
Drosophila ananassae
FBgn0099968
I
0.961
NV12984
Nasonia vitripennis
NV12984
I
0.961
GE10952
Drosophila yakuba
FBgn0228782
I
0.961
GK11724
Drosophila willistoni
FBgn0213735
I
0.961
LCUP007928
Lucilia cuprina
LCUP007928
I
0.961
HHAL000393-PA
Halyomorpha halys
HHAL000393-PA
I
0.961
Cflo_07183--XP_392838.3_APIME
Camponotus floridanus
Cflo_07183--XP_392838.3_APIME
I
0.961
TC010848
Tribolium castaneum
TC010848
I
0.961
LDEC015949
Leptinotarsa decemlineata
LDEC015949
I
0.961
GM16436
Drosophila sechellia
FBgn0171351
I
0.961
ENSAMXG00000017275
Astyanax mexicanus
ENSAMXG00000017275
I
0.961
CPIJ002563
Culex quinquefasciatus
CPIJ002563
I
0.961
GA14643
Drosophila pseudoobscura
FBgn0074670
I
0.961
ENSONIG00000010360
Oreochromis niloticus
ENSONIG00000010360
I
0.961
ENSLACG00000007810
Latimeria chalumnae
ENSLACG00000007810
I
0.961
ENSAMXG00000018339
Astyanax mexicanus
ENSAMXG00000018339
I
0.961
Med
Drosophila melanogaster
FBgn0011655
D
0.961
si:dkey-222b8.1
Gasterosteus aculeatus
ENSGACG00000000538
I
0.961
si:dkey-222b8.1
Takifugu rubripes
ENSTRUG00000004163
I
0.961
si:dkey-222b8.1
Danio rerio
ENSDARG00000045094
I
0.961
AARA004719
Anopheles arabiensis
AARA004719
I
0.951
HHAL000394-PA
Halyomorpha halys
HHAL000394-PA
I
0.951
AGAP002902
Anopheles gambiae
AGAP002902
I
0.951
DAPPUDRAFT_304115
Daphnia pulex
DAPPUDRAFT_304115
I
0.951
si:dkey-239n17.4
Danio rerio
ENSDARG00000070428
I
0.951
AATE010695
Anopheles atroparvus
AATE010695
I
0.951
BGIBMGA010110
Bombyx mori
BGIBMGA010110
I
0.951
ACUA025512
Anopheles culicifacies
ACUA025512
I
0.951
AMIN000723
Anopheles minimus
AMIN000723
I
0.951
AMEM015931
Anopheles merus
AMEM015931
I
0.951
AQUA009305
Anopheles quadriannulatus
AQUA009305
I
0.951
ASTEI00079
Anopheles stephensi
ASTEI00079
I
0.951
ACYPI000365
Acyrthosiphon pisum
ACYPI000365
I
0.951
BGLB014287
Biomphalaria glabrata
BGLB014287
I
0.951
AMAM019778
Anopheles maculatus
AMAM019778
I
0.951
AFUN009864
Anopheles funestus
AFUN009864
I
0.951
YQE_06624
Dendroctonus ponderosae
YQE_06624
I
0.951
ACOM037505
Anopheles coluzzii
ACOM037505
I
0.951
ADIR002761
Anopheles dirus
ADIR002761
I
0.951
AEPI002385
Anopheles epiroticus
AEPI002385
I
0.951
AFAF011208
Anopheles farauti
AFAF011208
I
0.951
ACHR000067
Anopheles christyi
ACHR000067
I
0.951
CLEC002594
Cimex lectularius
CLEC002594
I
0.951
KGM_12572
Danaus plexippus
KGM_12572
I
0.951
MCINX014520
Melitaea cinxia
MCINX014520
I
0.951
RPRC010188
Rhodnius prolixus
RPRC010188
I
0.951
ENSGMOG00000000297
Gadus morhua
ENSGMOG00000000297
I
0.951
HMEL002203
Heliconius melpomene
HMEL002203
I
0.951
ENSPMAG00000008404
Petromyzon marinus
ENSPMAG00000008404
I
0.951
gb:cr929477
Takifugu rubripes
ENSTRUG00000011769
I
0.951
gb:cr929477
Tetraodon nigroviridis
ENSTNIG00000003193
I
0.951
Ocbimv22032358m.g
Octopus bimaculoides
Ocbimv22032358m.g
I
0.941
ENSONIG00000001557
Oreochromis niloticus
ENSONIG00000001557
I
0.941
ENSPMAG00000009414
Petromyzon marinus
ENSPMAG00000009414
I
0.941
LotgiG131078
Lottia gigantea
LotgiG131078
I
0.941
SPU_004287
Strongylocentrotus purpuratus
SPU_004287
I
0.941
CapteG179368
Capitella teleta
CapteG179368
I
0.931
NEMVEDRAFT_v1g248037
Nematostella vectensis
NEMVEDRAFT_v1g248037
I
0.931
AALB009485
Anopheles albimanus
AALB009485
I
0.931
ADAC007516
Anopheles darlingi
ADAC007516
I
0.931
smad4
Ciona intestinalis
ENSCING00000005559
I
0.922
ENSCSAVG00000006480
Ciona savignyi
ENSCSAVG00000006480
I
0.922
fgenesh2_pg.scaffold_230000050
Branchiostoma floridae
