|
|
HHAL000394-PA
(Halyomorpha halys)
SMAD
|
TF Information |
|---|
| Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
| PF03165 (MH1) |
IPR003619 |
HHAL000394-PA |
T325394_2.00 |
Misc (2018-Jan-19) |
| NCBI Gene Info:This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016] |
Directly determined binding motifs |
|---|
| Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR
Score |
DBD
Identity |
| No direct experiments |
|
|
|
|
|
Motifs from related TFs |
|---|
| Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR
Score |
DBD
Identity |
Med
M06447_2.00 |
Drosophila melanogaster |
KCGBCDKKSHVT |
ABDSMMHGVCGM |
B1H
Zhu et al.(2011)
Med_FlyReg_FBgn0011655
|
0.971
|
0.971
|
Med
M09693_2.00 |
Drosophila melanogaster |
YYBYVYCTGYY |
RRCAGRBRVRR |
Misc
Kulakovskiy et al.(2009)
Med
|
0.971
|
0.971
|
Smad4
M05889_2.00 |
Mus musculus |
KCYAGACR |
YGTCTRGM |
SMiLE-seq
Isakova et al.(2017)
Smad4
|
0.951
|
0.951
|
SMAD4
M09377_2.00 |
Homo sapiens |
DRGTGNSAGACWN |
NWGTCTSNCACYH |
Misc
Kulakovskiy et al.(2013)
SMAD4_HUMAN.H11MO.0.B
|
0.951
|
0.951
|
Smad4
M09382_2.00 |
Mus musculus |
DGWGNBAGVCWN |
NWGBCTVNCWCH |
Misc
Kulakovskiy et al.(2013)
SMAD4_MOUSE.H11MO.0.A
|
0.951
|
0.951
|
SMAD4
M09634_2.00 |
Homo sapiens |
NNNYGTCTGS |
SCAGACRNNN |
Misc
Heinz et al.(2010)
ESC-SMAD4_GSE29422
|
0.951
|
0.951
|
SMAD4
M11275_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SMAD4_Q4
|
0.951
|
0.951
|
SMAD4
M11276_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SMAD4_Q6_01
|
0.951
|
0.951
|
SMAD4
M11277_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SMAD4_Q6
|
0.951
|
0.951
|
| For this family, TFs with SR scores > 0.700 will likely have a similar motif |