fgenesh2_pg.scaffold_230000050
I
0.912
tetur10g00400
Tetranychus urticae
tetur10g00400
I
0.912
CGI_10018464
Crassostrea gigas
CGI_10018464
I
0.911
ENSGACG00000003171
Gasterosteus aculeatus
ENSGACG00000003171
I
0.902
ACYPI003759
Acyrthosiphon pisum
ACYPI003759
I
0.902
si:dkey-222b8.1
Tetraodon nigroviridis
ENSTNIG00000005007
I
0.902
ENSPFOG00000019867
Poecilia formosa
ENSPFOG00000019867
I
0.902
YQE_08737
Dendroctonus ponderosae
YQE_08737
I
0.892
ACYPI008450
Acyrthosiphon pisum
ACYPI008450
I
0.892
HelroG88197
Helobdella robusta
HelroG88197
I
0.882
XP_002161797.1
Hydra magnipapillata
XP_002161797.1
I
0.882
Alligator_sinensis_CCG001823.1
Alligator sinensis
Alligator_sinensis_CCG001823.1
I
0.882
ACYPI005550
Acyrthosiphon pisum
ACYPI005550
I
0.873
SPU_017971
Strongylocentrotus purpuratus
SPU_017971
I
0.873
ML02191a
Mnemiopsis leidyi
ML02191a
I
0.863
Aqu1.215834
Amphimedon queenslandica
Aqu1.215834
I
0.863
Aqu1.215833
Amphimedon queenslandica
Aqu1.215833
I
0.863
Aan_R014474
Calypte anna
Aan_R014474
I
0.845
ACEP19585
Atta cephalotes
ACEP19585
I
0.843
TTRE_0000855901
Trichuris trichiura
TTRE_0000855901
I
0.833
TMUE_s0006012700
Trichuris muris
TMUE_s0006012700
I
0.833
EFV62078
Trichinella spiralis
EFV62078
I
0.824
D917_09719
Trichinella nativa
D917_09719
I
0.824
CGI_10000594
Crassostrea gigas
CGI_10000594
I
0.821
SMU15015494
Schmidtea mediterranea
SMU15015494
I
0.814
D915_03789
Fasciola hepatica
D915_03789
I
0.804
TriadG30731
Trichoplax adhaerens
TriadG30731
I
0.804
ASIM_0001604001
Anisakis simplex
ASIM_0001604001
I
0.804
T265_11013
Opisthorchis viverrini
T265_11013
I
0.804
GPUH_0001329001
Gongylonema pulchrum
GPUH_0001329001
I
0.794
ECPE_0001832001
Echinostoma caproni
ECPE_0001832001
I
0.794
BTMF_0000404601
Brugia timori
BTMF_0000404601
I
0.784
HelroG76435
Helobdella robusta
HelroG76435
I
0.784
Bm3575
Brugia malayi
Bm3575
I
0.784
ENSLOCG00000012872
Lepisosteus oculatus
ENSLOCG00000012872
I
0.784
nLs.2.1.2.g01457
Litomosoides sigmodontis
nLs.2.1.2.g01457
I
0.775
EEL_0000707501
Elaeophora elaphi
EEL_0000707501
I
0.775
nAv.1.0.1.g00430
Acanthocheilonema viteae
nAv.1.0.1.g00430
I
0.775
nDi.2.2.2.g01429
Dirofilaria immitis
nDi.2.2.2.g01429
I
0.775
WUBG_02880
Wuchereria bancrofti
WUBG_02880
I
0.775
ASU_13433
Ascaris suum
ASU_13433
I
0.775
TRE_0001987301
Trichobilharzia regenti
TRE_0001987301
I
0.775
tetur10g00380
Tetranychus urticae
tetur10g00380
I
0.767
nOo.2.0.1.g00181
Onchocerca ochengi
nOo.2.0.1.g00181
I
0.765
NEMVEDRAFT_v1g18576
Nematostella vectensis
NEMVEDRAFT_v1g18576
I
0.765
WBGene00241622
Onchocerca volvulus
WBGene00241622
I
0.765
TCLT_0000917301
Thelazia callipaeda
TCLT_0000917301
I
0.765
LOAG_08923
Loa loa
LOAG_08923
I
0.765
D918_00298
Trichuris suis
D918_00298
I
0.760
Sjc_0030450
Schistosoma japonicum
Sjc_0030450
I
0.755
Sakowv30001112m.g
Saccoglossus kowalevskii
Sakowv30001112m.g
I
0.746
Aqu1.229767
Amphimedon queenslandica
Aqu1.229767
I
0.745
Smp_033950
Schistosoma mansoni
Smp_033950
I
0.725
SMTD_0002197901
Schistosoma mattheei
SMTD_0002197901
I
0.725
SROB_0000384401
Schistosoma rodhaini
SROB_0000384401
I
0.716
ANCCAN_20978
Ancylostoma caninum
ANCCAN_20978
I
0.706
GPLIN_000772200
Globodera pallida
GPLIN_000772200
I
0.706
OESDEN_03018
Oesophagostomum dentatum
OESDEN_03018
I
0.706
SVUK_0000938201
Strongylus vulgaris
SVUK_0000938201
I
0.706
TELCIR_19676
Teladorsagia circumcincta
TELCIR_19676
I
0.706
HPBE_0001599301
Heligmosomoides bakeri
HPBE_0001599301
I
0.702